SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d8m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JHQ_A_NIOA991_1 (NICOTINATE MONONUCLEOTIDE:5,6-D IMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSF ERASE)	2d8m	DNA-REPAIR PROTEIN XRCC1 (Homo sapiens)	5 / 8	GLY A 81 GLY A 110 LEU A 105 SER A 112 GLY A 108	None	1.43A	1jhqA-2d8mA: undetectable	1jhqA-2d8mA: 18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JHV_A_NIOA991_1 (NICOTINATE MONONUCLEOTIDE:5,6-D IMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSF ERASE)	2d8m	DNA-REPAIR PROTEIN XRCC1 (Homo sapiens)	5 / 8	GLY A 81 GLY A 110 LEU A 105 SER A 112 GLY A 108	None	1.50A	1jhvA-2d8mA: undetectable	1jhvA-2d8mA: 18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XCT_G_CPFG1020_1 (DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A)	2d8m	DNA-REPAIR PROTEIN XRCC1 (Homo sapiens)	3 / 3	ARG A 82 GLY A 81 SER A 31	None	0.55A	2xctB-2d8mA: undetectable	2xctB-2d8mA: 10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UCB_B_017B202_1 (PROTEASE)	2d8m	DNA-REPAIR PROTEIN XRCC1 (Homo sapiens)	4 / 7	PRO A 9 ARG A 11 GLY A 15 PRO A 16	None	1.08A	3ucbB-2d8mA: undetectable	3ucbB-2d8mA: 20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6D8F_A_ACTA803_0 (UNCHARACTERIZED PROTEIN)	2d8m	DNA-REPAIR PROTEIN XRCC1 (Homo sapiens)	3 / 3	GLU A 87 LEU A 90 ARG A 94	None	0.82A	6d8fA-2d8mA: 2.6	6d8fA-2d8mA: 10.28

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1JHQ_A_NIOA991_1","NICOTINATE MONONUCLEOTIDE:5,6-DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE","2d8m","DNA-REPAIR PROTEIN XRCC1","Homo sapiens",5,"GLY A  81;GLY A 110;LEU A 105;SER A 112;GLY A 108","None","1.43A","1jhqA-2d8mA:undetectable","1jhqA-2d8mA:18.81"],["1JHV_A_NIOA991_1","NICOTINATE MONONUCLEOTIDE:5,6-DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE","2d8m","DNA-REPAIR PROTEIN XRCC1","Homo sapiens",5,"GLY A  81;GLY A 110;LEU A 105;SER A 112;GLY A 108","None","1.50A","1jhvA-2d8mA:undetectable","1jhvA-2d8mA:18.81"],["2XCT_G_CPFG1020_1","DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A","2d8m","DNA-REPAIR PROTEIN XRCC1","Homo sapiens",3,"ARG A  82;GLY A  81;SER A  31","None","0.55A","2xctB-2d8mA:undetectable","2xctB-2d8mA:10.51"],["3UCB_B_017B202_1","PROTEASE","2d8m","DNA-REPAIR PROTEIN XRCC1","Homo sapiens",4,"PRO A   9;ARG A  11;GLY A  15;PRO A  16","None","1.08A","3ucbB-2d8mA:undetectable","3ucbB-2d8mA:20.16"],["6D8F_A_ACTA803_0","UNCHARACTERIZED PROTEIN","2d8m","DNA-REPAIR PROTEIN XRCC1","Homo sapiens",3,"GLU A  87;LEU A  90;ARG A  94","None","0.82A","6d8fA-2d8mA:2.6","6d8fA-2d8mA:10.28"]]