SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2d93'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2d93 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6
(Homo
sapiens) 		3 / 3 GLU A  45
GLU A  42
LEU A  65
 None
 0.70A 1v8bA-2d93A:
undetectable		 1v8bA-2d93A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2d93 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6
(Homo
sapiens) 		3 / 3 GLU A  45
GLU A  42
LEU A  65
 None
 0.78A 1v8bB-2d93A:
undetectable		 1v8bB-2d93A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2d93 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6
(Homo
sapiens) 		3 / 3 GLN A 116
THR A  92
THR A  90
 None
 0.80A 4fu9A-2d93A:
undetectable		 4fu9A-2d93A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2d93 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6
(Homo
sapiens) 		3 / 3 GLN A 116
THR A  92
THR A  90
 None
 0.82A 4fufA-2d93A:
undetectable		 4fufA-2d93A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 2d93 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6
(Homo
sapiens) 		5 / 12 ALA A  47
GLY A  48
ASN A  80
GLU A  70
GLU A  79
 None
 0.96A 5nwuA-2d93A:
undetectable		 5nwuA-2d93A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2d93 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6
(Homo
sapiens) 		4 / 6 ILE A  11
LEU A  14
MET A  29
THR A  28
 None
 0.99A 6nmfN-2d93A:
undetectable
6nmfW-2d93A:
undetectable		 6nmfN-2d93A:
13.11
6nmfW-2d93A:
18.92