SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dad'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 2dad ABSENT IN MELANOMA 1
PROTEIN
(Homo
sapiens) 		5 / 10 TYR A  67
VAL A  42
GLY A  65
VAL A  48
GLN A  59
 None
 1.06A 3km6A-2dadA:
undetectable		 3km6A-2dadA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 2dad ABSENT IN MELANOMA 1
PROTEIN
(Homo
sapiens) 		5 / 9 TYR A  67
VAL A  42
GLY A  65
VAL A  48
GLN A  59
 None
 1.07A 3kmoA-2dadA:
undetectable		 3kmoA-2dadA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2dad ABSENT IN MELANOMA 1
PROTEIN
(Homo
sapiens) 		4 / 6 GLN A  18
PHE A  17
LEU A  11
PHE A  81
 None
 1.09A 5z86P-2dadA:
undetectable
5z86W-2dadA:
undetectable		 5z86P-2dadA:
16.60
5z86W-2dadA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2dad ABSENT IN MELANOMA 1
PROTEIN
(Homo
sapiens) 		4 / 6 GLN A  18
PHE A  17
LEU A  11
PHE A  81
 None
 1.09A 5zcoP-2dadA:
undetectable
5zcoW-2dadA:
undetectable		 5zcoP-2dadA:
16.60
5zcoW-2dadA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2dad ABSENT IN MELANOMA 1
PROTEIN
(Homo
sapiens) 		4 / 6 GLN A  18
PHE A  17
LEU A  11
PHE A  81
 None
 1.07A 5zcpP-2dadA:
undetectable
5zcpW-2dadA:
undetectable		 5zcpP-2dadA:
16.60
5zcpW-2dadA:
18.75