SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dao'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 2dao TRANSCRIPTION FACTOR
ETV6
(Homo
sapiens) 		5 / 12 ILE A  77
LEU A  86
HIS A  70
TYR A  61
ILE A  40
 None
 1.17A 1fmlB-2daoA:
undetectable		 1fmlB-2daoA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2dao TRANSCRIPTION FACTOR
ETV6
(Homo
sapiens) 		3 / 3 SER A  20
ASP A  13
CYH A   8
 None
 1.08A 2br4E-2daoA:
undetectable		 2br4E-2daoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 2dao TRANSCRIPTION FACTOR
ETV6
(Homo
sapiens) 		3 / 3 MET A  97
MET A  90
TYR A  16
 None
 1.32A 4p6xI-2daoA:
undetectable		 4p6xI-2daoA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 2dao TRANSCRIPTION FACTOR
ETV6
(Homo
sapiens) 		3 / 3 ARG A  69
GLU A 111
TYR A  72
 None
 0.94A 4r29D-2daoA:
undetectable		 4r29D-2daoA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2dao TRANSCRIPTION FACTOR
ETV6
(Homo
sapiens) 		4 / 7 ILE A  40
LEU A  46
ARG A  69
LEU A  11
 None
 0.85A 5xdqA-2daoA:
undetectable
5xdqJ-2daoA:
undetectable		 5xdqA-2daoA:
11.27
5xdqJ-2daoA:
18.64