SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2db0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 2db0 253AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 LEU A  74
MET A  70
LEU A  41
GLU A  89
 None
 0.80A 2kuhA-2db0A:
undetectable		 2kuhA-2db0A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 2db0 253AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 ILE A  59
ILE A  56
ALA A  93
LEU A  24
ALA A  27
 None
 1.11A 3ozvB-2db0A:
undetectable		 3ozvB-2db0A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2db0 253AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A  60
ALA A  52
ILE A  90
LEU A  74
MET A  70
 None
 1.18A 4r3aA-2db0A:
undetectable		 4r3aA-2db0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2db0 253AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A 183
ILE A 186
LEU A 162
LEU A 190
ALA A 199
 None
 1.16A 5j7wC-2db0A:
undetectable		 5j7wC-2db0A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 2db0 253AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 ILE A  55
ALA A  27
ILE A  59
ILE A  38
LEU A  66
 None
 1.13A 5mvmA-2db0A:
1.9
5mvmE-2db0A:
1.9		 5mvmA-2db0A:
16.14
5mvmE-2db0A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2db0 253AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A  33
GLU A  31
LEU A  24
ALA A  27
ARG A  63
 None
 1.15A 5nd3B-2db0A:
undetectable		 5nd3B-2db0A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 2db0 253AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A 183
ILE A 186
LEU A 162
LEU A 190
ALA A 199
 None
 1.18A 6qxsD-2db0A:
undetectable		 6qxsD-2db0A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 2db0 253AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A 183
ILE A 186
LEU A 162
LEU A 190
ALA A 199
 None
 1.17A 6qyaB-2db0A:
undetectable		 6qyaB-2db0A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 2db0 253AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A 183
ILE A 186
LEU A 162
LEU A 190
ALA A 199
 None
 1.17A 6qyaD-2db0A:
undetectable		 6qyaD-2db0A:
23.80