SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2db3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 12 ILE A 455
LEU A 285
PHE A 431
ILE A 276
PRO A 302
 None
 1.01A 1drfA-2db3A:
undetectable		 1drfA-2db3A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		4 / 6 THR A 615
LEU A 609
GLY A 613
LYS A 466
 None
 1.21A 1gtiC-2db3A:
undetectable		 1gtiC-2db3A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 11 LEU A 308
ALA A 338
ALA A 342
GLN A 320
ARG A 394
 None
 1.42A 1iiuA-2db3A:
undetectable		 1iiuA-2db3A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 8 ALA A 374
ILE A 388
ILE A 365
GLY A 350
ILE A 349
 None
 1.26A 1sh9A-2db3A:
undetectable		 1sh9A-2db3A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		3 / 3 SER A 293
GLU A 400
ASP A 571
 ANP  A2901 (-3.8A)
ANP  A2901 (-4.3A)
None
 0.89A 2avdB-2db3A:
4.2		 2avdB-2db3A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		3 / 3 ASP A 254
VAL A 260
PRO A 268
 None
 0.50A 2avvA-2db3A:
undetectable		 2avvA-2db3A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 9 VAL A 574
GLY A 459
ASP A 402
ASP A 571
GLU A 400
 None
None
None
None
ANP  A2901 (-4.3A)
 1.20A 2j2pB-2db3A:
undetectable
2j2pC-2db3A:
undetectable		 2j2pB-2db3A:
17.93
2j2pC-2db3A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		4 / 6 LEU A 300
ILE A 373
VAL A 371
ALA A 338
 None
 0.86A 2j5mA-2db3A:
undetectable		 2j5mA-2db3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 11 LEU A 347
VAL A 371
LEU A 429
ILE A 256
ILE A 323
 None
 1.13A 2uxoB-2db3A:
undetectable		 2uxoB-2db3A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 12 ILE A 455
LEU A 285
PHE A 431
ILE A 276
PRO A 302
 None
 1.07A 2w3bA-2db3A:
undetectable		 2w3bA-2db3A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 12 ILE A 455
LEU A 285
PHE A 431
ILE A 276
PRO A 302
 None
 1.02A 2w3bB-2db3A:
undetectable		 2w3bB-2db3A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 12 ILE A 455
LEU A 285
PHE A 431
ILE A 276
PRO A 302
 None
 0.99A 2w3mA-2db3A:
undetectable		 2w3mA-2db3A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 12 ILE A 544
VAL A 542
ILE A 493
ILE A 555
VAL A 496
 None
 1.20A 3fpjB-2db3A:
3.1		 3fpjB-2db3A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 12 ILE A 544
VAL A 542
ILE A 555
VAL A 496
ARG A 523
 None
 1.07A 3fpjB-2db3A:
3.1		 3fpjB-2db3A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		4 / 8 GLY A 377
LEU A 379
LEU A 380
ILE A 416
 U  E   6 ( 3.2A)
None
None
None
 0.89A 3nbqB-2db3A:
undetectable		 3nbqB-2db3A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		4 / 8 GLY A 377
LEU A 379
LEU A 380
ILE A 416
 U  E   6 ( 3.2A)
None
None
None
 0.89A 3nbqC-2db3A:
undetectable		 3nbqC-2db3A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		3 / 3 PHE A 343
LYS A 262
SER A 263
 None
 1.05A 3tyeB-2db3A:
undetectable		 3tyeB-2db3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 12 ILE A 455
LEU A 285
PHE A 431
ILE A 276
PRO A 302
 None
 0.94A 4kfjB-2db3A:
undetectable		 4kfjB-2db3A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 10 SER A 550
ILE A 558
VAL A 561
ALA A 545
ILE A 493
 None
 0.97A 4lbgA-2db3A:
2.2		 4lbgA-2db3A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 8 ALA A 461
VAL A 465
GLY A 292
VAL A 561
ILE A 577
 None
None
ANP  A2901 (-3.7A)
None
None
 1.37A 4ll3A-2db3A:
undetectable		 4ll3A-2db3A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 12 ILE A 455
LEU A 285
PHE A 431
ILE A 276
PRO A 302
 None
 0.99A 4m6kA-2db3A:
undetectable		 4m6kA-2db3A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		3 / 3 PRO A 567
MET A 566
TYR A 573
 None
 0.58A 4qa0B-2db3A:
5.2		 4qa0B-2db3A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		3 / 3 PRO A 567
MET A 566
TYR A 573
 None
 0.56A 4qa0A-2db3A:
undetectable		 4qa0A-2db3A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		3 / 3 PRO A 567
MET A 566
TYR A 573
 None
 0.69A 4qa2B-2db3A:
6.5		 4qa2B-2db3A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 11 ILE A 577
SER A 568
ILE A 601
LEU A 605
THR A 291
 None
None
None
None
ANP  A2901 (-4.0A)
 1.26A 4qi9C-2db3A:
undetectable		 4qi9C-2db3A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		3 / 3 GLU A 337
ALA A 338
PHE A 341
 ANP  A2901 ( 4.6A)
None
None
 0.35A 4v1fA-2db3A:
undetectable		 4v1fA-2db3A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		3 / 3 GLU A 337
ALA A 338
PHE A 341
 ANP  A2901 ( 4.6A)
None
None
 0.40A 4v1fC-2db3A:
undetectable		 4v1fC-2db3A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 12 ASP A 399
ASP A 572
HIS A 575
ALA A 433
THR A 580
 MG  A2801 (-3.4A)
None
None
ANP  A2901 ( 3.7A)
None
 1.36A 5hnzB-2db3A:
undetectable		 5hnzB-2db3A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 11 ASP A 464
PHE A 225
ILE A 219
ILE A 455
ILE A 231
 None
ANP  A2901 (-4.6A)
ANP  A2901 (-4.4A)
None
None
 1.03A 5hw8A-2db3A:
undetectable
5hw8D-2db3A:
undetectable		 5hw8A-2db3A:
13.41
5hw8D-2db3A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		3 / 3 ARG A 582
HIS A 575
ARG A 579
 ANP  A2901 (-3.2A)
None
ANP  A2901 (-2.6A)
 1.14A 5iaoC-2db3A:
3.2		 5iaoC-2db3A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		4 / 7 HIS A 560
ILE A 493
VAL A 494
ARG A 576
 None
 1.27A 5kkzK-2db3A:
undetectable
5kkzQ-2db3A:
undetectable		 5kkzK-2db3A:
20.70
5kkzQ-2db3A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		3 / 3 THR A 468
THR A 492
LEU A 481
 None
 0.71A 5m66D-2db3A:
undetectable		 5m66D-2db3A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 10 TYR A 202
PRO A 204
ILE A 332
ILE A 351
THR A 356
 None
 1.17A 5mvnD-2db3A:
undetectable		 5mvnD-2db3A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 10 TYR A 202
PRO A 204
ILE A 332
ILE A 351
THR A 356
 None
 1.25A 5mzrA-2db3A:
undetectable		 5mzrA-2db3A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 10 TYR A 202
PRO A 204
ILE A 332
ILE A 351
THR A 356
 None
 1.23A 5mzrC-2db3A:
undetectable		 5mzrC-2db3A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		3 / 3 LYS A 340
LYS A 262
SER A 263
 ANP  A2901 ( 4.3A)
None
None
 1.26A 5odiA-2db3A:
undetectable		 5odiA-2db3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		4 / 6 PHE A 535
ARG A 533
LEU A 532
GLN A 530
 None
 1.08A 6b89B-2db3A:
3.6		 6b89B-2db3A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		5 / 9 VAL A 496
PHE A 508
SER A 507
LEU A 509
ILE A 544
 None
 0.72A 6fdyU-2db3A:
undetectable		 6fdyU-2db3A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2db3 ATP-DEPENDENT RNA
HELICASE VASA
(Drosophila
melanogaster) 		3 / 3 LEU A 509
SER A 507
PHE A 508
 None
 0.67A 6fgcA-2db3A:
undetectable		 6fgcA-2db3A:
22.48