SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dbr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 2dbr GLYOXYLATE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 7 ARG A 160
ASN A  73
ARG A 241
ASN A  80
 SO4  A 501 ( 2.7A)
None
SO4  A 507 ( 3.1A)
None
 1.48A 1f9gA-2dbrA:
undetectable		 1f9gA-2dbrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2dbr GLYOXYLATE REDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 198
GLY A 162
GLY A 159
ILE A 156
THR A 152
 None
None
NAP  A 401 (-3.5A)
None
None
 1.09A 1p91B-2dbrA:
5.9		 1p91B-2dbrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 2dbr GLYOXYLATE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 7 GLU A  26
ILE A  38
LEU A  49
TRP A  28
 None
 1.36A 1q0yH-2dbrA:
undetectable
1q0yL-2dbrA:
undetectable		 1q0yH-2dbrA:
19.00
1q0yL-2dbrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 2dbr GLYOXYLATE REDUCTASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 210
ILE A 156
GLY A 157
GLY A 162
LEU A 236
 None
None
NAP  A 401 ( 3.7A)
None
None
 1.01A 2qmmA-2dbrA:
2.8
2qmmB-2dbrA:
2.7		 2qmmA-2dbrA:
20.18
2qmmB-2dbrA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2dbr GLYOXYLATE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 198
TYR A 179
ILE A 153
ARG A 189
 None
NAP  A 401 ( 4.7A)
None
None
 1.20A 3ik3A-2dbrA:
undetectable		 3ik3A-2dbrA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2dbr GLYOXYLATE REDUCTASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 160
ASP A 102
ASP A  98
 SO4  A 501 ( 2.7A)
None
None
 0.87A 3jayA-2dbrA:
2.7		 3jayA-2dbrA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 2dbr GLYOXYLATE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 6 PHE A 278
PHE A 267
TYR A 272
VAL A 283
 None
 1.19A 3lb3B-2dbrA:
undetectable		 3lb3B-2dbrA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2dbr GLYOXYLATE REDUCTASE
(Pyrococcus
horikoshii) 		3 / 3 HIS A 220
VAL A 208
LEU A 210
 None
 0.72A 4m2vA-2dbrA:
undetectable		 4m2vA-2dbrA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2dbr GLYOXYLATE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 7 LYS A   1
LYS A   4
LEU A  68
PHE A  62
 None
 1.14A 4yv5B-2dbrA:
undetectable		 4yv5B-2dbrA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2dbr GLYOXYLATE REDUCTASE
(Pyrococcus
horikoshii) 		5 / 8 PRO A  12
VAL A  14
GLY A 295
ALA A 296
GLY A 299
 None
 1.09A 4zjzB-2dbrA:
6.1		 4zjzB-2dbrA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2dbr GLYOXYLATE REDUCTASE
(Pyrococcus
horikoshii) 		5 / 8 VAL A  50
ALA A 305
VAL A  25
PHE A   6
VAL A   5
 None
 1.44A 5l94A-2dbrA:
undetectable		 5l94A-2dbrA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2dbr GLYOXYLATE REDUCTASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A 210
ILE A 156
GLY A 157
GLY A 162
LEU A 236
 None
None
NAP  A 401 ( 3.7A)
None
None
 0.91A 5o96A-2dbrA:
3.4
5o96B-2dbrA:
3.4		 5o96A-2dbrA:
23.31
5o96B-2dbrA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2dbr GLYOXYLATE REDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 210
ILE A 156
GLY A 157
GLY A 162
LEU A 236
 None
None
NAP  A 401 ( 3.7A)
None
None
 0.95A 5twjA-2dbrA:
2.3		 5twjA-2dbrA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2dbr GLYOXYLATE REDUCTASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 210
ILE A 156
GLY A 157
GLY A 162
LEU A 236
 None
None
NAP  A 401 ( 3.7A)
None
None
 1.01A 5twjB-2dbrA:
2.3		 5twjB-2dbrA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2dbr GLYOXYLATE REDUCTASE
(Pyrococcus
horikoshii) 		5 / 8 GLY A 263
LEU A 264
LEU A 221
VAL A 245
GLY A 261
 None
 1.05A 5vkqB-2dbrA:
undetectable
5vkqC-2dbrA:
undetectable		 5vkqB-2dbrA:
11.15
5vkqC-2dbrA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 2dbr GLYOXYLATE REDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 221
VAL A 212
LEU A 111
THR A 104
LEU A 107
 None
NAP  A 401 ( 4.1A)
None
NAP  A 401 (-3.2A)
None
 1.07A 6b54A-2dbrA:
undetectable		 6b54A-2dbrA:
19.25