SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dby'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 7 PHE A 287
ALA A 309
GLU A 312
VAL A 364
 None
None
None
FMT  A 402 (-3.7A)
 0.91A 1hk2A-2dbyA:
undetectable		 1hk2A-2dbyA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 8 HIS A 105
TYR A 206
LEU A   9
GLU A 134
 FMT  A 401 (-4.0A)
None
None
None
 0.84A 1i7zA-2dbyA:
undetectable		 1i7zA-2dbyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 8 LEU A  50
LEU A 332
GLU A 294
TRP A 338
 None
 0.90A 1i7zA-2dbyA:
undetectable		 1i7zA-2dbyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 10 LEU A 150
ALA A 167
LEU A 163
LEU A 198
LEU A 193
 None
 1.21A 1ie4A-2dbyA:
undetectable
1ie4C-2dbyA:
undetectable		 1ie4A-2dbyA:
14.60
1ie4C-2dbyA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 10 LEU A 198
LEU A 193
LEU A 150
ALA A 167
LEU A 163
 None
 1.16A 1ie4A-2dbyA:
undetectable
1ie4C-2dbyA:
undetectable		 1ie4A-2dbyA:
14.60
1ie4C-2dbyA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 11 LEU A 150
ALA A 167
LEU A 163
LEU A 198
LEU A 193
 None
 1.17A 1tz8A-2dbyA:
undetectable
1tz8B-2dbyA:
undetectable		 1tz8A-2dbyA:
15.38
1tz8B-2dbyA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A  21
ASN A  25
ALA A  24
LEU A 274
THR A  35
 None
 1.43A 2aa6A-2dbyA:
undetectable		 2aa6A-2dbyA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 10 ASN A  19
GLU A 212
LEU A 215
LEU A 266
TYR A 264
 None
 1.34A 2ha6A-2dbyA:
2.1		 2ha6A-2dbyA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 10 ASN A  19
GLU A 212
LEU A 215
LEU A 266
TYR A 264
 None
 1.30A 2ha6B-2dbyA:
2.2		 2ha6B-2dbyA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 8 ALA A  20
LEU A 271
LEU A 274
ILE A   6
VAL A 207
 None
 1.31A 2uxpA-2dbyA:
undetectable		 2uxpA-2dbyA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 6 HIS A  84
GLN A 175
ALA A 138
ALA A 141
 None
 1.08A 2xfhA-2dbyA:
undetectable		 2xfhA-2dbyA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 7 GLY A 278
ALA A 104
ALA A 102
VAL A 207
 None
 0.73A 3a2qA-2dbyA:
undetectable		 3a2qA-2dbyA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 6 GLY A  90
GLU A  87
GLY A  82
ASN A  91
 None
 1.08A 3e9rA-2dbyA:
2.0		 3e9rA-2dbyA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 6 GLY A  90
GLU A  87
GLY A  82
ASN A  91
 None
 1.08A 3e9rC-2dbyA:
undetectable		 3e9rC-2dbyA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 7 LEU A 284
TYR A 279
VAL A 241
ILE A 205
 None
 1.31A 3ik3A-2dbyA:
undetectable		 3ik3A-2dbyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 7 LEU A 284
TYR A 279
VAL A 241
ILE A 205
 None
 1.29A 3ik3B-2dbyA:
undetectable		 3ik3B-2dbyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 9 ILE A   6
ALA A  20
THR A  16
VAL A 241
VAL A 106
 None
None
GDP  A 501 (-3.9A)
None
None
 1.17A 3me6D-2dbyA:
undetectable		 3me6D-2dbyA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 137
LEU A 140
ALA A 141
GLU A 144
GLY A  86
 None
 0.79A 3q95B-2dbyA:
undetectable		 3q95B-2dbyA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 8 ILE A 362
GLU A 355
THR A 304
LEU A 285
 None
 0.81A 3ua5A-2dbyA:
undetectable		 3ua5A-2dbyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 7 ILE A 362
GLU A 355
THR A 304
LEU A 285
 None
 0.65A 3ua5B-2dbyA:
undetectable		 3ua5B-2dbyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 7 GLU A 246
VAL A  43
LEU A  21
ALA A 250
 None
 1.02A 3uniA-2dbyA:
undetectable		 3uniA-2dbyA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 8 ILE A 103
ILE A  97
VAL A  80
GLY A  78
 FMT  A 401 ( 4.7A)
None
None
None
 0.78A 4acaC-2dbyA:
10.0		 4acaC-2dbyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 137
LEU A 140
ALA A 141
GLU A 144
GLY A  86
 None
 0.80A 4pxmA-2dbyA:
undetectable		 4pxmA-2dbyA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 12 ALA A  34
GLY A  41
ALA A 102
GLY A   5
GLU A  99
 None
 1.15A 4r29C-2dbyA:
undetectable		 4r29C-2dbyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 11 GLU A 259
ALA A 263
TYR A 264
GLU A 256
LEU A 249
 None
 1.04A 4wg0K-2dbyA:
undetectable
4wg0L-2dbyA:
undetectable
4wg0M-2dbyA:
undetectable		 4wg0K-2dbyA:
3.39
4wg0L-2dbyA:
3.39
4wg0M-2dbyA:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 7 VAL A   4
ILE A  76
ASN A  19
PHE A  73
 None
 0.98A 5hieC-2dbyA:
undetectable		 5hieC-2dbyA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 12 PHE A 110
LEU A 215
THR A  16
ALA A 247
LEU A 249
 GDP  A 501 (-4.1A)
None
GDP  A 501 (-3.9A)
None
None
 1.30A 5ienA-2dbyA:
undetectable		 5ienA-2dbyA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 10 ALA A 275
LEU A 274
GLY A 270
ILE A  97
LEU A 135
 None
 1.25A 5oy01-2dbyA:
undetectable
5oy07-2dbyA:
undetectable		 5oy01-2dbyA:
11.75
5oy07-2dbyA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 8 ILE A   6
VAL A   4
ALA A 281
TYR A 279
 None
 0.82A 6cduD-2dbyA:
1.8
6cduE-2dbyA:
1.8		 6cduD-2dbyA:
21.78
6cduE-2dbyA:
21.78