SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dc0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 10 GLU A  43
GLU A  42
LEU A  40
LEU A  21
GLU A  22
 None
 1.36A 1a29A-2dc0A:
undetectable		 1a29A-2dc0A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 SER A 163
VAL A  72
LEU A 104
GLY A 165
PHE A  76
 None
 1.42A 1fdsA-2dc0A:
undetectable		 1fdsA-2dc0A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 10 LEU A 264
VAL A 240
VAL A 237
GLY A 239
LEU A 260
 None
 1.38A 1fk9A-2dc0A:
undetectable		 1fk9A-2dc0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		3 / 3 GLN A 411
ILE A 228
HIS A 217
 None
 0.68A 1fm9A-2dc0A:
undetectable		 1fm9A-2dc0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 410
LEU A 429
PRO A 236
VAL A 233
VAL A 271
 None
 1.10A 1hrkA-2dc0A:
undetectable		 1hrkA-2dc0A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		3 / 3 GLN A 411
ILE A 228
HIS A 217
 None
 0.68A 1k74A-2dc0A:
undetectable		 1k74A-2dc0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 7 GLU A  42
LEU A  40
LEU A  21
GLU A  22
 None
 1.04A 1linA-2dc0A:
undetectable		 1linA-2dc0A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 7 PHE A 400
PRO A 354
ALA A 256
PHE A 257
 None
 1.04A 1lqtA-2dc0A:
undetectable		 1lqtA-2dc0A:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 7 PHE A 400
PRO A 354
ALA A 256
PHE A 257
 None
 1.04A 1lquA-2dc0A:
undetectable		 1lquA-2dc0A:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 7 GLU A 292
ARG A 338
LEU A 288
GLY A 392
 None
 0.91A 1mt1H-2dc0A:
undetectable
1mt1K-2dc0A:
undetectable		 1mt1H-2dc0A:
13.72
1mt1K-2dc0A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		3 / 3 PHE A 238
LEU A 429
LEU A 410
 None
 0.65A 1mx1E-2dc0A:
undetectable		 1mx1E-2dc0A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 7 GLU A 292
ARG A 338
LEU A 288
GLY A 392
 None
 0.89A 1n13D-2dc0A:
undetectable
1n13E-2dc0A:
undetectable		 1n13D-2dc0A:
13.72
1n13E-2dc0A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 8 LEU A 288
GLY A 392
GLU A 292
ARG A 338
 None
 0.88A 1n13A-2dc0A:
undetectable
1n13F-2dc0A:
undetectable		 1n13A-2dc0A:
8.76
1n13F-2dc0A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 6 GLU A 292
ARG A 338
LEU A 288
GLY A 392
 None
 0.90A 1n13H-2dc0A:
undetectable
1n13K-2dc0A:
undetectable		 1n13H-2dc0A:
13.72
1n13K-2dc0A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 7 LEU A 288
GLY A 392
GLU A 292
ARG A 338
 None
 0.90A 1n13G-2dc0A:
undetectable
1n13J-2dc0A:
undetectable		 1n13G-2dc0A:
8.76
1n13J-2dc0A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 HIS A 304
THR A  87
GLY A 307
GLU A 306
VAL A 312
 None
 1.21A 1n2xA-2dc0A:
undetectable		 1n2xA-2dc0A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 288
VAL A 289
SER A 200
SER A 389
VAL A 281
 None
 1.38A 1rk3A-2dc0A:
0.0		 1rk3A-2dc0A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 6 LEU A 260
PHE A 257
ALA A 256
LEU A 433
 None
 0.83A 1ukbA-2dc0A:
undetectable		 1ukbA-2dc0A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 6 ILE A 124
GLY A 145
ALA A 144
HIS A 118
 None
 0.98A 1wmqA-2dc0A:
undetectable		 1wmqA-2dc0A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 6 ILE A 124
GLY A 145
ALA A 144
HIS A 118
 None
 0.99A 1wmqB-2dc0A:
undetectable		 1wmqB-2dc0A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 6 ILE A 124
GLY A 145
ALA A 144
HIS A 118
 None
 0.97A 1wpuA-2dc0A:
undetectable		 1wpuA-2dc0A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 6 ILE A 124
GLY A 145
ALA A 144
HIS A 118
 None
 0.97A 1wpuB-2dc0A:
undetectable		 1wpuB-2dc0A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 10 LEU A   3
PHE A 218
LEU A  70
LEU A 104
ILE A 222
 None
 0.99A 2bxeB-2dc0A:
undetectable		 2bxeB-2dc0A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 10 LEU A 352
VAL A 422
GLY A 414
TRP A 428
LEU A 429
 None
 1.47A 2hndA-2dc0A:
undetectable		 2hndA-2dc0A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 410
LEU A 429
PRO A 236
VAL A 233
VAL A 271
 None
 0.98A 2po5A-2dc0A:
undetectable		 2po5A-2dc0A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 11 LEU A 410
LEU A 429
PRO A 236
VAL A 233
VAL A 271
 None
 1.01A 2po5B-2dc0A:
undetectable		 2po5B-2dc0A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 410
LEU A 429
PRO A 236
VAL A 233
VAL A 271
 None
 0.98A 2po7A-2dc0A:
undetectable		 2po7A-2dc0A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 410
LEU A 429
PRO A 236
VAL A 233
VAL A 271
 None
 1.03A 2qd4A-2dc0A:
undetectable		 2qd4A-2dc0A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 410
LEU A 429
PRO A 236
VAL A 233
VAL A 271
 None
 1.09A 2qd4B-2dc0A:
undetectable		 2qd4B-2dc0A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 7 LEU A  68
LEU A  65
LEU A  10
GLU A  11
 None
 0.94A 2vq5B-2dc0A:
undetectable		 2vq5B-2dc0A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 8 GLN A 411
TYR A 282
ARG A 248
THR A 286
 None
 1.35A 2vxaF-2dc0A:
undetectable
2vxaG-2dc0A:
undetectable
2vxaI-2dc0A:
undetectable		 2vxaF-2dc0A:
9.68
2vxaG-2dc0A:
9.68
2vxaI-2dc0A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 353
GLY A 170
ARG A 378
PHE A 244
LEU A 278
 None
 1.30A 2w8yA-2dc0A:
undetectable		 2w8yA-2dc0A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 7 GLN A 143
GLY A 364
HIS A 118
HIS A 377
 None
 0.77A 3ai8A-2dc0A:
undetectable		 3ai8A-2dc0A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 7 ARG A   8
VAL A 182
LEU A 161
LEU A 164
 None
 0.92A 3gp0A-2dc0A:
undetectable		 3gp0A-2dc0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 4 LEU A 260
ALA A 401
VAL A 408
PRO A 399
 None
 1.08A 3gv1B-2dc0A:
undetectable		 3gv1B-2dc0A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 GLU A 292
GLY A 189
ARG A 334
GLY A 169
ARG A 173
 None
 1.43A 3jzjA-2dc0A:
1.2		 3jzjA-2dc0A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 4 LEU A 396
GLY A 426
LEU A 429
GLU A 430
 None
 0.98A 3tgvB-2dc0A:
undetectable		 3tgvB-2dc0A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 11 GLY A 177
ALA A 176
GLY A 149
GLY A 146
ILE A 124
 None
 0.85A 3ufnA-2dc0A:
undetectable		 3ufnA-2dc0A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 5 ARG A 105
LEU A 111
PRO A  77
VAL A  78
 None
 1.07A 3ufnA-2dc0A:
undetectable
3ufnB-2dc0A:
undetectable		 3ufnA-2dc0A:
11.57
3ufnB-2dc0A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 288
VAL A 289
SER A 200
SER A 389
VAL A 281
 None
 1.32A 3vt3A-2dc0A:
undetectable		 3vt3A-2dc0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 288
VAL A 289
SER A 200
SER A 389
VAL A 281
 None
 1.31A 3vt7A-2dc0A:
undetectable		 3vt7A-2dc0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 410
LEU A 429
PRO A 236
VAL A 233
VAL A 271
 None
 1.13A 3w1wB-2dc0A:
undetectable		 3w1wB-2dc0A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 161
ALA A 162
LEU A 223
LEU A 219
ILE A 222
 None
 1.09A 4dm8B-2dc0A:
undetectable		 4dm8B-2dc0A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 7 ALA A 206
PHE A  76
ALA A 196
LEU A 193
 None
 0.82A 4du2A-2dc0A:
undetectable		 4du2A-2dc0A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 7 ALA A 206
PHE A  76
ALA A 196
LEU A 193
 None
 0.91A 4du2B-2dc0A:
undetectable		 4du2B-2dc0A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 377
GLY A 145
ILE A 124
 None
 0.62A 4k50I-2dc0A:
undetectable		 4k50I-2dc0A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		3 / 3 LEU A  68
PRO A  69
ARG A 214
 None
 0.58A 4klrB-2dc0A:
undetectable		 4klrB-2dc0A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 9 PRO A 133
ALA A 144
GLY A  86
SER A 147
GLY A 126
 None
 1.21A 4mm5A-2dc0A:
undetectable		 4mm5A-2dc0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 9 PRO A 133
ALA A 144
GLY A  86
SER A 147
GLY A 126
 None
 1.19A 4mmbA-2dc0A:
undetectable		 4mmbA-2dc0A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 PRO A 133
ALA A 144
GLY A  86
SER A 147
GLY A 126
 None
 1.19A 4mmdB-2dc0A:
0.3		 4mmdB-2dc0A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 8 LEU A  56
GLU A  55
GLU A  48
ALA A  45
 None
 0.89A 4rjdA-2dc0A:
undetectable
4rjdB-2dc0A:
undetectable		 4rjdA-2dc0A:
10.07
4rjdB-2dc0A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 ALA A 156
GLY A 183
GLN A 356
GLY A 409
PRO A 407
 None
 1.22A 4uilH-2dc0A:
undetectable
4uilL-2dc0A:
undetectable		 4uilH-2dc0A:
17.33
4uilL-2dc0A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 LEU A  21
ALA A  45
LEU A  40
ALA A  28
ALA A  24
 None
 1.10A 4x1iB-2dc0A:
undetectable		 4x1iB-2dc0A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 4 ASN A 179
SER A 148
ALA A 152
VAL A 155
 None
 1.32A 4x1kC-2dc0A:
undetectable		 4x1kC-2dc0A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 7 LEU A 164
ALA A 109
ALA A 107
LEU A 223
ALA A 100
 None
 1.34A 4z90F-2dc0A:
undetectable
4z90G-2dc0A:
undetectable
4z90H-2dc0A:
undetectable
4z90J-2dc0A:
undetectable		 4z90F-2dc0A:
21.14
4z90G-2dc0A:
21.14
4z90H-2dc0A:
21.14
4z90J-2dc0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 VAL A  78
GLU A  97
LEU A  70
LEU A 219
THR A 220
 None
 1.32A 5hnxB-2dc0A:
undetectable		 5hnxB-2dc0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 4 ASN A 179
SER A 148
ALA A 152
VAL A 155
 None
 1.37A 5nm5A-2dc0A:
undetectable		 5nm5A-2dc0A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		6 / 12 LEU A 433
TRP A 428
LEU A 410
PRO A 265
ALA A 269
LEU A 261
 None
 1.40A 5og9B-2dc0A:
undetectable		 5og9B-2dc0A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		5 / 12 GLU A 404
VAL A 403
LEU A 245
ALA A 256
GLY A 177
 None
 1.26A 5syeB-2dc0A:
undetectable		 5syeB-2dc0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 7 VAL A 312
HIS A 297
ILE A 296
SER A 147
 None
 0.84A 5vkqA-2dc0A:
undetectable
5vkqD-2dc0A:
undetectable		 5vkqA-2dc0A:
13.95
5vkqD-2dc0A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 7 SER A 147
VAL A 312
HIS A 297
ILE A 296
 None
 0.86A 5vkqA-2dc0A:
undetectable
5vkqB-2dc0A:
undetectable		 5vkqA-2dc0A:
13.95
5vkqB-2dc0A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 8 SER A 147
VAL A 312
HIS A 297
ILE A 296
 None
 0.85A 5vkqB-2dc0A:
undetectable
5vkqC-2dc0A:
undetectable		 5vkqB-2dc0A:
13.95
5vkqC-2dc0A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		4 / 7 SER A 147
VAL A 312
HIS A 297
ILE A 296
 None
 0.83A 5vkqC-2dc0A:
undetectable
5vkqD-2dc0A:
undetectable		 5vkqC-2dc0A:
13.95
5vkqD-2dc0A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dc0 PROBABLE AMIDASE
(Thermus
thermophilus) 		3 / 3 GLN A 411
ILE A 228
HIS A 217
 None
 0.71A 5z12B-2dc0A:
undetectable		 5z12B-2dc0A:
11.16