SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dc1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 GLY A   4
LEU A  47
ILE A  70
ILE A  78
LEU A  77
 None
 1.21A 1kyvA-2dc1A:
3.1
1kyvE-2dc1A:
4.9		 1kyvA-2dc1A:
23.43
1kyvE-2dc1A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A  78
LEU A  77
GLY A   4
LEU A  47
ILE A  70
 None
 1.23A 1kyvB-2dc1A:
3.1
1kyvC-2dc1A:
3.0		 1kyvB-2dc1A:
23.43
1kyvC-2dc1A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A  78
LEU A  77
GLY A   4
LEU A  47
ILE A  70
 None
 1.22A 1kyvC-2dc1A:
3.0
1kyvD-2dc1A:
4.0		 1kyvC-2dc1A:
23.43
1kyvD-2dc1A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A  78
LEU A  77
GLY A   4
LEU A  47
ILE A  70
 None
 1.22A 1kyvD-2dc1A:
5.2
1kyvE-2dc1A:
5.0		 1kyvD-2dc1A:
23.43
1kyvE-2dc1A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		3 / 3 LEU A  91
PHE A  85
ARG A 103
 None
 0.82A 1xdkB-2dc1A:
undetectable		 1xdkB-2dc1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		3 / 3 LEU A  91
PHE A  85
ARG A 103
 None
 0.82A 1xdkF-2dc1A:
undetectable		 1xdkF-2dc1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 11 ILE A   6
ALA A  58
ALA A  57
LEU A  80
ILE A  75
 None
NAD  A 242 (-3.5A)
NAD  A 242 ( 4.9A)
NAD  A 242 (-4.1A)
None
 1.08A 2aclE-2dc1A:
undetectable		 2aclE-2dc1A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 11 ILE A  43
ALA A  62
LEU A  77
ILE A  70
PHE A  46
 None
NAD  A 242 (-3.4A)
None
None
None
 1.05A 2w9sA-2dc1A:
undetectable		 2w9sA-2dc1A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 11 LEU A  80
ALA A 111
ALA A 219
VAL A  55
LEU A  15
 NAD  A 242 (-4.1A)
CIT  A1585 ( 3.1A)
NAD  A 242 (-3.2A)
None
None
 1.09A 3bszE-2dc1A:
undetectable		 3bszE-2dc1A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 10 ASN A 206
VAL A 177
ALA A 111
ILE A 112
LEU A 167
 None
None
CIT  A1585 ( 3.1A)
None
None
 1.15A 3fl9F-2dc1A:
undetectable		 3fl9F-2dc1A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		6 / 12 LEU A  47
GLY A   4
ALA A  54
VAL A  79
ILE A  43
ILE A  70
 None
 1.50A 3s54A-2dc1A:
undetectable		 3s54A-2dc1A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 THR A 101
LEU A  77
VAL A  63
PHE A  85
VAL A 105
 None
 1.13A 3u9fB-2dc1A:
undetectable
3u9fC-2dc1A:
undetectable		 3u9fB-2dc1A:
20.33
3u9fC-2dc1A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 9 THR A 101
LEU A  77
VAL A  63
PHE A  85
VAL A 105
 None
 1.13A 3u9fP-2dc1A:
undetectable		 3u9fP-2dc1A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 218
SER A 216
ILE A 118
ILE A 202
VAL A 204
 None
CIT  A1585 (-2.6A)
None
None
None
 1.15A 3w67D-2dc1A:
undetectable		 3w67D-2dc1A:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 GLY A   4
ALA A  54
ILE A  26
GLU A  20
LEU A  30
 None
None
None
None
NAD  A 242 ( 4.7A)
 1.28A 4azsA-2dc1A:
3.8		 4azsA-2dc1A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 128
THR A 166
LEU A 115
GLY A 113
VAL A 163
 None
None
None
None
CIT  A1585 (-4.1A)
 1.02A 4c9lB-2dc1A:
undetectable		 4c9lB-2dc1A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 128
THR A 166
LEU A 115
GLY A 113
VAL A 163
 None
None
None
None
CIT  A1585 (-4.1A)
 1.02A 4c9oA-2dc1A:
undetectable		 4c9oA-2dc1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 128
THR A 166
LEU A 115
GLY A 113
VAL A 163
 None
None
None
None
CIT  A1585 (-4.1A)
 1.02A 4c9oB-2dc1A:
undetectable		 4c9oB-2dc1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 11 ILE A  43
ILE A   6
ALA A  28
ALA A  27
ILE A  75
 None
 1.17A 4h1nA-2dc1A:
undetectable		 4h1nA-2dc1A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 TYR A 217
ASP A  31
GLU A 211
GLY A  12
GLY A   7
 None
NAD  A 242 (-2.9A)
None
None
NAD  A 242 (-3.6A)
 1.27A 4hfpB-2dc1A:
undetectable		 4hfpB-2dc1A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7T_A_SAMA503_0
(BTRN)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 11 THR A 132
HIS A 189
LEU A 130
LEU A 167
SER A 168
 None
CIT  A1585 (-4.2A)
None
None
None
 1.31A 4m7tA-2dc1A:
0.9		 4m7tA-2dc1A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  80
ALA A  57
LEU A  15
ILE A 226
ALA A 108
 NAD  A 242 (-4.1A)
NAD  A 242 ( 4.9A)
None
None
None
 0.97A 4o2bD-2dc1A:
undetectable		 4o2bD-2dc1A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 8 ALA A 165
SER A 168
ALA A  86
ALA A 153
 None
 0.78A 4twdF-2dc1A:
undetectable
4twdG-2dc1A:
undetectable
4twdH-2dc1A:
undetectable
4twdI-2dc1A:
undetectable
4twdJ-2dc1A:
undetectable		 4twdF-2dc1A:
22.04
4twdG-2dc1A:
22.04
4twdH-2dc1A:
22.04
4twdI-2dc1A:
22.04
4twdJ-2dc1A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 ALA A  84
GLY A  83
SER A  81
PHE A  90
ASP A  65
 None
None
NAD  A 242 (-2.9A)
None
None
 1.19A 5w7pA-2dc1A:
undetectable		 5w7pA-2dc1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 2dc1 L-ASPARTATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  80
ALA A  57
LEU A  15
ILE A 226
ALA A 108
 NAD  A 242 (-4.1A)
NAD  A 242 ( 4.9A)
None
None
None
 0.96A 5xiwB-2dc1A:
4.0		 5xiwB-2dc1A:
19.23