SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dc2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2dc2 GOLGI ASSOCIATED PDZ
AND COILED-COIL
MOTIF CONTAINING
ISOFORM B
(Homo
sapiens) 		5 / 11 GLY A  24
ILE A  25
SER A  26
VAL A  77
LEU A  80
 None
 0.90A 2kawA-2dc2A:
12.2		 2kawA-2dc2A:
31.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 2dc2 GOLGI ASSOCIATED PDZ
AND COILED-COIL
MOTIF CONTAINING
ISOFORM B
(Homo
sapiens) 		5 / 10 ILE A  60
ALA A  62
GLU A  90
PHE A  89
LEU A  23
 None
 1.22A 2w3aB-2dc2A:
undetectable		 2w3aB-2dc2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 2dc2 GOLGI ASSOCIATED PDZ
AND COILED-COIL
MOTIF CONTAINING
ISOFORM B
(Homo
sapiens) 		5 / 12 ILE A  60
ALA A  62
GLU A  90
PHE A  89
LEU A  23
 None
 1.20A 4cd2A-2dc2A:
undetectable		 4cd2A-2dc2A:
16.99