SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dc4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2dc4 165AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 GLU A  12
GLU A  19
LEU A 124
 None
 0.68A 1v8bA-2dc4A:
undetectable		 1v8bA-2dc4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2dc4 165AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 GLU A  12
GLU A  19
LEU A 124
 None
 0.65A 1v8bB-2dc4A:
undetectable		 1v8bB-2dc4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 2dc4 165AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 VAL A 110
ASN A 109
VAL A 143
ILE A 140
 None
 1.05A 1z2bC-2dc4A:
undetectable		 1z2bC-2dc4A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 2dc4 165AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A  18
LEU A  21
ILE A 126
VAL A   9
LEU A 149
 None
 1.10A 3a51C-2dc4A:
undetectable		 3a51C-2dc4A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 2dc4 165AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 GLU A  72
ARG A 102
ARG A  47
GLU A  74
 None
CL  A 502 ( 3.3A)
CL  A 502 (-3.6A)
None
 1.00A 3tj7C-2dc4A:
13.2		 3tj7C-2dc4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 2dc4 165AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 GLU A 127
ARG A  47
LYS A  60
ARG A 102
 None
CL  A 502 (-3.6A)
CL  A 502 ( 3.8A)
CL  A 502 ( 3.3A)
 0.95A 3tj7C-2dc4A:
13.2		 3tj7C-2dc4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 2dc4 165AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 GLU A 127
ARG A  47
LYS A  60
GLU A 113
 None
CL  A 502 (-3.6A)
CL  A 502 ( 3.8A)
CL  A 502 ( 4.4A)
 1.34A 3tj7C-2dc4A:
13.2		 3tj7C-2dc4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 2dc4 165AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 VAL A 117
GLY A 121
LEU A 158
LYS A 157
ASP A  33
 None
None
CL  A 501 (-4.0A)
None
None
 1.40A 6c2mC-2dc4A:
undetectable		 6c2mC-2dc4A:
20.13