SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2dch PUTATIVE HOMING
ENDONUCLEASE
(Thermoproteus) 		5 / 12 ILE X  25
GLN X  27
GLY X 101
LEU X  39
LEU X   7
 None
 1.10A 1rjdA-2dchX:
undetectable		 1rjdA-2dchX:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2dch PUTATIVE HOMING
ENDONUCLEASE
(Thermoproteus) 		5 / 12 ILE X  25
GLN X  27
GLY X 101
LEU X  39
LEU X   7
 None
 1.10A 1rjdB-2dchX:
undetectable		 1rjdB-2dchX:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2dch PUTATIVE HOMING
ENDONUCLEASE
(Thermoproteus) 		5 / 12 TYR X   6
ALA X 140
ILE X 139
ALA X 168
LEU X 175
 None
 1.32A 1udtA-2dchX:
undetectable		 1udtA-2dchX:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2dch PUTATIVE HOMING
ENDONUCLEASE
(Thermoproteus) 		3 / 3 ASP X  14
ILE X 100
VAL X 109
 None
 0.59A 2avvD-2dchX:
undetectable		 2avvD-2dchX:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2dch PUTATIVE HOMING
ENDONUCLEASE
(Thermoproteus) 		3 / 3 ASP X  94
ILE X 139
VAL X  77
 SO4  X 302 ( 4.7A)
None
None
 0.52A 2avvD-2dchX:
undetectable		 2avvD-2dchX:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2dch PUTATIVE HOMING
ENDONUCLEASE
(Thermoproteus) 		5 / 7 GLN X  27
GLY X 107
GLY X 105
THR X 179
GLU X 160
 None
 1.14A 3fpjB-2dchX:
undetectable		 3fpjB-2dchX:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2dch PUTATIVE HOMING
ENDONUCLEASE
(Thermoproteus) 		5 / 12 THR X 142
LEU X 135
ILE X 103
ILE X 128
LEU X 146
 None
 1.33A 3gwxA-2dchX:
undetectable		 3gwxA-2dchX:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2dch PUTATIVE HOMING
ENDONUCLEASE
(Thermoproteus) 		4 / 8 ILE X 100
LEU X 171
ILE X 139
GLY X 147
 None
 0.84A 4hb8A-2dchX:
undetectable		 4hb8A-2dchX:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 2dch PUTATIVE HOMING
ENDONUCLEASE
(Thermoproteus) 		4 / 6 SER X 132
GLY X 105
ASP X  14
GLY X   9
 None
 0.99A 4koeA-2dchX:
2.8
4koeB-2dchX:
2.8
4koeC-2dchX:
undetectable		 4koeA-2dchX:
19.51
4koeB-2dchX:
19.51
4koeC-2dchX:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 2dch PUTATIVE HOMING
ENDONUCLEASE
(Thermoproteus) 		5 / 9 VAL X  37
ILE X  36
LEU X   7
ILE X  33
GLY X  15
 None
 1.12A 4kukA-2dchX:
undetectable		 4kukA-2dchX:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dch PUTATIVE HOMING
ENDONUCLEASE
(Thermoproteus) 		5 / 11 LEU X  17
LEU X  72
CYH X   8
PRO X  89
VAL X  93
 None
 1.46A 4mk4B-2dchX:
0.1		 4mk4B-2dchX:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2dch PUTATIVE HOMING
ENDONUCLEASE
(Thermoproteus) 		3 / 3 ARG X  31
ASP X  34
ARG X  30
 None
 0.65A 4wq4B-2dchX:
undetectable		 4wq4B-2dchX:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2dch PUTATIVE HOMING
ENDONUCLEASE
(Thermoproteus) 		4 / 6 GLY X 105
ASP X  14
GLY X   9
SER X 132
 None
 1.02A 4z53A-2dchX:
2.5
4z53B-2dchX:
2.5		 4z53A-2dchX:
15.78
4z53B-2dchX:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2dch PUTATIVE HOMING
ENDONUCLEASE
(Thermoproteus) 		5 / 10 GLY X 107
VAL X 109
VAL X 172
ALA X 168
LEU X 175
 None
 1.03A 6czmA-2dchX:
undetectable
6czmC-2dchX:
undetectable		 6czmA-2dchX:
21.69
6czmC-2dchX:
21.69