SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dcl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 2dcl HYPOTHETICAL UPF0166
PROTEIN PH1503
(Pyrococcus
horikoshii) 		5 / 12 VAL A  30
ILE A  94
ILE A  14
VAL A  76
ILE A  99
 None
None
None
AMP  A 901 ( 4.5A)
None
 1.37A 1r5lA-2dclA:
undetectable		 1r5lA-2dclA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 2dcl HYPOTHETICAL UPF0166
PROTEIN PH1503
(Pyrococcus
horikoshii) 		3 / 3 PRO A 103
LEU A  10
ARG A  79
 None
 0.90A 3aqiA-2dclA:
undetectable		 3aqiA-2dclA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2dcl HYPOTHETICAL UPF0166
PROTEIN PH1503
(Pyrococcus
horikoshii) 		5 / 12 VAL A  30
ILE A  16
ILE A  14
VAL A  76
LEU A  12
 None
None
None
AMP  A 901 ( 4.5A)
None
 0.87A 3w67D-2dclA:
undetectable		 3w67D-2dclA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 2dcl HYPOTHETICAL UPF0166
PROTEIN PH1503
(Pyrococcus
horikoshii) 		5 / 11 ILE A  83
ILE A  40
ALA A  43
ILE A  90
VAL A  86
 None
None
AMP  A 901 (-4.9A)
None
None
 1.01A 4h1nA-2dclA:
undetectable		 4h1nA-2dclA:
18.93