SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ddh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		4 / 7 THR A 110
LEU A 108
GLY A 105
LEU A 102
 None
None
None
FAD  A 699 (-4.4A)
 0.94A 1gtiB-2ddhA:
undetectable		 1gtiB-2ddhA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		4 / 7 THR A 110
LEU A 108
GLY A 105
LEU A 102
 None
None
None
FAD  A 699 (-4.4A)
 1.03A 1gtiD-2ddhA:
undetectable		 1gtiD-2ddhA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		4 / 7 THR A 110
LEU A 108
GLY A 105
LEU A 102
 None
None
None
FAD  A 699 (-4.4A)
 1.00A 1gtiE-2ddhA:
undetectable		 1gtiE-2ddhA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		5 / 12 PHE A 205
LEU A 165
ALA A 191
LEU A 202
ILE A 194
 None
 1.28A 1mx8A-2ddhA:
undetectable		 1mx8A-2ddhA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		4 / 7 ASP A 225
TYR A 232
MET A 235
ASP A 236
 None
FAD  A 699 ( 3.8A)
None
None
 1.31A 1t03A-2ddhA:
undetectable		 1t03A-2ddhA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		5 / 11 LEU A 240
GLY A 181
ILE A 209
ARG A 210
HIS A 215
 None
 1.28A 1tmxA-2ddhA:
undetectable		 1tmxA-2ddhA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		4 / 8 ASP A 541
TYR A 347
TYR A 533
HIS A 530
 None
 1.42A 2ha2A-2ddhA:
undetectable		 2ha2A-2ddhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		4 / 8 ASP A 541
TYR A 347
TYR A 533
HIS A 530
 None
 1.40A 2ha2B-2ddhA:
undetectable		 2ha2B-2ddhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		5 / 12 SER A 167
SER A 172
VAL A 189
ALA A 137
THR A 135
 None
 1.26A 2nniA-2ddhA:
2.1		 2nniA-2ddhA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		4 / 6 THR A 135
TYR A 232
TRP A 176
THR A 183
 None
FAD  A 699 ( 3.8A)
FAD  A 699 (-4.0A)
None
 1.46A 2qmjA-2ddhA:
0.0		 2qmjA-2ddhA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		5 / 11 PHE A 280
LEU A 111
ALA A 204
MET A 278
GLU A 421
 None
None
None
None
HXD  A 900 (-3.5A)
 1.41A 2v0mA-2ddhA:
undetectable		 2v0mA-2ddhA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		5 / 12 GLY A 134
GLY A 179
LEU A 180
PRO A 208
ASN A 185
 None
 0.94A 3av6A-2ddhA:
undetectable		 3av6A-2ddhA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		4 / 8 PHE A 343
GLY A 345
VAL A 286
LEU A 377
 None
 0.82A 3bgdB-2ddhA:
undetectable		 3bgdB-2ddhA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		3 / 3 SER A 184
GLY A 181
GLY A 178
 None
None
FAD  A 699 (-4.2A)
 0.46A 3bogA-2ddhA:
undetectable
3bogC-2ddhA:
undetectable		 3bogA-2ddhA:
undetectable
3bogC-2ddhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		4 / 7 PHE A 341
VAL A 344
ASN A 288
GLY A 287
 None
 1.07A 3kmoB-2ddhA:
undetectable		 3kmoB-2ddhA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		3 / 3 SER A 184
ASP A 236
ASN A 237
 None
None
FAD  A 699 (-4.0A)
 0.99A 3lsfB-2ddhA:
undetectable
3lsfE-2ddhA:
undetectable		 3lsfB-2ddhA:
17.64
3lsfE-2ddhA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		5 / 11 ASP A   4
LEU A   5
VAL A 604
ALA A 603
PHE A 324
 None
 1.23A 3n23C-2ddhA:
undetectable		 3n23C-2ddhA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		4 / 8 ARG A 249
GLU A 250
GLU A 162
ARG A 246
 None
 1.21A 4bqfB-2ddhA:
undetectable		 4bqfB-2ddhA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		3 / 3 TYR A 487
HIS A 532
ARG A 490
 None
 1.21A 4e7bC-2ddhA:
undetectable		 4e7bC-2ddhA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		3 / 3 GLU A  98
ASP A 101
ASP A 236
 None
HXD  A 900 (-3.1A)
None
 0.79A 4gc9A-2ddhA:
undetectable		 4gc9A-2ddhA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		4 / 7 ASP A 608
LEU A 335
GLN A 327
LEU A 322
 None
 1.08A 4ib4A-2ddhA:
2.6		 4ib4A-2ddhA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		4 / 6 SER A  67
GLY A 181
ASP A 225
GLY A 178
 None
None
None
FAD  A 699 (-4.2A)
 1.04A 4koeA-2ddhA:
undetectable
4koeB-2ddhA:
undetectable
4koeC-2ddhA:
undetectable		 4koeA-2ddhA:
22.29
4koeB-2ddhA:
22.29
4koeC-2ddhA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		4 / 6 THR A  13
LEU A 335
GLN A 327
LEU A 322
 None
 1.22A 4nc3A-2ddhA:
2.7		 4nc3A-2ddhA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		4 / 8 TYR A 565
THR A 384
CYH A 392
LEU A 293
 None
 1.42A 5kxiA-2ddhA:
3.1
5kxiB-2ddhA:
3.6		 5kxiA-2ddhA:
21.21
5kxiB-2ddhA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		4 / 8 TYR A 565
THR A 384
CYH A 392
LEU A 293
 None
 1.45A 5kxiD-2ddhA:
4.0
5kxiE-2ddhA:
3.5		 5kxiD-2ddhA:
21.21
5kxiE-2ddhA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		3 / 3 THR A 183
HIS A 215
ASN A 185
 None
 0.90A 5n4tA-2ddhA:
undetectable		 5n4tA-2ddhA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		4 / 5 ASP A 611
ARG A  33
ARG A  34
LEU A 555
 None
 1.34A 5tuiB-2ddhA:
0.0		 5tuiB-2ddhA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		5 / 12 LEU A 558
PHE A 612
ILE A 599
ALA A 300
ILE A 299
 None
 0.96A 5veuB-2ddhA:
undetectable		 5veuB-2ddhA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		3 / 3 ARG A 493
LYS A 500
TYR A 439
 None
 0.92A 6gnaA-2ddhA:
undetectable		 6gnaA-2ddhA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2ddh ACYL-COA OXIDASE
(Rattus
norvegicus) 		3 / 3 ARG A 493
LYS A 500
TYR A 439
 None
 0.92A 6gnbA-2ddhA:
undetectable		 6gnbA-2ddhA:
18.15