SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ddu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 2ddu REELIN
(Mus
musculus) 		5 / 12 LEU A1592
ALA A1494
GLY A1468
LEU A1532
PHE A1455
 None
 1.41A 1brpA-2dduA:
undetectable		 1brpA-2dduA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 2ddu REELIN
(Mus
musculus) 		3 / 3 TRP A1590
TYR A1485
LEU A1478
 None
 0.78A 1kxhA-2dduA:
undetectable		 1kxhA-2dduA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2ddu REELIN
(Mus
musculus) 		4 / 8 ILE A1561
ILE A1563
ILE A1597
ILE A1511
 None
 0.66A 2nniA-2dduA:
undetectable		 2nniA-2dduA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2ddu REELIN
(Mus
musculus) 		4 / 4 LEU A1543
ALA A1375
VAL A1301
PRO A1412
 None
 1.23A 3gv1B-2dduA:
undetectable		 3gv1B-2dduA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 2ddu REELIN
(Mus
musculus) 		4 / 7 TYR A1510
PRO A1558
GLN A1512
GLU A1557
 None
 1.27A 3s3oA-2dduA:
undetectable		 3s3oA-2dduA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 2ddu REELIN
(Mus
musculus) 		5 / 9 LEU A1302
GLY A1338
PRO A1377
ILE A1376
ILE A1374
 None
 0.99A 3s56B-2dduA:
undetectable		 3s56B-2dduA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 2ddu REELIN
(Mus
musculus) 		5 / 12 LEU A1459
GLY A1488
LEU A1484
GLY A1364
ASP A1365
 None
 1.03A 3uq6A-2dduA:
undetectable		 3uq6A-2dduA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2ddu REELIN
(Mus
musculus) 		5 / 12 THR A1496
SER A1418
ASP A1539
VAL A1442
PRO A1572
 None
 1.05A 3v8vA-2dduA:
undetectable		 3v8vA-2dduA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 2ddu REELIN
(Mus
musculus) 		5 / 12 LEU A1459
GLY A1488
LEU A1484
GLY A1364
ASP A1365
 None
 1.00A 4dc3A-2dduA:
undetectable		 4dc3A-2dduA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ddu REELIN
(Mus
musculus) 		4 / 5 ARG A1454
VAL A1471
LEU A1484
SER A1483
 None
 1.33A 4e1gA-2dduA:
undetectable		 4e1gA-2dduA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 2ddu REELIN
(Mus
musculus) 		5 / 9 GLY A1519
SER A1518
TYR A1485
SER A1515
THR A1521
 None
 1.32A 4lb0A-2dduA:
0.0		 4lb0A-2dduA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 2ddu REELIN
(Mus
musculus) 		4 / 6 HIS A1420
GLY A1421
ARG A1371
ASN A1540
 None
 1.37A 4zbqA-2dduA:
undetectable		 4zbqA-2dduA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 2ddu REELIN
(Mus
musculus) 		5 / 12 LEU A1459
GLY A1488
LEU A1484
GLY A1364
ASP A1365
 None
 1.03A 5kb5A-2dduA:
undetectable		 5kb5A-2dduA:
21.56