SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ddx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 2ddx BETA-1,3-XYLANASE
(Vibrio
sp.
AX-4) 		5 / 12 PHE A 319
LEU A 318
ALA A  72
LEU A  73
ILE A  32
 None
 1.11A 1mx8A-2ddxA:
undetectable		 1mx8A-2ddxA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2ddx BETA-1,3-XYLANASE
(Vibrio
sp.
AX-4) 		5 / 12 ASN A  80
ILE A  95
LEU A 111
ALA A  87
SER A 132
 None
 1.18A 2iyfB-2ddxA:
undetectable		 2iyfB-2ddxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2ddx BETA-1,3-XYLANASE
(Vibrio
sp.
AX-4) 		5 / 12 GLU A 116
GLY A 119
VAL A 176
GLY A 180
SER A 182
 None
 1.14A 3k13A-2ddxA:
5.4		 3k13A-2ddxA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2ddx BETA-1,3-XYLANASE
(Vibrio
sp.
AX-4) 		5 / 12 GLU A 116
GLY A 119
VAL A 176
GLY A 180
SER A 182
 None
 1.17A 3k13C-2ddxA:
5.5		 3k13C-2ddxA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2ddx BETA-1,3-XYLANASE
(Vibrio
sp.
AX-4) 		3 / 3 SER A 274
ASP A  53
ASP A  46
 None
 0.87A 3uj7A-2ddxA:
undetectable		 3uj7A-2ddxA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2ddx BETA-1,3-XYLANASE
(Vibrio
sp.
AX-4) 		3 / 3 TYR A 225
ARG A 217
SER A 226
 None
 1.05A 4dr2I-2ddxA:
undetectable
4dr2J-2ddxA:
undetectable		 4dr2I-2ddxA:
17.58
4dr2J-2ddxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2ddx BETA-1,3-XYLANASE
(Vibrio
sp.
AX-4) 		5 / 11 ASN A  80
ILE A  95
LEU A 111
ALA A  87
SER A 132
 None
 1.17A 4m83A-2ddxA:
undetectable		 4m83A-2ddxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2ddx BETA-1,3-XYLANASE
(Vibrio
sp.
AX-4) 		3 / 3 VAL A 155
VAL A 117
GLN A 168
 None
 0.69A 5qglA-2ddxA:
undetectable		 5qglA-2ddxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2ddx BETA-1,3-XYLANASE
(Vibrio
sp.
AX-4) 		3 / 3 VAL A 155
VAL A 117
GLN A 168
 None
 0.72A 5qguA-2ddxA:
undetectable		 5qguA-2ddxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2ddx BETA-1,3-XYLANASE
(Vibrio
sp.
AX-4) 		3 / 3 VAL A 155
VAL A 117
GLN A 168
 None
 0.71A 5qgvA-2ddxA:
undetectable		 5qgvA-2ddxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2ddx BETA-1,3-XYLANASE
(Vibrio
sp.
AX-4) 		3 / 3 VAL A 155
VAL A 117
GLN A 168
 None
 0.72A 5qgwA-2ddxA:
undetectable		 5qgwA-2ddxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2ddx BETA-1,3-XYLANASE
(Vibrio
sp.
AX-4) 		3 / 3 VAL A 155
VAL A 117
GLN A 168
 None
 0.71A 5qgxA-2ddxA:
undetectable		 5qgxA-2ddxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2ddx BETA-1,3-XYLANASE
(Vibrio
sp.
AX-4) 		3 / 3 VAL A 155
VAL A 117
GLN A 168
 None
 0.71A 5qhfA-2ddxA:
undetectable		 5qhfA-2ddxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 2ddx BETA-1,3-XYLANASE
(Vibrio
sp.
AX-4) 		5 / 10 LEU A  64
ASN A  23
LEU A  29
ALA A  26
GLU A  63
 None
 1.26A 5y7pG-2ddxA:
undetectable		 5y7pG-2ddxA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 2ddx BETA-1,3-XYLANASE
(Vibrio
sp.
AX-4) 		5 / 12 VAL A 152
ILE A 149
LEU A  73
TYR A 105
VAL A  77
 None
 1.22A 6ajiA-2ddxA:
undetectable		 6ajiA-2ddxA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2ddx BETA-1,3-XYLANASE
(Vibrio
sp.
AX-4) 		4 / 6 LEU A 297
TYR A 267
ASP A 289
GLN A 275
 None
 1.47A 6djzC-2ddxA:
undetectable		 6djzC-2ddxA:
20.06