SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ddz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 2ddz 190AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 GLU A 166
ALA A 171
LEU A  95
VAL A 173
LEU A  91
VAL A  69
 None
 1.48A 1sn5B-2ddzA:
undetectable
1sn5D-2ddzA:
undetectable		 1sn5B-2ddzA:
17.14
1sn5D-2ddzA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 2ddz 190AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 LEU A  87
LEU A 172
MET A   4
 None
 0.82A 1ya3B-2ddzA:
undetectable		 1ya3B-2ddzA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2ddz 190AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 LEU A 154
ILE A 113
SER A 121
GLY A 137
 None
 1.02A 2otfA-2ddzA:
undetectable		 2otfA-2ddzA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 2ddz 190AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 LEU A 120
GLY A 137
ILE A  92
ILE A 113
 None
 0.70A 2q9rA-2ddzA:
undetectable		 2q9rA-2ddzA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2ddz 190AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A 104
ILE A 122
VAL A 145
THR A 142
LEU A 154
 None
 1.17A 2qo5A-2ddzA:
undetectable		 2qo5A-2ddzA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2ddz 190AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ARG A  12
GLU A  11
SER A 168
 GAI  A 514 (-3.9A)
None
None
 0.91A 2xctD-2ddzA:
3.8		 2xctD-2ddzA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 2ddz 190AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 ASN A 139
ILE A 152
GLY A 117
VAL A  96
ILE A 113
 None
 0.94A 3lzvB-2ddzA:
undetectable		 3lzvB-2ddzA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2ddz 190AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A  26
PHE A  76
ILE A 132
PRO A  79
LEU A  73
 None
None
None
GAI  A 510 ( 4.8A)
None
 1.15A 3nrrA-2ddzA:
undetectable		 3nrrA-2ddzA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2ddz 190AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A  26
PHE A  76
ILE A 132
PRO A  79
LEU A  73
 None
None
None
GAI  A 510 ( 4.8A)
None
 1.12A 3nrrB-2ddzA:
undetectable		 3nrrB-2ddzA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2ddz 190AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 GLU A 156
THR A 142
LEU A 138
VAL A 145
 None
 0.90A 4iizB-2ddzA:
undetectable		 4iizB-2ddzA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 2ddz 190AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 LEU A 138
ASP A  67
ILE A 104
 None
 0.65A 4xi3D-2ddzA:
undetectable		 4xi3D-2ddzA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 2ddz 190AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 ILE A 136
VAL A  69
ILE A   8
GLU A 163
 None
 0.76A 5og9A-2ddzA:
undetectable		 5og9A-2ddzA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2ddz 190AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 169
PHE A 164
LEU A  37
GLY A 137
LEU A  99
 None
 1.13A 5x24A-2ddzA:
undetectable		 5x24A-2ddzA:
19.47