SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2def'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 2def PEPTIDE DEFORMYLASE
(Escherichia
coli) 		4 / 7 VAL A  16
VAL A 138
GLY A 139
ARG A  56
 None
 0.96A 3bjwC-2defA:
undetectable		 3bjwC-2defA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 2def PEPTIDE DEFORMYLASE
(Escherichia
coli) 		5 / 10 VAL A 100
ILE A 130
ASP A 135
ILE A  44
ILE A  86
 None
 1.27A 3clbD-2defA:
undetectable		 3clbD-2defA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_F_ACTF701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2def PEPTIDE DEFORMYLASE
(Escherichia
coli) 		4 / 4 PHE A 142
HIS A 136
GLY A  89
ILE A  93
 NI  A 148 ( 4.6A)
NI  A 148 ( 3.2A)
None
None
 0.86A 4k50E-2defA:
0.0		 4k50E-2defA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_M_ACTM503_0
(RNA POLYMERASE
3D-POL)		 2def PEPTIDE DEFORMYLASE
(Escherichia
coli) 		4 / 4 PHE A 142
HIS A 136
GLY A  89
ILE A  93
 NI  A 148 ( 4.6A)
NI  A 148 ( 3.2A)
None
None
 0.90A 4k50M-2defA:
0.0		 4k50M-2defA:
15.16