SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dej'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A 111
TYR A  70
ALA A 133
GLU A 137
 None
APW  A 402 (-3.8A)
None
APW  A 402 ( 4.8A)
 0.86A 1dmaB-2dejA:
undetectable		 1dmaB-2dejA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 109
GLY A 146
SER A  81
GLY A  73
ILE A  74
 None
GLA  A 401 (-3.4A)
None
None
None
 1.11A 1q8jB-2dejA:
undetectable		 1q8jB-2dejA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A 213
ILE A 211
VAL A 220
SER A 208
 None
 1.03A 1rs7B-2dejA:
undetectable		 1rs7B-2dejA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 162
ASP A 149
LEU A 148
PHE A 151
 None
GLA  A 401 (-3.1A)
GLA  A 401 ( 4.3A)
None
 0.87A 1rtsB-2dejA:
undetectable		 1rtsB-2dejA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 139
GLU A 109
LEU A  78
 None
 0.78A 1v8bB-2dejA:
undetectable		 1v8bB-2dejA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 SER A   6
ASP A 149
CYH A 145
 None
GLA  A 401 (-3.1A)
GLA  A 401 (-4.6A)
 1.07A 2br4E-2dejA:
undetectable		 2br4E-2dejA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 7 SER A 105
ARG A   9
GLN A 150
GLU A 109
 APW  A 402 (-2.2A)
GLA  A 401 (-4.1A)
None
None
 1.08A 2c8aA-2dejA:
undetectable		 2c8aA-2dejA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 162
ASP A 149
LEU A 148
PHE A 151
 None
GLA  A 401 (-3.1A)
GLA  A 401 ( 4.3A)
None
 0.93A 2tsrB-2dejA:
undetectable		 2tsrB-2dejA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A  88
GLY A  87
LEU A  58
PHE A  75
 None
 0.72A 2vctA-2dejA:
undetectable		 2vctA-2dejA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A  88
GLY A  87
LEU A  58
PHE A  75
 None
 0.68A 2vctB-2dejA:
undetectable		 2vctB-2dejA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A  88
GLY A  87
LEU A  58
PHE A  75
 None
 0.68A 2vctC-2dejA:
undetectable		 2vctC-2dejA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		5 / 7 LEU A 283
ALA A 303
GLY A 302
ARG A   9
PHE A 286
 None
GLA  A 401 (-3.7A)
GLA  A 401 ( 4.1A)
GLA  A 401 (-4.1A)
None
 1.30A 2wq5A-2dejA:
undetectable		 2wq5A-2dejA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 8 VAL A 278
ASP A 284
GLY A 306
HIS A 269
 None
 1.01A 3af0A-2dejA:
undetectable		 3af0A-2dejA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 137
LEU A 300
SER A 105
GLY A 146
LEU A 148
 APW  A 402 ( 4.8A)
None
APW  A 402 (-2.2A)
GLA  A 401 (-3.4A)
GLA  A 401 ( 4.3A)
 1.21A 3j6pB-2dejA:
undetectable		 3j6pB-2dejA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REQ_A_ADNA801_1
(METHYLMALONYL-COA
MUTASE)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 4 TYR A  19
TYR A 238
GLU A 242
GLY A  14
 GLA  A 401 ( 4.9A)
None
None
None
 1.47A 3reqA-2dejA:
undetectable		 3reqA-2dejA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A 111
TYR A  70
ALA A 133
GLU A 137
 None
APW  A 402 (-3.8A)
None
APW  A 402 ( 4.8A)
 0.82A 4hyfA-2dejA:
undetectable		 4hyfA-2dejA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 8 GLY A 111
TYR A  70
ALA A 133
GLU A 137
 None
APW  A 402 (-3.8A)
None
APW  A 402 ( 4.8A)
 0.80A 4hyfB-2dejA:
undetectable		 4hyfB-2dejA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 8 GLY A 111
TYR A  70
ALA A 133
GLU A 137
 None
APW  A 402 (-3.8A)
None
APW  A 402 ( 4.8A)
 0.83A 4hyfC-2dejA:
undetectable		 4hyfC-2dejA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 8 THR A 115
GLY A  87
GLY A  86
VAL A  85
 None
 0.76A 4qvvK-2dejA:
undetectable
4qvvL-2dejA:
undetectable		 4qvvK-2dejA:
23.46
4qvvL-2dejA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 8 THR A 115
GLY A  87
GLY A  86
VAL A  85
 None
 0.76A 4qvvY-2dejA:
undetectable
4qvvZ-2dejA:
undetectable		 4qvvY-2dejA:
23.46
4qvvZ-2dejA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 8 TYR A  70
ASP A 149
VAL A 141
GLY A 142
 APW  A 402 (-3.8A)
GLA  A 401 (-3.1A)
None
None
 1.03A 5nzyA-2dejA:
undetectable		 5nzyA-2dejA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 348
VAL A 154
GLN A 150
 None
 0.65A 5qgjA-2dejA:
undetectable		 5qgjA-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 348
VAL A 154
GLN A 150
 None
 0.68A 5qglA-2dejA:
undetectable		 5qglA-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 348
VAL A 154
GLN A 150
 None
 0.67A 5qgmA-2dejA:
undetectable		 5qgmA-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 348
VAL A 154
GLN A 150
 None
 0.62A 5qgnA-2dejA:
undetectable		 5qgnA-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 348
VAL A 154
GLN A 150
 None
 0.72A 5qguA-2dejA:
undetectable		 5qguA-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 348
VAL A 154
GLN A 150
 None
 0.70A 5qgvA-2dejA:
undetectable		 5qgvA-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 348
VAL A 154
GLN A 150
 None
 0.72A 5qgwA-2dejA:
undetectable		 5qgwA-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 348
VAL A 154
GLN A 150
 None
 0.70A 5qgxA-2dejA:
undetectable		 5qgxA-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 348
VAL A 154
GLN A 150
 None
 0.70A 5qh1A-2dejA:
undetectable		 5qh1A-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH4_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 348
VAL A 154
GLN A 150
 None
 0.69A 5qh4A-2dejA:
undetectable		 5qh4A-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 348
VAL A 154
GLN A 150
 None
 0.63A 5qh5A-2dejA:
undetectable		 5qh5A-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 348
VAL A 154
GLN A 150
 None
 0.68A 5qh7A-2dejA:
undetectable		 5qh7A-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 348
VAL A 154
GLN A 150
 None
 0.69A 5qh9A-2dejA:
undetectable		 5qh9A-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 348
VAL A 154
GLN A 150
 None
 0.70A 5qhcA-2dejA:
undetectable		 5qhcA-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 348
VAL A 154
GLN A 150
 None
 0.71A 5qheA-2dejA:
undetectable		 5qheA-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 348
VAL A 154
GLN A 150
 None
 0.70A 5qhfA-2dejA:
undetectable		 5qhfA-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 348
VAL A 154
GLN A 150
 None
 0.63A 5qhgA-2dejA:
undetectable		 5qhgA-2dejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 295
GLY A 262
ILE A  13
GLU A  15
LEU A 272
 None
None
None
GLA  A 401 (-3.5A)
None
 1.12A 5ul4A-2dejA:
undetectable		 5ul4A-2dejA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A   2
ILE A  35
THR A  33
TYR A  32
 None
None
APW  A 402 ( 4.4A)
None
 0.78A 6cduG-2dejA:
undetectable
6cduH-2dejA:
2.0		 6cduG-2dejA:
22.88
6cduH-2dejA:
22.88