SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2deo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 THR A  62
PRO A  63
GLY A  64
THR A  34
 None
 0.88A 1oc3A-2deoA:
undetectable		 1oc3A-2deoA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 LEU A  60
ALA A  67
ALA A  98
VAL A  88
PHE A  41
 None
 1.18A 1rlbE-2deoA:
undetectable		 1rlbE-2deoA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 TYR A  25
ILE A  56
ILE A  82
ASP A  51
 None
 0.85A 1upfB-2deoA:
undetectable		 1upfB-2deoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 8 LEU A 150
ALA A 161
ILE A 165
GLY A 118
ILE A 117
 None
 1.46A 2o4nB-2deoA:
undetectable		 2o4nB-2deoA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ILE A  58
ILE A  73
LEU A 212
 None
 0.58A 2prgA-2deoA:
undetectable		 2prgA-2deoA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 PHE A 143
ALA A 119
ALA A  96
THR A  62
MET A  70
 None
 1.19A 2x2nA-2deoA:
undetectable		 2x2nA-2deoA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A  24
ALA A  48
ILE A  45
ILE A  86
ILE A  57
 None
 1.03A 3clbC-2deoA:
undetectable		 3clbC-2deoA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 VAL A  24
ALA A  48
ILE A  45
ILE A  86
ILE A  57
 None
 1.10A 3clbD-2deoA:
undetectable		 3clbD-2deoA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 VAL A  24
ALA A  48
ILE A  45
ILE A  86
ILE A  57
 None
 1.12A 3hbbA-2deoA:
undetectable		 3hbbA-2deoA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 VAL A  24
ALA A  48
ILE A  45
ILE A  86
ILE A  57
 None
 1.02A 3hbbC-2deoA:
undetectable		 3hbbC-2deoA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 VAL A  24
ALA A  48
ILE A  45
ILE A  86
ILE A  57
 None
 1.09A 3hbbD-2deoA:
undetectable		 3hbbD-2deoA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 8 LEU A 150
GLY A 118
ALA A  96
THR A  62
ILE A  33
 None
 1.41A 3jusB-2deoA:
undetectable		 3jusB-2deoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 LEU A 150
GLY A 118
ALA A  96
THR A  62
ILE A  33
 None
 1.41A 3jusB-2deoA:
undetectable		 3jusB-2deoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 7 ILE A 189
LEU A 193
LEU A 212
VAL A 205
SER A  80
 None
 1.48A 3r9vA-2deoA:
undetectable
3r9vB-2deoA:
undetectable		 3r9vA-2deoA:
22.15
3r9vB-2deoA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A 117
THR A 100
PHE A 164
LEU A 177
GLU A 183
 None
 1.42A 5l8oB-2deoA:
undetectable		 5l8oB-2deoA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 ALA A  96
ILE A 102
ALA A 103
LEU A  60
 None
 0.83A 5te8B-2deoA:
undetectable		 5te8B-2deoA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A  93
PRO A  63
GLY A  31
LYS A  30
ALA A 112
 None
 1.34A 5zvgA-2deoA:
undetectable		 5zvgA-2deoA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A  93
PRO A  63
GLY A  31
LYS A  30
ALA A 112
 None
 1.34A 5zvgB-2deoA:
undetectable		 5zvgB-2deoA:
16.92