SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dep'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 2dep THERMOSTABLE
CELLOXYLANASE
([Clostridium]
stercorarium) 		3 / 3 VAL A 124
VAL A 186
TRP A 200
 None
 0.94A 1av2C-2depA:
undetectable
1av2D-2depA:
undetectable		 1av2C-2depA:
9.30
1av2D-2depA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dep THERMOSTABLE
CELLOXYLANASE
([Clostridium]
stercorarium) 		3 / 3 GLN A 324
ILE A 279
HIS A 261
 None
 0.72A 1fm9A-2depA:
undetectable		 1fm9A-2depA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dep THERMOSTABLE
CELLOXYLANASE
([Clostridium]
stercorarium) 		3 / 3 GLN A 324
ILE A 279
HIS A 261
 None
 0.69A 1k74A-2depA:
undetectable		 1k74A-2depA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 2dep THERMOSTABLE
CELLOXYLANASE
([Clostridium]
stercorarium) 		4 / 4 VAL A  78
ALA A  59
LEU A 364
PHE A 342
 None
 0.89A 1q97B-2depA:
undetectable		 1q97B-2depA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 2dep THERMOSTABLE
CELLOXYLANASE
([Clostridium]
stercorarium) 		3 / 3 VAL A 124
VAL A 186
TRP A 200
 None
 0.96A 1w5uC-2depA:
undetectable
1w5uD-2depA:
undetectable		 1w5uC-2depA:
9.30
1w5uD-2depA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 2dep THERMOSTABLE
CELLOXYLANASE
([Clostridium]
stercorarium) 		5 / 12 LEU A  47
ILE A  57
PHE A  51
ASP A 328
PHE A 342
 None
 1.16A 1zz1B-2depA:
undetectable
1zz1C-2depA:
undetectable		 1zz1B-2depA:
22.22
1zz1C-2depA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 2dep THERMOSTABLE
CELLOXYLANASE
([Clostridium]
stercorarium) 		3 / 3 VAL A 186
TRP A 200
VAL A 124
 None
 0.91A 2izqA-2depA:
undetectable
2izqB-2depA:
undetectable		 2izqA-2depA:
9.30
2izqB-2depA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 2dep THERMOSTABLE
CELLOXYLANASE
([Clostridium]
stercorarium) 		4 / 7 LEU A  81
PHE A 110
ILE A  70
GLY A  58
 None
 0.88A 2v0mC-2depA:
undetectable		 2v0mC-2depA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 2dep THERMOSTABLE
CELLOXYLANASE
([Clostridium]
stercorarium) 		5 / 12 ASN A 164
GLN A 160
LEU A 159
THR A 204
ARG A 167
 None
 1.17A 3fsuA-2depA:
11.6		 3fsuA-2depA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 2dep THERMOSTABLE
CELLOXYLANASE
([Clostridium]
stercorarium) 		3 / 3 VAL A 124
VAL A 186
TRP A 200
 None
 0.86A 3l8lA-2depA:
undetectable
3l8lB-2depA:
undetectable		 3l8lA-2depA:
9.30
3l8lB-2depA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 2dep THERMOSTABLE
CELLOXYLANASE
([Clostridium]
stercorarium) 		3 / 3 GLU A  72
GLU A 113
ASN A 114
 None
 0.91A 3lp9B-2depA:
undetectable
3lp9D-2depA:
undetectable		 3lp9B-2depA:
20.06
3lp9D-2depA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 2dep THERMOSTABLE
CELLOXYLANASE
([Clostridium]
stercorarium) 		4 / 8 LEU A 287
ASN A 289
LEU A 242
ILE A 275
 None
 0.88A 4ok1A-2depA:
undetectable		 4ok1A-2depA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 2dep THERMOSTABLE
CELLOXYLANASE
([Clostridium]
stercorarium) 		3 / 3 SER A 350
ASP A 347
GLN A 319
 None
 0.75A 4oltA-2depA:
undetectable
4oltB-2depA:
undetectable		 4oltA-2depA:
21.47
4oltB-2depA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 2dep THERMOSTABLE
CELLOXYLANASE
([Clostridium]
stercorarium) 		3 / 3 GLN A 319
SER A 350
ASP A 347
 None
 0.71A 4qwpA-2depA:
undetectable
4qwpB-2depA:
undetectable		 4qwpA-2depA:
21.02
4qwpB-2depA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 2dep THERMOSTABLE
CELLOXYLANASE
([Clostridium]
stercorarium) 		4 / 5 ASP A 230
VAL A 246
PHE A 282
GLY A 258
 None
 1.06A 4xp6A-2depA:
undetectable		 4xp6A-2depA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dep THERMOSTABLE
CELLOXYLANASE
([Clostridium]
stercorarium) 		3 / 3 GLN A 324
ILE A 279
HIS A 261
 None
 0.69A 5z12B-2depA:
undetectable		 5z12B-2depA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 2dep THERMOSTABLE
CELLOXYLANASE
([Clostridium]
stercorarium) 		4 / 7 VAL A 186
LEU A 135
PHE A 133
LEU A 158
 None
 1.20A 6aycA-2depA:
undetectable		 6aycA-2depA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2dep THERMOSTABLE
CELLOXYLANASE
([Clostridium]
stercorarium) 		5 / 7 ALA A 375
PHE A  55
ILE A  57
PHE A 366
LEU A  47
 None
 1.50A 6b5vA-2depA:
undetectable
6b5vB-2depA:
undetectable		 6b5vA-2depA:
12.07
6b5vB-2depA:
12.07