SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2det'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		4 / 8 THR A 189
SER A  18
ALA A  22
ILE A  67
 None
SO4  A5001 (-2.7A)
None
None
 0.79A 1c9sI-2detA:
undetectable
1c9sJ-2detA:
undetectable		 1c9sI-2detA:
11.89
1c9sJ-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 10 ALA A  22
ILE A  67
GLY A  14
THR A 189
SER A  18
 None
None
SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
 0.94A 1c9sN-2detA:
undetectable
1c9sO-2detA:
undetectable		 1c9sN-2detA:
11.89
1c9sO-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 11 ALA A  22
ILE A  67
GLY A  14
THR A 189
SER A  18
 None
None
SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
 0.96A 1c9sP-2detA:
undetectable
1c9sQ-2detA:
undetectable		 1c9sP-2detA:
11.89
1c9sQ-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 9 ALA A  22
ILE A  67
GLY A  14
THR A 189
SER A  18
 None
None
SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
 0.94A 1c9sQ-2detA:
undetectable
1c9sR-2detA:
undetectable		 1c9sQ-2detA:
11.89
1c9sR-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 10 GLY A  14
THR A 189
SER A  18
ALA A  22
ILE A  67
 SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
None
None
 0.95A 1c9sL-2detA:
undetectable
1c9sV-2detA:
undetectable		 1c9sL-2detA:
11.89
1c9sV-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		4 / 8 LEU A 167
ALA A 125
VAL A  10
VAL A  32
 None
 0.79A 1epbB-2detA:
undetectable		 1epbB-2detA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 9 GLY A  14
THR A 189
SER A  18
ALA A  22
ILE A  67
 SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
None
None
 0.92A 1gtfD-2detA:
undetectable
1gtfE-2detA:
undetectable		 1gtfD-2detA:
11.89
1gtfE-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 10 GLY A  14
THR A 189
SER A  18
ALA A  22
ILE A  67
 SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
None
None
 0.91A 1gtfJ-2detA:
undetectable
1gtfK-2detA:
undetectable		 1gtfJ-2detA:
11.89
1gtfK-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 11 ALA A  22
ILE A  67
GLY A  14
THR A 189
SER A  18
 None
None
SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
 0.95A 1gtfQ-2detA:
undetectable
1gtfR-2detA:
undetectable		 1gtfQ-2detA:
11.89
1gtfR-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 9 ALA A  22
ILE A  67
GLY A  14
THR A 189
SER A  18
 None
None
SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
 0.95A 1gtfR-2detA:
undetectable
1gtfS-2detA:
undetectable		 1gtfR-2detA:
11.89
1gtfS-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 11 ALA A  22
ILE A  67
GLY A  14
THR A 189
SER A  18
 None
None
SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
 0.94A 1gtfS-2detA:
undetectable
1gtfT-2detA:
undetectable		 1gtfS-2detA:
11.89
1gtfT-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		4 / 7 ALA A  22
ILE A  67
THR A 189
SER A  18
 None
None
None
SO4  A5001 (-2.7A)
 0.76A 1gtnA-2detA:
undetectable
1gtnK-2detA:
undetectable		 1gtnA-2detA:
11.89
1gtnK-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		4 / 8 THR A 189
SER A  18
ALA A  22
ILE A  67
 None
SO4  A5001 (-2.7A)
None
None
 0.76A 1gtnA-2detA:
undetectable
1gtnB-2detA:
undetectable		 1gtnA-2detA:
11.89
1gtnB-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		4 / 8 THR A 189
SER A  18
ALA A  22
ILE A  67
 None
SO4  A5001 (-2.7A)
None
None
 0.74A 1gtnE-2detA:
undetectable
1gtnF-2detA:
undetectable		 1gtnE-2detA:
11.89
1gtnF-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		4 / 8 THR A 189
SER A  18
ALA A  22
ILE A  67
 None
SO4  A5001 (-2.7A)
None
None
 0.75A 1gtnI-2detA:
undetectable
1gtnJ-2detA:
undetectable		 1gtnI-2detA:
11.89
1gtnJ-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 11 ALA A  22
ILE A  67
GLY A  14
THR A 189
SER A  18
 None
None
SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
 1.00A 1gtnT-2detA:
undetectable
1gtnU-2detA:
undetectable		 1gtnT-2detA:
11.89
1gtnU-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 12 GLY A  14
THR A 189
SER A  18
ALA A  22
ILE A  67
 SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
None
None
 1.00A 1gtnL-2detA:
undetectable
1gtnV-2detA:
undetectable		 1gtnL-2detA:
11.89
1gtnV-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		4 / 6 GLN A  28
VAL A  32
ALA A  22
SER A  21
 None
 1.01A 1p6kA-2detA:
undetectable		 1p6kA-2detA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 10 TYR A 153
LEU A 287
VAL A 331
PHE A 333
VAL A 340
 U  C  35 ( 4.7A)
None
None
None
None
 1.37A 1q23E-2detA:
undetectable		 1q23E-2detA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		3 / 3 TRP A  40
PHE A  83
TRP A  79
 None
 1.25A 1r15C-2detA:
undetectable		 1r15C-2detA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		3 / 3 TRP A  40
PHE A  83
TRP A  79
 None
 1.23A 1r15F-2detA:
2.0		 1r15F-2detA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		3 / 3 TRP A  40
PHE A  83
TRP A  79
 None
 1.24A 1r15G-2detA:
2.0		 1r15G-2detA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		3 / 3 TRP A  40
PHE A  83
TRP A  79
 None
 1.23A 1r15H-2detA:
undetectable		 1r15H-2detA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		4 / 8 ALA A  22
ILE A  67
THR A 189
SER A  18
 None
None
None
SO4  A5001 (-2.7A)
 0.79A 1utdB-2detA:
undetectable
1utdC-2detA:
undetectable		 1utdB-2detA:
11.89
1utdC-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 10 ALA A  22
ILE A  67
GLY A  14
THR A 189
SER A  18
 None
None
SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
 0.94A 1utdE-2detA:
undetectable
1utdF-2detA:
undetectable		 1utdE-2detA:
11.89
1utdF-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		4 / 8 ALA A  22
ILE A  67
THR A 189
SER A  18
 None
None
None
SO4  A5001 (-2.7A)
 0.79A 1utdF-2detA:
undetectable
1utdG-2detA:
undetectable		 1utdF-2detA:
11.89
1utdG-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 10 ALA A  22
ILE A  67
GLY A  14
THR A 189
SER A  18
 None
None
SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
 0.94A 1utdH-2detA:
undetectable
1utdI-2detA:
undetectable		 1utdH-2detA:
11.89
1utdI-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		4 / 8 ALA A  22
ILE A  67
THR A 189
SER A  18
 None
None
None
SO4  A5001 (-2.7A)
 0.79A 1utdI-2detA:
undetectable
1utdJ-2detA:
undetectable		 1utdI-2detA:
11.89
1utdJ-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 12 ALA A  22
ILE A  67
GLY A  14
THR A 189
SER A  18
 None
None
SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
 0.93A 1utdL-2detA:
undetectable
1utdM-2detA:
undetectable		 1utdL-2detA:
11.89
1utdM-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 12 ALA A  22
ILE A  67
GLY A  14
THR A 189
SER A  18
 None
None
SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
 0.93A 1utdO-2detA:
undetectable
1utdP-2detA:
undetectable		 1utdO-2detA:
11.89
1utdP-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 11 ALA A  22
ILE A  67
GLY A  14
THR A 189
SER A  18
 None
None
SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
 0.94A 1utdP-2detA:
undetectable
1utdQ-2detA:
undetectable		 1utdP-2detA:
11.89
1utdQ-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 11 ALA A  22
ILE A  67
GLY A  14
THR A 189
SER A  18
 None
None
SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
 0.96A 1utdS-2detA:
undetectable
1utdT-2detA:
undetectable		 1utdS-2detA:
11.89
1utdT-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 10 ALA A  22
ILE A  67
GLY A  14
THR A 189
SER A  18
 None
None
SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
 0.97A 1utdU-2detA:
undetectable
1utdV-2detA:
undetectable		 1utdU-2detA:
11.89
1utdV-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 11 GLY A  14
THR A 189
SER A  18
ALA A  22
ILE A  67
 SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
None
None
 0.95A 1utdL-2detA:
undetectable
1utdV-2detA:
undetectable		 1utdL-2detA:
11.89
1utdV-2detA:
11.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		7 / 11 GLY A  11
SER A  13
ASP A  99
THR A 126
GLY A 127
GLN A 151
PHE A 154
 None
SO4  A5001 (-3.1A)
U  C  35 ( 3.5A)
None
SO4  A5001 ( 3.8A)
U  C  34 ( 4.4A)
U  C  34 ( 3.7A)
 1.00A 2hmaA-2detA:
45.3		 2hmaA-2detA:
57.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		10 / 11 GLY A  11
SER A  18
ASP A  99
ASN A 103
LYS A 107
THR A 126
GLY A 127
HIS A 128
GLN A 151
PHE A 154
 None
SO4  A5001 (-2.7A)
U  C  35 ( 3.5A)
U  C  34 ( 3.1A)
U  C  34 ( 3.0A)
None
SO4  A5001 ( 3.8A)
U  C  34 ( 3.6A)
U  C  34 ( 4.4A)
U  C  34 ( 3.7A)
 0.71A 2hmaA-2detA:
45.3		 2hmaA-2detA:
57.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		4 / 7 SER A  21
ARG A 131
PHE A 168
PHE A 108
 None
 1.16A 2q6hA-2detA:
undetectable		 2q6hA-2detA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		4 / 7 ILE A 329
PHE A 300
ARG A 305
THR A 307
 None
 1.21A 2zxwN-2detA:
0.0
2zxwW-2detA:
undetectable		 2zxwN-2detA:
21.21
2zxwW-2detA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		3 / 3 GLU A 352
LEU A 142
LEU A 173
 None
 0.72A 3ohtA-2detA:
undetectable		 3ohtA-2detA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		3 / 3 GLU A 352
LEU A 142
LEU A 173
 None
 0.73A 3ohtB-2detA:
undetectable		 3ohtB-2detA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 12 ALA A 125
GLY A  11
GLY A 127
SER A  18
MET A  12
 None
None
SO4  A5001 ( 3.8A)
SO4  A5001 (-2.7A)
None
 1.18A 3ou7A-2detA:
undetectable		 3ou7A-2detA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 12 ALA A 125
GLY A  11
GLY A 127
SER A  18
MET A  12
 None
None
SO4  A5001 ( 3.8A)
SO4  A5001 (-2.7A)
None
 1.19A 3ou7D-2detA:
undetectable		 3ou7D-2detA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 10 LEU A 364
ILE A 288
ALA A 289
VAL A 340
VAL A 337
 None
 0.88A 3r9cA-2detA:
undetectable		 3r9cA-2detA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 12 LEU A 185
GLY A  14
GLY A  15
VAL A  61
GLY A  11
 None
SO4  A5001 (-4.0A)
SO4  A5001 (-3.2A)
None
None
 0.98A 3uq6A-2detA:
undetectable		 3uq6A-2detA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		3 / 3 TYR A 123
ARG A 132
SER A 166
 None
 1.10A 4dr2I-2detA:
undetectable
4dr2J-2detA:
undetectable		 4dr2I-2detA:
15.18
4dr2J-2detA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 9 ALA A  58
LEU A  35
GLY A  34
LEU A  69
LEU A  55
 None
 1.19A 5dqfA-2detA:
undetectable		 5dqfA-2detA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 10 GLY A  14
THR A 189
SER A  18
ALA A  22
ILE A  67
 SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
None
None
 0.92A 5eevA-2detA:
undetectable
5eevB-2detA:
undetectable		 5eevA-2detA:
11.89
5eevB-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 10 GLY A  14
THR A 189
SER A  18
ALA A  22
ILE A  67
 SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
None
None
 0.91A 5eewA-2detA:
undetectable
5eewB-2detA:
undetectable		 5eewA-2detA:
11.89
5eewB-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 10 GLY A  14
THR A 189
SER A  18
ALA A  22
ILE A  67
 SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
None
None
 0.91A 5eexA-2detA:
undetectable
5eexB-2detA:
undetectable		 5eexA-2detA:
11.89
5eexB-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 10 GLY A  14
THR A 189
SER A  18
ALA A  22
ILE A  67
 SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
None
None
 0.91A 5eeyA-2detA:
undetectable
5eeyB-2detA:
undetectable		 5eeyA-2detA:
11.89
5eeyB-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 10 GLY A  14
THR A 189
SER A  18
ALA A  22
ILE A  67
 SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
None
None
 0.91A 5eezA-2detA:
undetectable
5eezB-2detA:
undetectable		 5eezA-2detA:
11.89
5eezB-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 10 GLY A  14
THR A 189
SER A  18
ALA A  22
ILE A  67
 SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
None
None
 0.92A 5ef0A-2detA:
undetectable
5ef0B-2detA:
undetectable		 5ef0A-2detA:
11.89
5ef0B-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 10 GLY A  14
THR A 189
SER A  18
ALA A  22
ILE A  67
 SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
None
None
 0.91A 5ef1A-2detA:
undetectable
5ef1B-2detA:
undetectable		 5ef1A-2detA:
11.89
5ef1B-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 10 GLY A  14
THR A 189
SER A  18
ALA A  22
ILE A  67
 SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
None
None
 0.92A 5ef2A-2detA:
undetectable
5ef2B-2detA:
undetectable		 5ef2A-2detA:
11.89
5ef2B-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 10 GLY A  14
THR A 189
SER A  18
ALA A  22
ILE A  67
 SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
None
None
 0.92A 5ef3A-2detA:
undetectable
5ef3B-2detA:
undetectable		 5ef3A-2detA:
11.89
5ef3B-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		5 / 12 LEU A  24
SER A  21
VAL A 178
ALA A 182
LEU A 187
 None
 1.12A 5ikrA-2detA:
undetectable		 5ikrA-2detA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		3 / 3 VAL A   8
TYR A  30
GLN A  31
 None
 0.73A 5qgrA-2detA:
undetectable		 5qgrA-2detA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		4 / 5 ILE A 329
PHE A 300
ARG A 305
THR A 307
 None
 1.29A 5z84N-2detA:
undetectable
5z84W-2detA:
undetectable		 5z84N-2detA:
21.21
5z84W-2detA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA
(Escherichia
coli) 		4 / 7 PHE A 206
GLY A  93
ALA A  92
LEU A 214
 C  C  36 ( 4.0A)
None
None
None
 0.81A 6dwnB-2detA:
undetectable		 6dwnB-2detA:
12.73