SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dfa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EVE_A_E20A2001_1
(ACETYLCHOLINESTERASE)		 2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195
(Thermus
thermophilus) 		5 / 10 GLY A  40
LEU A  98
PHE A  37
TYR A  89
HIS A  38
 None
 1.45A 1eveA-2dfaA:
1.9		 1eveA-2dfaA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195
(Thermus
thermophilus) 		4 / 6 GLU A 167
LEU A 220
VAL A 200
MET A 199
 None
 1.00A 1hk1A-2dfaA:
undetectable		 1hk1A-2dfaA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195
(Thermus
thermophilus) 		5 / 8 ASP A  21
GLY A  39
GLY A  40
ILE A  45
ALA A  31
 None
 1.13A 1sguA-2dfaA:
undetectable		 1sguA-2dfaA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195
(Thermus
thermophilus) 		4 / 5 LEU A 103
ALA A 100
LEU A  98
SER A  95
 None
 1.06A 1tt6B-2dfaA:
undetectable		 1tt6B-2dfaA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		 2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195
(Thermus
thermophilus) 		5 / 12 ASN A  32
HIS A 107
HIS A 106
VAL A 142
VAL A 161
 None
 1.30A 1zgfA-2dfaA:
undetectable		 1zgfA-2dfaA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195
(Thermus
thermophilus) 		4 / 7 ASP A  21
ALA A   9
ASP A   8
GLY A  39
 None
 0.93A 2fxdB-2dfaA:
undetectable		 2fxdB-2dfaA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195
(Thermus
thermophilus) 		5 / 12 ALA A  17
GLY A  10
GLU A  47
GLY A  43
LEU A  33
 None
 1.07A 2x1lB-2dfaA:
undetectable		 2x1lB-2dfaA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195
(Thermus
thermophilus) 		4 / 8 GLN A 175
LEU A 116
LYS A 117
LEU A 144
 None
 1.19A 2xn3A-2dfaA:
undetectable
2xn3B-2dfaA:
undetectable		 2xn3A-2dfaA:
23.94
2xn3B-2dfaA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195
(Thermus
thermophilus) 		5 / 8 LEU A 103
ALA A  52
GLY A  60
LEU A  33
GLY A  10
 None
 1.36A 2yfxA-2dfaA:
undetectable		 2yfxA-2dfaA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195
(Thermus
thermophilus) 		4 / 8 PRO A 189
ALA A 193
ALA A 196
GLU A 231
 None
 0.51A 3dtuC-2dfaA:
undetectable
3dtuD-2dfaA:
undetectable		 3dtuC-2dfaA:
19.52
3dtuD-2dfaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195
(Thermus
thermophilus) 		5 / 12 ILE A  45
GLN A  90
ALA A  61
LEU A  33
ILE A 128
 None
 0.89A 3ozwB-2dfaA:
undetectable		 3ozwB-2dfaA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195
(Thermus
thermophilus) 		5 / 12 ALA A 131
ALA A  61
ALA A  93
GLY A  92
LEU A  94
 None
 1.05A 4oaeA-2dfaA:
undetectable		 4oaeA-2dfaA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195
(Thermus
thermophilus) 		4 / 6 LEU A 141
LYS A 109
PRO A 110
GLU A 163
 None
 1.26A 4z4gA-2dfaA:
undetectable		 4z4gA-2dfaA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195
(Thermus
thermophilus) 		4 / 4 ALA A   9
PRO A  63
LEU A 141
HIS A 107
 None
 1.37A 5eskA-2dfaA:
undetectable		 5eskA-2dfaA:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195
(Thermus
thermophilus) 		5 / 12 LEU A  94
SER A  41
ARG A  44
GLY A  40
GLY A  10
 None
 1.06A 5o4yD-2dfaA:
undetectable
5o4yE-2dfaA:
undetectable		 5o4yD-2dfaA:
31.82
5o4yE-2dfaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195
(Thermus
thermophilus) 		3 / 3 ILE A  91
VAL A 108
PRO A 110
 None
 0.68A 5uunA-2dfaA:
undetectable		 5uunA-2dfaA:
22.64