SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 2dfe RIBONUCLEASE HII
(Thermococcus
kodakarensis) 		5 / 12 PHE A 114
LEU A 118
ALA A 104
VAL A 141
LEU A  80
 None
 0.94A 1cbsA-2dfeA:
undetectable		 1cbsA-2dfeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2dfe RIBONUCLEASE HII
(Thermococcus
kodakarensis) 		3 / 3 ARG A 177
VAL A 194
TRP A 198
 None
 1.14A 1qw6A-2dfeA:
undetectable		 1qw6A-2dfeA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2dfe RIBONUCLEASE HII
(Thermococcus
kodakarensis) 		3 / 3 ARG A 177
VAL A 194
TRP A 198
 None
 1.13A 1qwcA-2dfeA:
undetectable		 1qwcA-2dfeA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2dfe RIBONUCLEASE HII
(Thermococcus
kodakarensis) 		3 / 3 ARG A 177
VAL A 194
TRP A 198
 None
 1.14A 1vagA-2dfeA:
undetectable		 1vagA-2dfeA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2dfe RIBONUCLEASE HII
(Thermococcus
kodakarensis) 		4 / 5 ALA A 106
PHE A 114
ILE A   6
ASP A   7
 None
 1.02A 1yc2D-2dfeA:
undetectable		 1yc2D-2dfeA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2dfe RIBONUCLEASE HII
(Thermococcus
kodakarensis) 		3 / 3 ARG A 177
VAL A 194
TRP A 198
 None
 1.13A 1zviA-2dfeA:
undetectable		 1zviA-2dfeA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 2dfe RIBONUCLEASE HII
(Thermococcus
kodakarensis) 		5 / 12 PHE A 114
LEU A 118
ALA A 104
VAL A 141
LEU A  80
 None
 0.94A 2fr3A-2dfeA:
undetectable		 2fr3A-2dfeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2dfe RIBONUCLEASE HII
(Thermococcus
kodakarensis) 		3 / 3 VAL A  23
VAL A 141
ASP A 153
 None
 0.72A 2fumD-2dfeA:
undetectable		 2fumD-2dfeA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 2dfe RIBONUCLEASE HII
(Thermococcus
kodakarensis) 		5 / 12 PHE A 114
LEU A 118
ALA A 104
VAL A 141
LEU A  80
 None
 0.98A 2g78A-2dfeA:
undetectable		 2g78A-2dfeA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 2dfe RIBONUCLEASE HII
(Thermococcus
kodakarensis) 		4 / 6 ILE A  20
PRO A  99
LEU A 122
ILE A 102
 None
 0.96A 2q83B-2dfeA:
undetectable		 2q83B-2dfeA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 2dfe RIBONUCLEASE HII
(Thermococcus
kodakarensis) 		4 / 8 LEU A  52
ASN A  54
LEU A  57
ARG A 154
 None
 1.04A 2xn3A-2dfeA:
undetectable
2xn3B-2dfeA:
undetectable		 2xn3A-2dfeA:
21.04
2xn3B-2dfeA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 2dfe RIBONUCLEASE HII
(Thermococcus
kodakarensis) 		4 / 8 PHE A  53
ILE A  56
ALA A 148
THR A 151
 None
 0.86A 3me6B-2dfeA:
undetectable		 3me6B-2dfeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 2dfe RIBONUCLEASE HII
(Thermococcus
kodakarensis) 		4 / 7 ILE A  56
LEU A  60
ALA A  21
ALA A  22
 None
 0.87A 3r9tB-2dfeA:
undetectable		 3r9tB-2dfeA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2dfe RIBONUCLEASE HII
(Thermococcus
kodakarensis) 		4 / 7 LEU A  80
GLU A  84
PRO A  70
ILE A  73
 None
 0.76A 3s56B-2dfeA:
undetectable		 3s56B-2dfeA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)		 2dfe RIBONUCLEASE HII
(Thermococcus
kodakarensis) 		5 / 12 VAL A  38
SER A  41
ILE A 146
ARG A  49
VAL A  59
 None
 1.41A 4rujA-2dfeA:
undetectable		 4rujA-2dfeA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 2dfe RIBONUCLEASE HII
(Thermococcus
kodakarensis) 		3 / 3 PRO A  17
ARG A 152
GLU A  67
 None
 0.99A 5j6hA-2dfeA:
undetectable		 5j6hA-2dfeA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dfe RIBONUCLEASE HII
(Thermococcus
kodakarensis) 		4 / 4 LEU A  68
ARG A  11
ILE A  73
PHE A  83
 None
 1.27A 5kirB-2dfeA:
undetectable		 5kirB-2dfeA:
18.74