SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dfk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 2dfk COLLYBISTIN II
(Rattus
norvegicus) 		4 / 6 ASP A 314
THR A 346
GLU A 348
GLU A 345
 None
 1.20A 2dttB-2dfkA:
undetectable
2dttC-2dfkA:
undetectable		 2dttB-2dfkA:
15.00
2dttC-2dfkA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2dfk COLLYBISTIN II
(Rattus
norvegicus) 		4 / 7 ARG A 215
GLU A 126
ALA A 219
ALA A 220
 GOL  A 602 (-3.9A)
None
None
None
 1.08A 2ejfA-2dfkA:
undetectable		 2ejfA-2dfkA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 2dfk COLLYBISTIN II
(Rattus
norvegicus) 		4 / 6 ASP A 314
ILE A 313
LEU A 341
GLU A 370
 None
 1.01A 2ya7A-2dfkA:
undetectable		 2ya7A-2dfkA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 2dfk COLLYBISTIN II
(Rattus
norvegicus) 		4 / 6 ASP A 314
ILE A 313
LEU A 341
GLU A 370
 None
 1.00A 2ya7B-2dfkA:
undetectable		 2ya7B-2dfkA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 2dfk COLLYBISTIN II
(Rattus
norvegicus) 		4 / 6 ASP A 314
ILE A 313
LEU A 341
GLU A 370
 None
 1.01A 2ya7D-2dfkA:
undetectable		 2ya7D-2dfkA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2dfk COLLYBISTIN II
(Rattus
norvegicus) 		4 / 7 ASP A 213
ARG A  51
VAL A  54
ILE A  58
 None
 1.04A 2yfbA-2dfkA:
1.6		 2yfbA-2dfkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2dfk COLLYBISTIN II
(Rattus
norvegicus) 		4 / 6 ASP A 213
ARG A  51
VAL A  54
ILE A  58
 None
 1.12A 2yfbB-2dfkA:
3.0		 2yfbB-2dfkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 2dfk COLLYBISTIN II
(Rattus
norvegicus) 		4 / 7 CYH A 171
PHE A  96
PHE A 167
TYR A 164
 None
 1.31A 3hggA-2dfkA:
1.2		 3hggA-2dfkA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 2dfk COLLYBISTIN II
(Rattus
norvegicus) 		3 / 3 LYS A 340
VAL A 349
HIS A 342
 None
 1.03A 3tj7A-2dfkA:
undetectable		 3tj7A-2dfkA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2dfk COLLYBISTIN II
(Rattus
norvegicus) 		4 / 8 THR A 207
LEU A 221
VAL A 217
VAL A  54
 None
 1.10A 4l4dA-2dfkA:
undetectable		 4l4dA-2dfkA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2dfk COLLYBISTIN II
(Rattus
norvegicus) 		5 / 12 ASP A 291
HIS A 292
GLU A 265
ILE A 380
PHE A 382
 None
 1.41A 5igwA-2dfkA:
undetectable		 5igwA-2dfkA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2dfk COLLYBISTIN II
(Rattus
norvegicus) 		4 / 5 PRO A 278
GLY A 280
TYR A 279
VAL A 333
 None
 1.23A 5x80C-2dfkA:
1.1
5x80D-2dfkA:
1.2		 5x80C-2dfkA:
17.81
5x80D-2dfkA:
17.81