SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dfs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 2dfs MYOSIN-5A
(Gallus
gallus) 		4 / 5 LEU A  77
SER A  96
LEU A  98
GLY A  70
 None
 1.10A 1a4lB-2dfsA:
undetectable		 1a4lB-2dfsA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 2dfs MYOSIN-5A
(Gallus
gallus) 		3 / 3 VAL A  85
TRP A  22
TRP A  14
 None
 1.04A 1c4dA-2dfsA:
undetectable
1c4dB-2dfsA:
undetectable		 1c4dA-2dfsA:
1.59
1c4dB-2dfsA:
1.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 8 ILE A 226
VAL A 416
ASN A 420
ASN A 238
GLY A 434
 None
 1.33A 1dzmA-2dfsA:
undetectable		 1dzmA-2dfsA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_B_BZMB600_0
(ODORANT-BINDING
PROTEIN)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 9 ILE A 226
VAL A 416
ASN A 420
ASN A 238
GLY A 434
 None
 1.31A 1dzmB-2dfsA:
0.0		 1dzmB-2dfsA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 12 ILE A 139
TYR A 175
TYR A 119
HIS A 657
ILE A 124
 None
 0.95A 1fmlB-2dfsA:
undetectable		 1fmlB-2dfsA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 12 GLY A 236
ALA A 237
GLY A 434
ILE A 433
VAL A 196
 None
 0.90A 1k6cB-2dfsA:
undetectable		 1k6cB-2dfsA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2dfs MYOSIN-5A
(Gallus
gallus) 		3 / 3 THR A 655
GLU A 145
ASP A 134
 None
 0.86A 1nt2A-2dfsA:
undetectable		 1nt2A-2dfsA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 11 GLY A 236
ALA A 237
GLY A 434
ILE A 433
VAL A 196
 None
 0.80A 1t7jA-2dfsA:
undetectable		 1t7jA-2dfsA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2dfs MYOSIN-5A
(Gallus
gallus) 		3 / 3 ARG A 248
GLU A 450
GLN A 252
 None
 1.09A 2p16A-2dfsA:
undetectable		 2p16A-2dfsA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 2dfs MYOSIN-5A
(Gallus
gallus) 		4 / 6 ASP A 738
PHE A 751
TYR A 742
LEU A 759
 None
 1.16A 2w98A-2dfsA:
undetectable
2w98B-2dfsA:
undetectable		 2w98A-2dfsA:
14.77
2w98B-2dfsA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2dfs MYOSIN-5A
(Gallus
gallus) 		4 / 8 LEU A 592
ILE A 407
LEU A 411
LEU A 588
 None
 0.79A 2xfhA-2dfsA:
undetectable		 2xfhA-2dfsA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 2dfs MYOSIN-5A
(Gallus
gallus) 		3 / 3 PRO A  60
GLU A  49
TYR A  50
 None
 0.79A 2zmbA-2dfsA:
undetectable		 2zmbA-2dfsA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 12 GLY A 236
ALA A 237
GLY A 434
ILE A 433
VAL A 196
 None
 0.90A 3el4A-2dfsA:
undetectable		 3el4A-2dfsA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 12 GLY A 236
ALA A 237
GLY A 434
ILE A 433
VAL A 196
 None
 0.87A 3el5B-2dfsA:
undetectable		 3el5B-2dfsA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dfs MYOSIN-5A
(Gallus
gallus) 		3 / 3 ILE A 332
PHE A 360
HIS A 406
 None
 0.66A 3h0aA-2dfsA:
undetectable		 3h0aA-2dfsA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 12 ASN A 208
SER A 218
ASP A 437
ILE A 224
GLU A 225
 None
 1.42A 3jb3A-2dfsA:
undetectable		 3jb3A-2dfsA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 12 HIS A 468
GLN A 149
VAL A 142
ILE A 105
GLY A 104
 None
 1.11A 3kk6B-2dfsA:
undetectable		 3kk6B-2dfsA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dfs MYOSIN-5A
(Gallus
gallus) 		4 / 8 LEU A 651
LEU A 243
TYR A 242
ILE A 160
 None
 0.86A 3ln1A-2dfsA:
undetectable		 3ln1A-2dfsA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_2
(VITAMIN D3 RECEPTOR)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 9 PHE A 340
LEU A 333
LEU A 580
TYR A 408
VAL A 249
 None
 1.47A 3m7rA-2dfsA:
0.0		 3m7rA-2dfsA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 2dfs MYOSIN-5A
(Gallus
gallus) 		4 / 6 ILE A 159
ASP A 229
ILE A 235
VAL A 183
 None
 0.91A 3n3iA-2dfsA:
undetectable		 3n3iA-2dfsA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 2dfs MYOSIN-5A
(Gallus
gallus) 		4 / 5 ASN A 200
GLU A 121
THR A 182
SER A 199
 None
 0.99A 3p2kC-2dfsA:
undetectable		 3p2kC-2dfsA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2dfs MYOSIN-5A
(Gallus
gallus) 		3 / 3 GLY A 166
GLY A 168
THR A 170
 None
 0.40A 3si7B-2dfsA:
undetectable		 3si7B-2dfsA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 2dfs MYOSIN-5A
(Gallus
gallus) 		4 / 7 ILE A 487
LYS A 739
PHE A 750
GLY A 745
 None
 1.16A 3sj0X-2dfsA:
undetectable		 3sj0X-2dfsA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 2dfs MYOSIN-5A
(Gallus
gallus) 		6 / 12 ALA A 237
VAL A 196
ILE A 224
GLY A 434
ILE A 433
VAL A 192
 None
 1.16A 3so9B-2dfsA:
undetectable		 3so9B-2dfsA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 9 GLY A 236
ALA A 237
GLY A 434
ILE A 433
VAL A 196
 None
 0.92A 3u7sA-2dfsA:
undetectable		 3u7sA-2dfsA:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 9 GLY A 236
ALA A 237
GLY A 434
ILE A 433
VAL A 196
 None
 0.99A 3u7sB-2dfsA:
undetectable		 3u7sB-2dfsA:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2dfs MYOSIN-5A
(Gallus
gallus) 		3 / 3 ASP A 740
LYS A 739
ASP A 738
 None
 0.58A 4a7tA-2dfsA:
undetectable		 4a7tA-2dfsA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 2dfs MYOSIN-5A
(Gallus
gallus) 		4 / 5 GLU A 760
SER A  78
ARG A 710
PRO A  65
 None
 1.42A 4k17B-2dfsA:
undetectable		 4k17B-2dfsA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 2dfs MYOSIN-5A
(Gallus
gallus) 		4 / 6 ASN A 410
MET A 371
LEU A 403
VAL A 249
 None
 1.09A 4okbA-2dfsA:
undetectable		 4okbA-2dfsA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2dfs MYOSIN-5A
(Gallus
gallus) 		4 / 7 LEU A 277
LEU A 411
MET A 305
ILE A 407
 None
 1.01A 4okwA-2dfsA:
undetectable		 4okwA-2dfsA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 12 LEU A 682
PHE A 673
ILE A 110
GLU A  82
LEU A 688
 None
 1.42A 4r88B-2dfsA:
undetectable		 4r88B-2dfsA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 12 LEU A 682
PHE A 673
ILE A 110
GLU A  82
LEU A 688
 None
 1.43A 4r88C-2dfsA:
undetectable		 4r88C-2dfsA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 12 LEU A 682
PHE A 673
ILE A 110
GLU A  82
LEU A 688
 None
 1.43A 4r88D-2dfsA:
undetectable		 4r88D-2dfsA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 12 LEU A 682
PHE A 673
ILE A 110
GLU A  82
LEU A 688
 None
 1.43A 4r88F-2dfsA:
undetectable		 4r88F-2dfsA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 2dfs MYOSIN-5A
(Gallus
gallus) 		4 / 5 ILE A  67
PRO A  65
HIS A  81
VAL A  91
 None
 1.30A 4s0vA-2dfsA:
undetectable		 4s0vA-2dfsA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2dfs MYOSIN-5A
(Gallus
gallus) 		4 / 6 GLU A 539
PHE A 538
PHE A 548
TYR A 559
 None
 1.26A 4uciA-2dfsA:
undetectable		 4uciA-2dfsA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2dfs MYOSIN-5A
(Gallus
gallus) 		4 / 7 GLU A 539
PHE A 538
PHE A 548
TYR A 559
 None
 1.27A 4uciB-2dfsA:
undetectable		 4uciB-2dfsA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 11 VAL A 572
GLN A 576
PHE A 340
GLY A 336
ILE A 332
 None
 1.40A 4zvmA-2dfsA:
undetectable
4zvmB-2dfsA:
undetectable		 4zvmA-2dfsA:
11.55
4zvmB-2dfsA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2dfs MYOSIN-5A
(Gallus
gallus) 		4 / 8 ARG A 378
GLU A 574
GLU A 575
THR A 386
 None
 1.05A 5syjA-2dfsA:
undetectable		 5syjA-2dfsA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 12 ILE A 325
VAL A 416
VAL A 419
LEU A 588
LEU A 592
 None
 1.19A 5tiwA-2dfsA:
undetectable		 5tiwA-2dfsA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 12 PHE A  93
PHE A 673
ILE A 662
ALA A 109
GLY A  70
 None
 1.02A 5veuA-2dfsA:
undetectable		 5veuA-2dfsA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 2dfs MYOSIN-5A
(Gallus
gallus) 		5 / 12 PHE A  93
PHE A 673
ILE A 662
ALA A 109
GLY A  70
 None
 1.06A 5veuH-2dfsA:
0.0		 5veuH-2dfsA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 2dfs MYOSIN-5A
(Gallus
gallus) 		4 / 8 GLY A 686
ASN A 458
GLN A 462
PHE A 553
 None
 0.77A 5xu8A-2dfsA:
undetectable		 5xu8A-2dfsA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2dfs MYOSIN-5A
(Gallus
gallus) 		3 / 3 TYR A 456
HIS A 645
MET A 648
 None
 1.03A 6af6A-2dfsA:
1.6		 6af6A-2dfsA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 2dfs MYOSIN-5A
(Gallus
gallus) 		3 / 3 TYR A  79
PRO A  65
LEU A  68
 None
 0.76A 6beoA-2dfsA:
undetectable		 6beoA-2dfsA:
0.88