SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dfv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  67
LEU A 179
LEU A 182
LEU A 307
 None
NAD  A1401 (-3.9A)
None
None
 1.20A 1a4lD-2dfvA:
undetectable		 1a4lD-2dfvA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A 182
PRO A 153
LEU A 179
ARG A 204
 None
None
NAD  A1401 (-3.9A)
NAD  A1401 (-3.1A)
 1.26A 1hrkB-2dfvA:
2.8		 1hrkB-2dfvA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A 312
SER A 190
LEU A 182
LEU A 154
 None
 1.13A 1yajA-2dfvA:
2.6		 1yajA-2dfvA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 THR A  11
PRO A  13
PRO A  62
 None
 0.84A 2d55C-2dfvA:
undetectable		 2d55C-2dfvA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A 182
PRO A 153
LEU A 179
ARG A 204
 None
None
NAD  A1401 (-3.9A)
NAD  A1401 (-3.1A)
 1.40A 2hrcA-2dfvA:
undetectable		 2hrcA-2dfvA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A 182
PRO A 153
LEU A 179
ARG A 204
 None
None
NAD  A1401 (-3.9A)
NAD  A1401 (-3.1A)
 1.22A 2hrcB-2dfvA:
3.1		 2hrcB-2dfvA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 GLN A 252
LYS A 226
VAL A 228
 None
 0.85A 2jfaB-2dfvA:
undetectable		 2jfaB-2dfvA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A 182
PRO A 153
LEU A 179
ARG A 204
 None
None
NAD  A1401 (-3.9A)
NAD  A1401 (-3.1A)
 1.31A 2pnjB-2dfvA:
3.0		 2pnjB-2dfvA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A 182
PRO A 153
LEU A 179
ARG A 204
 None
None
NAD  A1401 (-3.9A)
NAD  A1401 (-3.1A)
 1.29A 2qd2A-2dfvA:
2.5		 2qd2A-2dfvA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 ARG A 204
GLY A 212
ALA A 213
ASP A 214
VAL A 171
 NAD  A1401 (-3.1A)
None
None
None
None
 0.93A 3ekwB-2dfvA:
undetectable		 3ekwB-2dfvA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  43
CYH A  42
SER A  40
VAL A 119
ILE A  48
 NAD  A1401 ( 4.7A)
NAD  A1401 (-3.3A)
None
None
None
 1.29A 3g9eA-2dfvA:
undetectable		 3g9eA-2dfvA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A 182
PRO A 153
LEU A 179
ARG A 204
 None
None
NAD  A1401 (-3.9A)
NAD  A1401 (-3.1A)
 1.41A 3hcoA-2dfvA:
3.1		 3hcoA-2dfvA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 318
LEU A 150
ALA A  38
ALA A  70
 None
 0.84A 3r9tB-2dfvA:
undetectable		 3r9tB-2dfvA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 266
GLU A 242
SER A 264
 NAD  A1401 (-4.3A)
None
None
 0.62A 4ccqA-2dfvA:
3.5		 4ccqA-2dfvA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  66
ILE A  48
PHE A 325
ILE A   8
PHE A 345
 None
 1.28A 4fglA-2dfvA:
4.4
4fglB-2dfvA:
4.4		 4fglA-2dfvA:
23.08
4fglB-2dfvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A  38
GLN A  63
GLY A  66
SER A  40
GLU A  68
 None
 1.33A 5hfjG-2dfvA:
3.3		 5hfjG-2dfvA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A  96
GLN A 107
CYH A 103
 None
None
ZN  A1001 (-2.2A)
 0.72A 5icxA-2dfvA:
undetectable
5icxE-2dfvA:
undetectable		 5icxA-2dfvA:
20.11
5icxE-2dfvA:
3.46