SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dg6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 TRP A  87
VAL A 130
PRO A 129
 None
 0.88A 1rg1A-2dg6A:
undetectable		 1rg1A-2dg6A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 TRP A  87
VAL A 130
PRO A 129
 None
 0.87A 1rh0A-2dg6A:
undetectable		 1rh0A-2dg6A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 7 GLY A  57
GLN A 192
VAL A  59
PRO A  90
 None
 0.98A 1rxcC-2dg6A:
undetectable		 1rxcC-2dg6A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 7 GLY A  57
GLN A 192
VAL A  59
PRO A  90
 None
 1.02A 1rxcD-2dg6A:
undetectable		 1rxcD-2dg6A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 LEU A  89
ALA A  84
ALA A  85
VAL A 189
LEU A  49
 None
 1.14A 3bszE-2dg6A:
undetectable		 3bszE-2dg6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 LEU A  89
VAL A  67
SER A 128
LEU A  82
VAL A  80
 None
 1.02A 3tbgA-2dg6A:
undetectable		 3tbgA-2dg6A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 7 GLY A  11
SER A  10
SER A   7
LEU A  47
 None
 0.81A 3v7pA-2dg6A:
undetectable		 3v7pA-2dg6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 7 GLY A  57
GLN A 192
VAL A  59
PRO A  90
 None
 1.05A 4e1vB-2dg6A:
undetectable		 4e1vB-2dg6A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 8 GLY A  57
GLN A 192
VAL A  59
PRO A  90
 None
 1.00A 4e1vG-2dg6A:
undetectable		 4e1vG-2dg6A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 VAL A  12
SER A  13
THR A  16
 None
 0.24A 4luhA-2dg6A:
undetectable		 4luhA-2dg6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 MET A 161
ASP A 169
PHE A 170
 None
 1.02A 4xeyB-2dg6A:
undetectable		 4xeyB-2dg6A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 8 LEU A  53
GLY A  57
VAL A  59
ALA A  64
LEU A  68
 None
 1.09A 4zauA-2dg6A:
undetectable		 4zauA-2dg6A:
21.41