SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dg8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Streptomyces
coelicolor) 		3 / 3 LEU A 106
HIS A  67
ILE A  68
 None
 0.69A 1s9pB-2dg8A:
undetectable		 1s9pB-2dg8A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Streptomyces
coelicolor) 		5 / 10 ILE A  35
ALA A  17
ALA A  39
ARG A  63
ALA A  16
 None
 1.15A 2aclC-2dg8A:
undetectable		 2aclC-2dg8A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Streptomyces
coelicolor) 		4 / 7 VAL A  93
SER A  97
ARG A 158
LEU A 169
 None
 1.12A 2f78B-2dg8A:
undetectable		 2f78B-2dg8A:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Streptomyces
coelicolor) 		5 / 8 ARG A  34
LEU A  21
ALA A  60
ILE A  14
ILE A  53
 None
 1.38A 2o4nB-2dg8A:
undetectable		 2o4nB-2dg8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Streptomyces
coelicolor) 		5 / 12 LEU A  57
ALA A  60
LEU A  19
LEU A  21
LEU A 110
 None
 1.04A 3hm1A-2dg8A:
undetectable		 3hm1A-2dg8A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Streptomyces
coelicolor) 		4 / 7 VAL A  89
VAL A  93
LEU A  96
SER A  97
 None
 0.53A 3hs6B-2dg8A:
undetectable		 3hs6B-2dg8A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Streptomyces
coelicolor) 		4 / 8 ILE A 177
GLN A 146
ALA A 149
LEU A 150
 None
 0.76A 3ozwA-2dg8A:
undetectable		 3ozwA-2dg8A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Streptomyces
coelicolor) 		4 / 7 LEU A 135
LEU A 147
GLU A 152
ILE A 151
 None
 0.78A 3s56B-2dg8A:
undetectable		 3s56B-2dg8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Streptomyces
coelicolor) 		5 / 11 LEU A  57
ALA A  60
LEU A  19
LEU A  21
LEU A 110
 None
 1.10A 3uudA-2dg8A:
undetectable		 3uudA-2dg8A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Streptomyces
coelicolor) 		4 / 7 HIS A  32
ILE A  14
ILE A  35
ALA A  36
 None
 0.89A 4lv9A-2dg8A:
undetectable		 4lv9A-2dg8A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Streptomyces
coelicolor) 		4 / 7 HIS A  32
ILE A  14
ILE A  35
ALA A  36
 None
 0.87A 4lv9B-2dg8A:
undetectable		 4lv9B-2dg8A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Streptomyces
coelicolor) 		5 / 10 LEU A  57
ALA A  60
LEU A  19
LEU A  21
LEU A 110
 None
 1.05A 5hyrA-2dg8A:
undetectable		 5hyrA-2dg8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Streptomyces
coelicolor) 		5 / 12 LEU A  57
ALA A  60
LEU A  19
LEU A  21
LEU A 110
 None
 1.03A 5toaA-2dg8A:
undetectable		 5toaA-2dg8A:
23.72