SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dgd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE
(Sulfurisphaera
tokodaii) 		4 / 8 LEU A  56
GLU A  53
ILE A  85
TYR A  72
 None
 0.77A 1qvtA-2dgdA:
undetectable		 1qvtA-2dgdA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE
(Sulfurisphaera
tokodaii) 		4 / 8 LYS A  86
ILE A  85
GLU A  97
ILE A  94
 None
 0.92A 2j9dJ-2dgdA:
undetectable
2j9dK-2dgdA:
undetectable
2j9dL-2dgdA:
undetectable		 2j9dJ-2dgdA:
18.39
2j9dK-2dgdA:
18.39
2j9dL-2dgdA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE
(Sulfurisphaera
tokodaii) 		4 / 7 ASN A  16
GLY A  18
MET A  19
SER A  35
 None
 1.20A 2o5yH-2dgdA:
undetectable
2o5yL-2dgdA:
undetectable		 2o5yH-2dgdA:
21.46
2o5yL-2dgdA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE
(Sulfurisphaera
tokodaii) 		5 / 12 ALA A 204
LEU A 102
SER A  98
SER A 201
TYR A 176
 None
 1.44A 3bxoB-2dgdA:
2.0		 3bxoB-2dgdA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  89
GLU A  45
GLU A 202
GLU A  96
HIS A  81
 None
 1.43A 4a97A-2dgdA:
0.0
4a97B-2dgdA:
0.0		 4a97A-2dgdA:
20.66
4a97B-2dgdA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_F_ZPCF1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLU A 202
GLU A  96
HIS A  81
ILE A  89
GLU A  45
 None
 1.38A 4a97F-2dgdA:
0.0
4a97J-2dgdA:
0.0		 4a97F-2dgdA:
20.66
4a97J-2dgdA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE
(Sulfurisphaera
tokodaii) 		4 / 8 LEU A 103
VAL A  99
VAL A 188
ILE A 177
 None
 0.92A 4l4cB-2dgdA:
undetectable		 4l4cB-2dgdA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE
(Sulfurisphaera
tokodaii) 		5 / 11 THR A 180
SER A 151
ASP A  22
TYR A  72
GLY A  73
 None
 1.47A 4qb9F-2dgdA:
0.0		 4qb9F-2dgdA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE
(Sulfurisphaera
tokodaii) 		4 / 6 ILE A  85
PHE A  52
ARG A  74
ILE A  11
 None
 1.21A 4zzcA-2dgdA:
undetectable
4zzcB-2dgdA:
undetectable		 4zzcA-2dgdA:
22.62
4zzcB-2dgdA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE
(Sulfurisphaera
tokodaii) 		4 / 6 ILE A 113
TYR A 176
PHE A 134
THR A  78
 None
 1.16A 5g08A-2dgdA:
undetectable		 5g08A-2dgdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE
(Sulfurisphaera
tokodaii) 		3 / 3 SER A  32
LEU A 220
MET A  26
 None
 0.76A 5ikrB-2dgdA:
undetectable		 5ikrB-2dgdA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE
(Sulfurisphaera
tokodaii) 		4 / 8 TYR A 176
SER A 201
THR A 184
PRO A  95
 None
 0.88A 5jhdE-2dgdA:
undetectable
5jhdG-2dgdA:
undetectable		 5jhdE-2dgdA:
26.49
5jhdG-2dgdA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE
(Sulfurisphaera
tokodaii) 		3 / 3 HIS A  81
HIS A  83
ARG A  87
 None
 0.74A 6b58A-2dgdA:
undetectable		 6b58A-2dgdA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE
(Sulfurisphaera
tokodaii) 		3 / 3 VAL A 126
GLU A 127
ILE A 136
 None
 0.59A 6f7lB-2dgdA:
undetectable		 6f7lB-2dgdA:
16.93