SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dgk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 6 PHE A 380
TYR A 363
LEU A 445
VAL A 406
 None
 1.13A 1dz4A-2dgkA:
undetectable		 1dz4A-2dgkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 6 PHE A 380
TYR A 363
LEU A 445
VAL A 406
 None
 1.08A 1dz4B-2dgkA:
undetectable		 1dz4B-2dgkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 5 PHE A 380
TYR A 363
LEU A 360
VAL A 406
 None
 1.22A 1dz6A-2dgkA:
undetectable		 1dz6A-2dgkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		5 / 12 TYR A 339
GLY A 247
PHE A 331
VAL A 104
ALA A 280
 None
 1.36A 1e3vA-2dgkA:
0.0		 1e3vA-2dgkA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 7 PHE A 380
TYR A 363
LEU A 445
VAL A 406
 None
 1.07A 1t87A-2dgkA:
undetectable		 1t87A-2dgkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 5 PHE A 380
TYR A 363
LEU A 360
VAL A 406
 None
 1.22A 1t88B-2dgkA:
undetectable		 1t88B-2dgkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 5 PHE A 380
TYR A 363
LEU A 445
VAL A 406
 None
 1.08A 1t88B-2dgkA:
undetectable		 1t88B-2dgkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		5 / 11 LEU A 227
ILE A 203
PRO A 155
ASN A 201
MET A 194
 None
 1.32A 2ft9A-2dgkA:
undetectable		 2ft9A-2dgkA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 5 TRP A 108
ALA A 244
LEU A 107
ALA A 272
 None
 1.25A 2jstA-2dgkA:
undetectable
2jstB-2dgkA:
undetectable		 2jstA-2dgkA:
8.18
2jstB-2dgkA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 5 PHE A 380
TYR A 363
LEU A 360
VAL A 406
 None
 1.21A 2m56A-2dgkA:
undetectable		 2m56A-2dgkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 5 PHE A 380
TYR A 363
LEU A 445
VAL A 406
 None
 1.12A 2m56A-2dgkA:
undetectable		 2m56A-2dgkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		3 / 3 LEU A 223
PRO A 222
ARG A 193
 None
 0.62A 2qd5A-2dgkA:
3.5		 2qd5A-2dgkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 5 GLN A 327
ALA A 280
GLN A  65
ARG A 427
 None
 1.44A 2z0aA-2dgkA:
undetectable		 2z0aA-2dgkA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 6 PHE A 380
TYR A 363
LEU A 445
VAL A 406
 None
 1.08A 2zawA-2dgkA:
undetectable		 2zawA-2dgkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 6 PHE A 380
TYR A 363
LEU A 445
VAL A 406
 None
 1.08A 2zuhA-2dgkA:
undetectable		 2zuhA-2dgkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		5 / 8 PHE A 380
TYR A 363
LEU A 445
LEU A 392
VAL A 406
 None
 1.04A 2zujA-2dgkA:
undetectable		 2zujA-2dgkA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		5 / 8 PHE A 429
LEU A 399
VAL A 406
VAL A 378
LEU A 353
 None
 1.49A 2zujA-2dgkA:
undetectable		 2zujA-2dgkA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		3 / 3 GLY A 125
GLY A 274
GLY A 285
 PLP  A1500 (-3.5A)
None
None
 0.42A 3bogD-2dgkA:
undetectable		 3bogD-2dgkA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		5 / 12 SER A 271
GLU A 218
VAL A 211
GLY A 210
HIS A 241
 None
 1.35A 3f8wB-2dgkA:
undetectable		 3f8wB-2dgkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 6 PHE A 380
TYR A 363
LEU A 445
VAL A 406
 None
 1.08A 3fwgA-2dgkA:
undetectable		 3fwgA-2dgkA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 7 PHE A 380
TYR A 363
LEU A 445
VAL A 406
 None
 1.08A 3fwgB-2dgkA:
undetectable		 3fwgB-2dgkA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 7 GLY A 428
CYH A  64
PHE A  63
PHE A 277
 None
None
PLP  A1500 ( 4.7A)
None
 1.11A 3ko0D-2dgkA:
undetectable
3ko0E-2dgkA:
0.0		 3ko0D-2dgkA:
12.00
3ko0E-2dgkA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		5 / 12 ALA A 245
GLY A 248
TRP A 286
GLY A 210
HIS A 241
 PLP  A1500 (-3.4A)
None
None
None
None
 1.01A 3ou6B-2dgkA:
undetectable		 3ou6B-2dgkA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		5 / 12 ALA A 245
GLY A 248
TRP A 286
GLY A 210
HIS A 241
 PLP  A1500 (-3.4A)
None
None
None
None
 1.05A 3ou7B-2dgkA:
undetectable		 3ou7B-2dgkA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 8 VAL A 206
TRP A 166
HIS A 241
PHE A 169
 None
 1.43A 3v35A-2dgkA:
undetectable		 3v35A-2dgkA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 6 PHE A 380
TYR A 363
LEU A 445
VAL A 406
 None
 1.06A 3wrhE-2dgkA:
undetectable		 3wrhE-2dgkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 6 PHE A 380
TYR A 363
LEU A 445
VAL A 406
 None
 1.08A 3wrjE-2dgkA:
undetectable		 3wrjE-2dgkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 6 GLU A 364
LYS A 381
PRO A 362
GLU A 386
 None
 1.26A 4a7tF-2dgkA:
undetectable		 4a7tF-2dgkA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 6 PHE A 380
TYR A 363
LEU A 445
VAL A 406
 None
 1.07A 4g3rA-2dgkA:
undetectable		 4g3rA-2dgkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		5 / 12 VAL A 205
PRO A 207
PHE A 188
THR A 214
GLY A 215
 None
 1.28A 4hvcB-2dgkA:
undetectable		 4hvcB-2dgkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 6 PHE A 230
ILE A 236
ARG A 144
VAL A 158
 None
 1.39A 4mk4B-2dgkA:
4.2		 4mk4B-2dgkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 7 PHE A 230
ILE A 236
ASN A 156
ARG A 144
 None
 1.07A 4o7gA-2dgkA:
undetectable
4o7gB-2dgkA:
undetectable		 4o7gA-2dgkA:
19.91
4o7gB-2dgkA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		5 / 12 VAL A 205
PRO A 207
PHE A 188
THR A 214
GLY A 215
 None
 1.27A 4olfA-2dgkA:
2.0		 4olfA-2dgkA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 7 TYR A 347
GLY A 210
SER A 246
LEU A 250
 None
 1.16A 5bphB-2dgkA:
undetectable		 5bphB-2dgkA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 6 TYR A 347
GLY A 210
SER A 246
LEU A 250
 None
 1.17A 5bphD-2dgkA:
undetectable		 5bphD-2dgkA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 6 PHE A  63
SER A 273
ALA A 245
HIS A 275
 PLP  A1500 ( 4.7A)
PLP  A1500 (-2.8A)
PLP  A1500 (-3.4A)
PLP  A1500 (-3.8A)
 1.20A 5dzkB-2dgkA:
undetectable
5dzkP-2dgkA:
undetectable		 5dzkB-2dgkA:
20.62
5dzkP-2dgkA:
0.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 6 PHE A  63
SER A 273
ALA A 245
HIS A 275
 PLP  A1500 ( 4.7A)
PLP  A1500 (-2.8A)
PLP  A1500 (-3.4A)
PLP  A1500 (-3.8A)
 1.19A 5dzkg-2dgkA:
undetectable
5dzku-2dgkA:
undetectable		 5dzkg-2dgkA:
20.62
5dzku-2dgkA:
0.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		5 / 12 ALA A 136
LEU A 295
PHE A 331
GLY A 278
PHE A 262
 None
 1.15A 5eshA-2dgkA:
undetectable		 5eshA-2dgkA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_C_STIC302_1
(DEOXYCYTIDINE KINASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		5 / 12 ILE A 242
MET A 194
PRO A 191
LEU A 227
GLU A 218
 None
 1.22A 5mqtC-2dgkA:
undetectable		 5mqtC-2dgkA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 6 GLY A 133
SER A 127
THR A 123
VAL A 287
 None
PLP  A1500 (-2.6A)
None
None
 1.06A 5ysiA-2dgkA:
undetectable		 5ysiA-2dgkA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		3 / 3 GLY A 210
ASP A 243
ILE A 270
 None
PLP  A1500 (-2.9A)
None
 0.55A 6dgxB-2dgkA:
undetectable		 6dgxB-2dgkA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 2dgk GLUTAMATE
DECARBOXYLASE BETA
(Escherichia
coli) 		4 / 7 PHE A 331
LEU A 107
GLY A 248
GLY A 125
 None
None
None
PLP  A1500 (-3.5A)
 0.72A 6eu9D-2dgkA:
undetectable		 6eu9D-2dgkA:
11.29