SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dgx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2dgx KIAA0430 PROTEIN
(Homo
sapiens) 		5 / 8 ILE A 622
LEU A 571
ILE A 562
VAL A 559
ILE A 627
 None
 1.35A 1linA-2dgxA:
undetectable		 1linA-2dgxA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2dgx KIAA0430 PROTEIN
(Homo
sapiens) 		4 / 4 SER A 550
GLY A 549
GLY A 552
GLY A 634
 None
 0.83A 3bogB-2dgxA:
undetectable
3bogD-2dgxA:
undetectable		 3bogB-2dgxA:
undetectable
3bogD-2dgxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2dgx KIAA0430 PROTEIN
(Homo
sapiens) 		3 / 3 TYR A 596
LEU A 574
ARG A 565
 None
 0.80A 3sufB-2dgxA:
undetectable		 3sufB-2dgxA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2dgx KIAA0430 PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 602
LEU A 598
ILE A 562
ILE A 627
ILE A 622
 None
 0.79A 4y0rA-2dgxA:
undetectable		 4y0rA-2dgxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 2dgx KIAA0430 PROTEIN
(Homo
sapiens) 		3 / 3 ASP A 563
ARG A 565
TYR A 564
 None
 0.98A 5a7mA-2dgxA:
undetectable		 5a7mA-2dgxA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 2dgx KIAA0430 PROTEIN
(Homo
sapiens) 		3 / 3 ASP A 563
ARG A 565
TYR A 564
 None
 0.96A 5a7mB-2dgxA:
undetectable		 5a7mB-2dgxA:
9.64