SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dh3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_2
(GLUCOAMYLASE-471)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		4 / 5 SER A 282
TRP A 217
LEU A 275
TRP A 262
 None
 1.20A 1agmA-2dh3A:
undetectable		 1agmA-2dh3A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		4 / 5 GLU A 504
LEU A 522
LEU A 496
LEU A 523
 None
 1.08A 1np1A-2dh3A:
undetectable		 1np1A-2dh3A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		5 / 12 TYR A 149
LEU A 150
GLY A 138
ILE A 126
LEU A 419
 None
 1.04A 1p91B-2dh3A:
undetectable		 1p91B-2dh3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		3 / 3 ASP A 128
ILE A 179
VAL A 203
 None
 0.71A 2avvD-2dh3A:
undetectable		 2avvD-2dh3A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		5 / 10 LEU A 192
PHE A 189
LEU A 143
LEU A 129
ILE A 163
 None
 0.82A 2bxeB-2dh3A:
undetectable		 2bxeB-2dh3A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		5 / 12 LEU A 192
PHE A 189
LEU A 143
LEU A 129
ILE A 163
 None
 0.87A 2bxqA-2dh3A:
undetectable		 2bxqA-2dh3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		5 / 12 ALA A 445
ALA A 442
ALA A 475
GLY A 448
GLY A 446
 None
 1.07A 2igtA-2dh3A:
undetectable		 2igtA-2dh3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		6 / 12 TYR A 452
ALA A 445
ALA A 442
ALA A 475
GLY A 448
GLY A 446
 None
 1.25A 2igtB-2dh3A:
undetectable		 2igtB-2dh3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		5 / 12 TYR A 452
ALA A 445
ALA A 442
ALA A 475
GLY A 446
 None
 1.15A 2igtC-2dh3A:
undetectable		 2igtC-2dh3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		3 / 3 LEU A 488
PRO A 489
LEU A 510
 None
 0.54A 2po5B-2dh3A:
undetectable		 2po5B-2dh3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		3 / 3 LEU A 488
PRO A 489
LEU A 510
 None
 0.51A 2po7B-2dh3A:
undetectable		 2po7B-2dh3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		4 / 8 THR A 314
TYR A 321
TRP A 332
TYR A 303
 None
 1.38A 2xz5A-2dh3A:
undetectable
2xz5C-2dh3A:
undetectable		 2xz5A-2dh3A:
19.46
2xz5C-2dh3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		5 / 12 GLY A 410
SER A 403
SER A 420
GLY A 416
SER A 417
 None
 1.07A 3g2oA-2dh3A:
undetectable		 3g2oA-2dh3A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		4 / 5 LEU A 510
GLN A 478
LEU A 488
GLU A 511
 None
 1.15A 3h5gA-2dh3A:
undetectable
3h5gB-2dh3A:
undetectable		 3h5gA-2dh3A:
6.89
3h5gB-2dh3A:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		3 / 3 LEU A 488
PRO A 489
LEU A 510
 None
 0.32A 3hcrA-2dh3A:
undetectable		 3hcrA-2dh3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		5 / 12 ALA A 137
PHE A 132
LEU A 129
LEU A 160
LEU A 140
 None
 0.91A 3k2hA-2dh3A:
undetectable		 3k2hA-2dh3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		5 / 12 LEU A 488
PHE A 525
LEU A 523
GLY A 476
SER A 451
 None
 1.22A 3tbgA-2dh3A:
undetectable		 3tbgA-2dh3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		5 / 12 LEU A 488
PHE A 525
LEU A 523
GLY A 476
SER A 451
 None
 1.24A 3tbgC-2dh3A:
undetectable		 3tbgC-2dh3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		5 / 12 LEU A 193
ALA A 196
LEU A 140
ILE A 126
LEU A 129
 None
 1.23A 4j24D-2dh3A:
undetectable		 4j24D-2dh3A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		4 / 4 ILE A 276
VAL A 203
VAL A 159
ARG A 125
 None
 1.25A 4m6tA-2dh3A:
undetectable		 4m6tA-2dh3A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		5 / 10 LEU A 513
LEU A 515
ALA A 475
LEU A 466
LEU A 477
 None
 1.18A 4p65A-2dh3A:
undetectable
4p65B-2dh3A:
undetectable
4p65F-2dh3A:
undetectable
4p65H-2dh3A:
undetectable		 4p65A-2dh3A:
4.29
4p65B-2dh3A:
5.72
4p65F-2dh3A:
5.72
4p65H-2dh3A:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		5 / 12 LEU A 153
VAL A 155
LEU A 129
ILE A 126
LEU A 192
 None
 1.13A 4y0qA-2dh3A:
undetectable		 4y0qA-2dh3A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		3 / 3 ARG A 247
ASP A 206
TYR A 211
 None
 0.86A 4yo9B-2dh3A:
undetectable		 4yo9B-2dh3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		4 / 8 PHE A 357
PRO A 363
LEU A 359
LEU A 356
 None
 1.14A 5dzkd-2dh3A:
2.4
5dzkr-2dh3A:
undetectable		 5dzkd-2dh3A:
19.39
5dzkr-2dh3A:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		4 / 8 PHE A 357
PRO A 363
LEU A 359
LEU A 356
 None
 1.11A 5dzkF-2dh3A:
2.4
5dzkT-2dh3A:
undetectable		 5dzkF-2dh3A:
19.39
5dzkT-2dh3A:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		4 / 6 LEU A 304
LEU A 334
SER A 335
THR A 300
 None
 1.13A 5l4iB-2dh3A:
undetectable		 5l4iB-2dh3A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		4 / 4 GLN A 499
THR A 498
GLU A 504
LEU A 508
 None
 1.32A 5m66A-2dh3A:
undetectable		 5m66A-2dh3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		3 / 3 LYS A 116
LEU A 298
ASP A 296
 None
 0.76A 5zv2A-2dh3A:
undetectable		 5zv2A-2dh3A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens) 		4 / 6 ASP A 439
LEU A 488
SER A 487
PHE A 525
 ZN  A 601 (-2.2A)
None
None
None
 1.02A 6ekuA-2dh3A:
undetectable		 6ekuA-2dh3A:
20.00