SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dh4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 185
ALA A 188
LEU A 128
ILE A  64
LEU A  57
 None
 1.15A 1g50A-2dh4A:
undetectable		 1g50A-2dh4A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 185
ALA A 188
LEU A 128
ILE A  64
LEU A  57
 None
 1.11A 1pcgA-2dh4A:
undetectable		 1pcgA-2dh4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 11 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.72A 1rqjA-2dh4A:
23.0		 1rqjA-2dh4A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 11 SER A  76
ASP A  80
ASP A  84
GLN A 147
LYS A 174
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
None
None
 0.81A 1rqjA-2dh4A:
23.0		 1rqjA-2dh4A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 11 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.71A 1rqjB-2dh4A:
23.1		 1rqjB-2dh4A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		7 / 11 SER A  76
ASP A  80
ASP A  84
GLN A 147
LYS A 174
THR A 175
GLN A 211
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
None
None
None
None
 0.81A 1rqjB-2dh4A:
23.1		 1rqjB-2dh4A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 11 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.65A 1yhlA-2dh4A:
26.4		 1yhlA-2dh4A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 11 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.65A 1yq7A-2dh4A:
27.0		 1yq7A-2dh4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.60A 1yv5A-2dh4A:
27.0		 1yv5A-2dh4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 9 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.62A 1zw5A-2dh4A:
26.9		 1zw5A-2dh4A:
24.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 9 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
GLN A 211
ASP A 214
LYS A 238
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
MG  A 341 ( 4.6A)
 0.69A 2e91A-2dh4A:
42.8		 2e91A-2dh4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 9 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.52A 2e91A-2dh4A:
42.8		 2e91A-2dh4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 9 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
LYS A 238
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
MG  A 341 ( 4.6A)
 0.56A 2e91B-2dh4A:
39.3		 2e91B-2dh4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		7 / 9 ASP A  80
ASP A  84
ARG A  89
LYS A 174
THR A 175
GLN A 211
ASP A 214
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
 0.44A 2f89F-2dh4A:
26.9		 2f89F-2dh4A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 11 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.61A 2f8cF-2dh4A:
3.2		 2f8cF-2dh4A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.60A 2f8zF-2dh4A:
26.6		 2f8zF-2dh4A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 12 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.44A 2f94F-2dh4A:
14.1		 2f94F-2dh4A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.64A 2f9kF-2dh4A:
27.0		 2f9kF-2dh4A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 9 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
 0.62A 2o1oA-2dh4A:
25.7		 2o1oA-2dh4A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
LYS A 238
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
MG  A 341 ( 4.6A)
 0.92A 2o1oB-2dh4A:
26.1		 2o1oB-2dh4A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 10 ASP A  80
ASP A  84
GLN A 147
GLN A 211
ASP A 214
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
None
None
None
 1.47A 2q58A-2dh4A:
25.7		 2q58A-2dh4A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 10 ASP A  80
ASP A  84
THR A 175
GLN A 211
ASP A 214
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
None
None
None
 1.40A 2q58A-2dh4A:
25.7		 2q58A-2dh4A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 10 LEU A  77
ASP A  80
ARG A  89
GLN A 147
ASP A 233
 None
MG  A 341 (-2.6A)
MG  A 341 ( 4.6A)
None
None
 1.41A 2q58A-2dh4A:
25.7		 2q58A-2dh4A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		7 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
GLN A 211
ASP A 215
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
 0.87A 2q58A-2dh4A:
25.7		 2q58A-2dh4A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
LYS A 174
THR A 175
GLN A 211
ASP A 215
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
 0.77A 2q58A-2dh4A:
25.7		 2q58A-2dh4A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		6 / 9 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
LYS A 238
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
MG  A 341 ( 4.6A)
 1.09A 2q58B-2dh4A:
25.7		 2q58B-2dh4A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		7 / 9 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
 0.77A 2q58B-2dh4A:
25.7		 2q58B-2dh4A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
 0.61A 2qisA-2dh4A:
27.0		 2qisA-2dh4A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 168
MET A 303
GLN A 299
PHE A 296
 None
 0.97A 2weyB-2dh4A:
undetectable		 2weyB-2dh4A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 243
ILE A 297
LEU A 247
LEU A 168
 None
 0.87A 3adxA-2dh4A:
2.0		 3adxA-2dh4A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 9 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.73A 3ez3A-2dh4A:
27.2		 3ez3A-2dh4A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 9 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.62A 3ez3B-2dh4A:
27.1		 3ez3B-2dh4A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 9 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.70A 3ez3C-2dh4A:
27.2		 3ez3C-2dh4A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.67A 3ez3D-2dh4A:
27.1		 3ez3D-2dh4A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 10 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.64A 3ibaA-2dh4A:
14.4		 3ibaA-2dh4A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 9 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.74A 3ldwA-2dh4A:
27.1		 3ldwA-2dh4A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 9 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.64A 3ldwB-2dh4A:
27.1		 3ldwB-2dh4A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 9 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.72A 3ldwC-2dh4A:
27.2		 3ldwC-2dh4A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 9 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.67A 3ldwD-2dh4A:
27.1		 3ldwD-2dh4A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 292
GLN A 164
LEU A 168
PHE A 241
 None
 1.16A 3ls4L-2dh4A:
undetectable		 3ls4L-2dh4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 11 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.65A 3n45F-2dh4A:
27.1		 3n45F-2dh4A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.64A 3n46F-2dh4A:
26.9		 3n46F-2dh4A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 185
ALA A 188
LEU A 128
ILE A  64
LEU A  57
 None
 1.09A 3q95A-2dh4A:
undetectable		 3q95A-2dh4A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 185
ALA A 188
LEU A 128
ILE A  64
LEU A  57
 None
 1.09A 3q95B-2dh4A:
undetectable		 3q95B-2dh4A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  72
SER A  75
ALA A 108
LEU A 178
 None
 0.96A 3ravA-2dh4A:
2.3		 3ravA-2dh4A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 9 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
 0.65A 4kfaA-2dh4A:
26.7		 4kfaA-2dh4A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.60A 4kpdA-2dh4A:
26.7		 4kpdA-2dh4A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 9 LEU A  77
ASP A  80
ASP A  84
ARG A  89
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
 0.49A 4kpjA-2dh4A:
26.8		 4kpjA-2dh4A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.66A 4kq5A-2dh4A:
6.0		 4kq5A-2dh4A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.59A 4kqsA-2dh4A:
26.8		 4kqsA-2dh4A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
 0.62A 4n9uA-2dh4A:
7.1		 4n9uA-2dh4A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
THR A 175
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
 1.31A 4n9uA-2dh4A:
7.1		 4n9uA-2dh4A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 12 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
 0.39A 4ng6A-2dh4A:
26.6		 4ng6A-2dh4A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  77
ASP A  80
ASP A  84
ARG A  89
THR A 175
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
 1.27A 4ng6A-2dh4A:
26.6		 4ng6A-2dh4A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.55A 4nkeA-2dh4A:
26.8		 4nkeA-2dh4A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 9 LEU A  77
ASP A  80
ASP A  84
ARG A  89
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
 0.49A 4nkfA-2dh4A:
5.9		 4nkfA-2dh4A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.58A 4nuaA-2dh4A:
5.7		 4nuaA-2dh4A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 9 LEU A  77
ASP A  80
ASP A  84
ARG A  89
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
 0.46A 4oguA-2dh4A:
26.5		 4oguA-2dh4A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 9 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.63A 4p0vA-2dh4A:
6.6		 4p0vA-2dh4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 11 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.61A 4p0wA-2dh4A:
6.6		 4p0wA-2dh4A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
 0.61A 4q23A-2dh4A:
26.8		 4q23A-2dh4A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.63A 4rxdA-2dh4A:
9.0		 4rxdA-2dh4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.62A 4rxdB-2dh4A:
11.1		 4rxdB-2dh4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 10 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.62A 4rxdC-2dh4A:
5.1		 4rxdC-2dh4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		6 / 8 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
 0.43A 4umjA-2dh4A:
19.8		 4umjA-2dh4A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		6 / 8 SER A  76
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
 0.74A 4umjA-2dh4A:
19.8		 4umjA-2dh4A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		7 / 9 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
 0.49A 4umjB-2dh4A:
20.3		 4umjB-2dh4A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		7 / 9 SER A  76
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
 0.73A 4umjB-2dh4A:
20.3		 4umjB-2dh4A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  47
LEU A 183
LEU A 206
ASN A 204
ILE A 304
 None
 1.14A 4x20D-2dh4A:
undetectable		 4x20D-2dh4A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 216
LYS A 220
LEU A 283
GLU A 284
 None
 1.07A 4z4cA-2dh4A:
undetectable		 4z4cA-2dh4A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 216
LYS A 220
LEU A 283
GLU A 284
 None
 0.95A 4z4fA-2dh4A:
undetectable		 4z4fA-2dh4A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 12 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.59A 5cg5A-2dh4A:
26.6		 5cg5A-2dh4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		9 / 12 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.56A 5cg6A-2dh4A:
6.8		 5cg6A-2dh4A:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 9 LEU A  77
ASP A  80
ASP A  84
ARG A  89
LYS A 174
GLN A 211
ASP A 214
LYS A 238
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
MG  A 341 ( 4.6A)
 0.58A 5eroA-2dh4A:
32.5		 5eroA-2dh4A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 9 ASP A  80
ASP A  84
ARG A  89
LYS A 174
GLN A 211
ASP A 214
ASP A 215
LYS A 238
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
MG  A 341 ( 4.6A)
 0.55A 5eroB-2dh4A:
32.2		 5eroB-2dh4A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 9 ASP A  84
ARG A  89
GLN A 211
ASP A 214
ASP A 215
 MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
 1.29A 5eroB-2dh4A:
32.2		 5eroB-2dh4A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		8 / 10 ASP A  80
ASP A  81
ASP A  84
ARG A  89
LYS A 174
GLN A 211
ASP A 214
ASP A 215
 MG  A 341 (-2.6A)
None
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
 0.64A 5eroC-2dh4A:
32.2		 5eroC-2dh4A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 10 ASP A  80
ASP A  84
LYS A 174
GLN A 211
ASP A 214
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
None
None
None
 1.40A 5eroC-2dh4A:
32.2		 5eroC-2dh4A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		6 / 10 ASP A  80
ASP A  84
LYS A 174
GLN A 211
ASP A 215
LYS A 238
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
None
None
None
MG  A 341 ( 4.6A)
 0.92A 5eroC-2dh4A:
32.2		 5eroC-2dh4A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		6 / 10 ASP A  84
ASP A  81
ARG A  89
GLN A 211
ASP A 214
ASP A 215
 MG  A 341 (-3.0A)
None
MG  A 341 ( 4.6A)
None
None
None
 1.36A 5eroC-2dh4A:
32.2		 5eroC-2dh4A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 214
ASP A 215
ASP A  80
ASP A  81
LYS A 238
 None
None
MG  A 341 (-2.6A)
None
MG  A 341 ( 4.6A)
 0.80A 5eroC-2dh4A:
32.2		 5eroC-2dh4A:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 154
LYS A 174
ARG A 269
 None
 1.29A 6az3C-2dh4A:
0.0
6az3L-2dh4A:
0.0
6az3M-2dh4A:
undetectable		 6az3C-2dh4A:
11.95
6az3L-2dh4A:
11.47
6az3M-2dh4A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 237
LEU A 266
THR A 270
LEU A 279
 None
 0.80A 6czmD-2dh4A:
undetectable
6czmF-2dh4A:
undetectable		 6czmD-2dh4A:
21.97
6czmF-2dh4A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 277
ASP A 233
ILE A 243
 None
 0.43A 6dh0B-2dh4A:
undetectable		 6dh0B-2dh4A:
11.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		6 / 7 ASP A  80
ASP A  84
ARG A  89
GLN A 147
GLN A 211
LYS A 238
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
MG  A 341 ( 4.6A)
 0.77A 6g31A-2dh4A:
34.8		 6g31A-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		6 / 7 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
GLN A 211
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
 0.82A 6g31A-2dh4A:
34.8		 6g31A-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 6 ASP A  80
ASP A  84
ARG A  89
GLN A 147
GLN A 211
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
 0.59A 6g31B-2dh4A:
34.7		 6g31B-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 5 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
 0.97A 6g31C-2dh4A:
34.5		 6g31C-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		6 / 7 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
GLN A 211
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
 0.46A 6g31D-2dh4A:
34.2		 6g31D-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 4 LEU A  77
ASP A  80
ASP A  84
ARG A  89
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
 0.39A 6g31E-2dh4A:
27.6		 6g31E-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 5 ASP A  80
ASP A  84
ARG A  89
GLN A 147
GLN A 211
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
 0.76A 6g31F-2dh4A:
34.8		 6g31F-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		6 / 7 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
GLN A 211
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
 0.59A 6g31G-2dh4A:
33.4		 6g31G-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 7 ASP A  80
GLN A 147
LYS A 174
GLN A 211
TYR A 210
 MG  A 341 (-2.6A)
None
None
None
None
 1.18A 6g31G-2dh4A:
33.4		 6g31G-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 5 ASP A  80
ASP A  84
GLN A 147
GLN A 211
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
None
None
 0.37A 6g31H-2dh4A:
33.9		 6g31H-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 5 ASP A  80
ASP A  84
GLN A 147
LYS A 238
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
None
MG  A 341 ( 4.6A)
 0.88A 6g31H-2dh4A:
33.9		 6g31H-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G31_I_ZOLI401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 4 ASP A  80
ASP A  84
LYS A 174
GLN A 211
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
None
None
 0.74A 6g31I-2dh4A:
33.2		 6g31I-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 6 ASP A  84
ASP A  80
ARG A 154
GLN A 211
 MG  A 341 (-3.0A)
MG  A 341 (-2.6A)
None
None
 1.34A 6g31J-2dh4A:
35.0		 6g31J-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 6 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
 0.78A 6g31J-2dh4A:
35.0		 6g31J-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 6 LEU A  77
ASP A  80
ASP A  84
GLN A 147
GLN A 211
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
None
None
 0.43A 6g31J-2dh4A:
35.0		 6g31J-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G31_K_ZOLK401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 4 ASP A  80
ASP A  84
ARG A  89
GLN A 147
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
 0.54A 6g31K-2dh4A:
32.8		 6g31K-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 6 ASP A  80
ARG A  89
GLN A 147
LYS A 238
 MG  A 341 (-2.6A)
MG  A 341 ( 4.6A)
None
MG  A 341 ( 4.6A)
 1.24A 6g31L-2dh4A:
34.3		 6g31L-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		5 / 6 ASP A  80
ASP A  84
ARG A  89
GLN A 147
GLN A 211
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
 0.82A 6g31L-2dh4A:
34.3		 6g31L-2dh4A:
39.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 154
GLU A 236
ASP A  84
GLU A  83
 None
MG  A 341 ( 4.8A)
MG  A 341 (-3.0A)
None
 1.19A 6mn4A-2dh4A:
undetectable		 6mn4A-2dh4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 154
GLU A 236
ASP A  84
GLU A  83
 None
MG  A 341 ( 4.8A)
MG  A 341 (-3.0A)
None
 0.95A 6mn4B-2dh4A:
undetectable		 6mn4B-2dh4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 154
GLU A 236
ASP A  84
GLU A  83
 None
MG  A 341 ( 4.8A)
MG  A 341 (-3.0A)
None
 0.95A 6mn4C-2dh4A:
undetectable		 6mn4C-2dh4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 214
GLU A 236
ASP A  84
GLU A  83
 None
MG  A 341 ( 4.8A)
MG  A 341 (-3.0A)
None
 1.41A 6mn5A-2dh4A:
undetectable		 6mn5A-2dh4A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 154
GLU A 236
ASP A  84
GLU A  83
 None
MG  A 341 ( 4.8A)
MG  A 341 (-3.0A)
None
 1.01A 6mn5B-2dh4A:
undetectable		 6mn5B-2dh4A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 214
GLU A 236
ASP A  84
GLU A  83
 None
MG  A 341 ( 4.8A)
MG  A 341 (-3.0A)
None
 1.25A 6mn5B-2dh4A:
undetectable		 6mn5B-2dh4A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 214
GLU A 236
ASP A  84
GLU A  83
 None
MG  A 341 ( 4.8A)
MG  A 341 (-3.0A)
None
 1.33A 6mn5C-2dh4A:
undetectable		 6mn5C-2dh4A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 154
GLU A 236
ASP A  84
GLU A  83
 None
MG  A 341 ( 4.8A)
MG  A 341 (-3.0A)
None
 1.06A 6mn5D-2dh4A:
undetectable		 6mn5D-2dh4A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2dh4 YPL069C
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 214
GLU A 236
ASP A  84
GLU A  83
 None
MG  A 341 ( 4.8A)
MG  A 341 (-3.0A)
None
 1.33A 6mn5D-2dh4A:
undetectable		 6mn5D-2dh4A:
12.09