SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dh8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2dh8 DAZ-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A  67
TYR A  29
ILE A  80
GLY A  15
LEU A  12
 None
 1.02A 1eqhA-2dh8A:
undetectable		 1eqhA-2dh8A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2dh8 DAZ-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A  67
TYR A  29
ILE A  80
GLY A  15
LEU A  12
 None
 1.03A 1eqhB-2dh8A:
undetectable		 1eqhB-2dh8A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 2dh8 DAZ-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 10 ASP A  18
ILE A  80
GLY A  16
VAL A  40
ILE A  41
 None
 1.04A 3em4V-2dh8A:
undetectable		 3em4V-2dh8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 2dh8 DAZ-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 11 ASP A  76
LEU A  26
PHE A  30
LEU A  17
ILE A  80
 None
 1.19A 3o94A-2dh8A:
undetectable		 3o94A-2dh8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 2dh8 DAZ-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 11 ASP A  76
LEU A  26
PHE A  30
LEU A  17
ILE A  80
 None
 1.22A 3o94C-2dh8A:
undetectable		 3o94C-2dh8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 2dh8 DAZ-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 11 ASP A  76
LEU A  26
PHE A  30
LEU A  17
ILE A  80
 None
 1.21A 3o94D-2dh8A:
undetectable		 3o94D-2dh8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 2dh8 DAZ-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 VAL A  67
HIS A  73
SER A  70
THR A  66
 None
 1.08A 3tj7A-2dh8A:
undetectable
3tj7B-2dh8A:
undetectable		 3tj7A-2dh8A:
19.29
3tj7B-2dh8A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 2dh8 DAZ-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 VAL A  67
HIS A  73
SER A  70
THR A  66
 None
 1.10A 3tj7C-2dh8A:
undetectable
3tj7D-2dh8A:
undetectable		 3tj7C-2dh8A:
19.29
3tj7D-2dh8A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 2dh8 DAZ-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 VAL A  67
HIS A  73
SER A  70
THR A  66
 None
 1.07A 3tj7C-2dh8A:
undetectable
3tj7D-2dh8A:
undetectable		 3tj7C-2dh8A:
19.29
3tj7D-2dh8A:
19.29