SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dhb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2dhb HEMOGLOBIN (DEOXY)
(BETA CHAIN)
(Equus
caballus) 		5 / 12 LEU B  96
VAL B  98
SER B  44
VAL B  67
LEU B  28
 HEM  B 147 (-4.6A)
HEM  B 147 ( 4.8A)
HEM  B 147 (-2.8A)
HEM  B 147 (-3.9A)
None
 1.19A 1ie9A-2dhbB:
undetectable		 1ie9A-2dhbB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2dhb HEMOGLOBIN (DEOXY)
(BETA CHAIN)
(Equus
caballus) 		4 / 7 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 147 (-4.3A)
None
HEM  B 147 (-3.9A)
HEM  B 147 (-3.4A)
 0.89A 1lh6A-2dhbB:
13.4		 1lh6A-2dhbB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2dhb HEMOGLOBIN (DEOXY)
(BETA CHAIN)
(Equus
caballus) 		5 / 10 LEU B  68
VAL B 134
VAL B 109
TYR B 130
GLY B 107
 None
 1.43A 1lw0A-2dhbB:
undetectable		 1lw0A-2dhbB:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2dhb HEMOGLOBIN (DEOXY)
(BETA CHAIN)
(Equus
caballus) 		5 / 11 LEU B  68
VAL B 134
VAL B 109
TYR B 130
GLY B 107
 None
 1.47A 1lwcA-2dhbB:
undetectable		 1lwcA-2dhbB:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2dhb HEMOGLOBIN (DEOXY)
(BETA CHAIN)
(Equus
caballus) 		5 / 9 LEU B  68
VAL B 134
VAL B 109
TYR B 130
GLY B 107
 None
 1.39A 1vrtA-2dhbB:
undetectable		 1vrtA-2dhbB:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 2dhb HEMOGLOBIN (DEOXY)
(BETA CHAIN)
(Equus
caballus) 		5 / 12 HIS B  77
GLY B  72
GLY B  74
LEU B  12
ASP B  16
 None
 1.09A 1x1aA-2dhbB:
undetectable		 1x1aA-2dhbB:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 2dhb HEMOGLOBIN (DEOXY)
(BETA CHAIN)
(Equus
caballus) 		4 / 6 GLU B  26
ARG B  30
LEU B 112
ARG B 116
 None
 0.97A 5l6eA-2dhbB:
undetectable
5l6eB-2dhbB:
undetectable		 5l6eA-2dhbB:
25.86
5l6eB-2dhbB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2dhb HEMOGLOBIN (DEOXY)
(BETA CHAIN)
(Equus
caballus) 		4 / 6 ASP B  47
LEU B  48
GLY B  46
PHE B  45
 None
 1.05A 5nooC-2dhbB:
undetectable		 5nooC-2dhbB:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dhb HEMOGLOBIN (DEOXY)
(BETA CHAIN)
(Equus
caballus) 		4 / 4 VAL B 133
VAL B 134
TYR B 130
GLN B 127
 None
 1.33A 5qggA-2dhbB:
undetectable		 5qggA-2dhbB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dhb HEMOGLOBIN (DEOXY)
(BETA CHAIN)
(Equus
caballus) 		4 / 4 VAL B 133
VAL B 134
TYR B 130
GLN B 127
 None
 1.31A 5qgoA-2dhbB:
undetectable		 5qgoA-2dhbB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dhb HEMOGLOBIN (DEOXY)
(BETA CHAIN)
(Equus
caballus) 		4 / 4 VAL B 133
VAL B 134
TYR B 130
GLN B 127
 None
 1.32A 5qgpA-2dhbB:
undetectable		 5qgpA-2dhbB:
22.82