SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dhn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 2dhn 7,8-DIHYDRONEOPTERIN
ALDOLASE
(Staphylococcus
aureus) 		5 / 11 VAL A 112
GLY A 113
LEU A  73
GLY A 111
GLU A  22
 None
None
PH2  A 122 (-3.8A)
None
PH2  A 122 (-2.8A)
 1.03A 1iolA-2dhnA:
undetectable		 1iolA-2dhnA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2dhn 7,8-DIHYDRONEOPTERIN
ALDOLASE
(Staphylococcus
aureus) 		3 / 3 ILE A 116
ILE A 114
THR A  94
 None
 0.61A 1rg7A-2dhnA:
undetectable		 1rg7A-2dhnA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 2dhn 7,8-DIHYDRONEOPTERIN
ALDOLASE
(Staphylococcus
aureus) 		4 / 5 VAL A  37
VAL A  91
PHE A   6
ARG A 118
 None
 1.39A 3bjwH-2dhnA:
undetectable		 3bjwH-2dhnA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2dhn 7,8-DIHYDRONEOPTERIN
ALDOLASE
(Staphylococcus
aureus) 		5 / 12 LEU A  73
LEU A  76
ILE A  80
SER A  63
GLY A 113
 PH2  A 122 (-3.8A)
None
None
None
None
 1.26A 3lbdA-2dhnA:
undetectable		 3lbdA-2dhnA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2dhn 7,8-DIHYDRONEOPTERIN
ALDOLASE
(Staphylococcus
aureus) 		4 / 6 THR A  34
ARG A 118
ILE A  84
LEU A   7
 None
 0.94A 4acbC-2dhnA:
undetectable		 4acbC-2dhnA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2dhn 7,8-DIHYDRONEOPTERIN
ALDOLASE
(Staphylococcus
aureus) 		4 / 5 ILE A  64
VAL A  61
PHE A   6
HIS A  75
 None
 1.20A 4rzvA-2dhnA:
undetectable		 4rzvA-2dhnA:
20.28