SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dhr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2dhr FTSH
(Thermus
thermophilus) 		5 / 12 TYR A 530
LEU A 282
LEU A 279
VAL A 260
LEU A 193
 None
 1.39A 1ie9A-2dhrA:
undetectable		 1ie9A-2dhrA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2dhr FTSH
(Thermus
thermophilus) 		3 / 3 LEU A 569
VAL A 572
LEU A 576
 None
 0.41A 1mz9B-2dhrA:
undetectable		 1mz9B-2dhrA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2dhr FTSH
(Thermus
thermophilus) 		4 / 5 ASP A 388
LEU A 353
ALA A 372
LEU A 375
 None
 1.07A 1nh8A-2dhrA:
undetectable		 1nh8A-2dhrA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 2dhr FTSH
(Thermus
thermophilus) 		3 / 3 ASP A 287
PHE A 241
ASN A 280
 None
 0.62A 1sg9B-2dhrA:
undetectable		 1sg9B-2dhrA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 2dhr FTSH
(Thermus
thermophilus) 		3 / 3 GLU A 499
GLN A 468
ARG A 453
 None
 0.95A 2w3bB-2dhrA:
undetectable		 2w3bB-2dhrA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2dhr FTSH
(Thermus
thermophilus) 		5 / 12 LEU A 194
ALA A 164
ILE A 323
VAL A 158
ILE A 334
 None
None
None
None
ADP  A1001 (-3.7A)
 0.87A 3b2rA-2dhrA:
undetectable		 3b2rA-2dhrA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2dhr FTSH
(Thermus
thermophilus) 		5 / 11 LEU A 194
ALA A 164
ILE A 323
VAL A 158
ILE A 334
 None
None
None
None
ADP  A1001 (-3.7A)
 0.89A 3b2rB-2dhrA:
undetectable		 3b2rB-2dhrA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2dhr FTSH
(Thermus
thermophilus) 		5 / 12 PHE A 217
ILE A 251
PHE A 317
VAL A 260
ILE A 257
 None
 1.34A 3em0B-2dhrA:
undetectable		 3em0B-2dhrA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 2dhr FTSH
(Thermus
thermophilus) 		5 / 12 LEU A 569
VAL A 572
ALA A 423
GLU A 479
ALA A 478
 None
 1.18A 4fiaA-2dhrA:
undetectable		 4fiaA-2dhrA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2dhr FTSH
(Thermus
thermophilus) 		5 / 12 LEU A 569
VAL A 572
ALA A 423
GLU A 479
ALA A 478
 None
 1.18A 4fiaA-2dhrA:
undetectable		 4fiaA-2dhrA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2dhr FTSH
(Thermus
thermophilus) 		5 / 12 LEU A 312
GLU A 455
GLY A 448
GLU A 419
ARG A 503
 None
 1.23A 4retA-2dhrA:
undetectable		 4retA-2dhrA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2dhr FTSH
(Thermus
thermophilus) 		5 / 12 LEU A 312
GLU A 455
GLY A 448
GLU A 419
ARG A 503
 None
 1.23A 4retC-2dhrA:
undetectable		 4retC-2dhrA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2dhr FTSH
(Thermus
thermophilus) 		5 / 12 LEU A 283
LEU A 311
ALA A 299
VAL A 297
ILE A 257
 None
 1.10A 4x1yB-2dhrA:
undetectable		 4x1yB-2dhrA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2dhr FTSH
(Thermus
thermophilus) 		5 / 11 LEU A 283
LEU A 311
ALA A 299
VAL A 297
ILE A 257
 None
 1.10A 4x20D-2dhrA:
undetectable		 4x20D-2dhrA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 2dhr FTSH
(Thermus
thermophilus) 		3 / 3 LEU A 466
LEU A 465
TRP A 460
 None
 0.94A 5nwuA-2dhrA:
undetectable		 5nwuA-2dhrA:
5.33