SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dht'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 8 ARG A 215
GLY A 305
ILE A 308
ILE A 146
ILE A 147
 None
 1.37A 1hshD-2dhtA:
undetectable		 1hshD-2dhtA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		6 / 10 ARG A 115
ALA A 328
ILE A  35
GLY A  36
GLY A  32
ILE A  30
 None
 1.39A 1sdvA-2dhtA:
undetectable		 1sdvA-2dhtA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJY_H_BEZH306_0
(ANTIBODY 7A1 FAB')		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 4 ASN A 294
ALA A 292
ARG A 149
TYR A 299
 None
 1.35A 2ajyH-2dhtA:
0.0		 2ajyH-2dhtA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AK1_H_BEZH401_0
(ANTIBODY 7A1 FAB')		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 4 ASN A 294
ALA A 292
ARG A 149
TYR A 299
 None
 1.38A 2ak1H-2dhtA:
0.0		 2ak1H-2dhtA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 8 ALA A 233
PHE A 234
ALA A 238
LEU A 291
 None
 0.30A 2bxmA-2dhtA:
undetectable		 2bxmA-2dhtA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 10 SER A 195
ALA A 233
PHE A 234
ALA A 238
LEU A 291
 None
 0.78A 2bxqA-2dhtA:
undetectable		 2bxqA-2dhtA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		6 / 12 GLY A  36
GLY A  97
THR A  40
GLU A 327
THR A 395
ILE A  35
 None
 1.30A 2wa2B-2dhtA:
undetectable		 2wa2B-2dhtA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 SER A 301
HIS A 330
ASP A 383
 None
 0.73A 2wa2B-2dhtA:
undetectable		 2wa2B-2dhtA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		6 / 12 GLY A  32
GLY A  34
ILE A  39
ALA A  68
LEU A  99
VAL A 110
 None
 1.26A 2yqzB-2dhtA:
undetectable		 2yqzB-2dhtA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 5 LEU A 291
GLN A 200
THR A 203
HIS A 222
 None
 1.34A 3ce6B-2dhtA:
2.9		 3ce6B-2dhtA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A  97
GLY A  32
ILE A  39
ALA A 328
GLU A  65
 None
 1.17A 3ckkA-2dhtA:
undetectable		 3ckkA-2dhtA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 11 ILE A 124
ILE A 289
ALA A 210
GLU A 212
PRO A 126
 None
 0.96A 3tmzA-2dhtA:
undetectable		 3tmzA-2dhtA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 5 ILE A 290
ALA A 304
MET A 145
ARG A 125
 None
 1.25A 4ac9B-2dhtA:
undetectable
4ac9C-2dhtA:
3.0		 4ac9B-2dhtA:
24.81
4ac9C-2dhtA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 5 ILE A 290
ALA A 304
MET A 145
ARG A 125
 None
 1.28A 4acaB-2dhtA:
3.1
4acaC-2dhtA:
3.1		 4acaB-2dhtA:
24.81
4acaC-2dhtA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 7 ASP A 302
ASN A 123
GLU A 327
ASP A 298
 None
 1.22A 4fevB-2dhtA:
undetectable		 4fevB-2dhtA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 LYS A 198
TYR A 197
ARG A 201
 None
 1.42A 4gc9A-2dhtA:
undetectable		 4gc9A-2dhtA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 11 ILE A 220
LYS A 223
SER A 301
ILE A 300
THR A 199
 None
 1.26A 4qi9C-2dhtA:
undetectable		 4qi9C-2dhtA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A 356
LYS A 349
GLU A 352
 None
 0.74A 5d0yA-2dhtA:
undetectable		 5d0yA-2dhtA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 8 ILE A 384
ILE A 371
ALA A 374
TYR A 398
 None
 0.71A 5mvmA-2dhtA:
undetectable
5mvmB-2dhtA:
undetectable		 5mvmA-2dhtA:
11.73
5mvmB-2dhtA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 7 GLY A  17
LEU A 355
ILE A 319
GLY A 320
ILE A  27
 None
 1.36A 5vkqA-2dhtA:
undetectable
5vkqB-2dhtA:
undetectable		 5vkqA-2dhtA:
12.93
5vkqB-2dhtA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 8 ILE A  61
LEU A 355
LEU A 353
ALA A 350
 None
 0.83A 5y7pE-2dhtA:
undetectable		 5y7pE-2dhtA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 VAL A 295
TYR A 299
GLU A 231
 None
 0.79A 5zmqD-2dhtA:
undetectable
5zmqE-2dhtA:
undetectable		 5zmqD-2dhtA:
19.15
5zmqE-2dhtA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A  79
LYS A 109
ARG A 149
 None
 1.15A 6c06D-2dhtA:
undetectable		 6c06D-2dhtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A  97
VAL A 110
ILE A 311
LEU A 314
GLY A 346
 None
 0.95A 6c2mA-2dhtA:
undetectable		 6c2mA-2dhtA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A  97
VAL A 110
ARG A 149
ILE A 311
GLY A 346
 None
 1.08A 6c2mD-2dhtA:
undetectable		 6c2mD-2dhtA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 10 ASP A 119
GLY A 297
SER A 301
ALA A 304
ASN A 318
 None
 1.21A 6hu9L-2dhtA:
undetectable
6hu9P-2dhtA:
undetectable
6hu9T-2dhtA:
undetectable		 6hu9L-2dhtA:
22.75
6hu9P-2dhtA:
17.34
6hu9T-2dhtA:
9.88