SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dhz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 2dhz RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR (GEF)-LIKE 1
(Homo
sapiens) 		3 / 3 TYR A  21
VAL A 107
THR A  23
 None
 0.82A 2ygnA-2dhzA:
undetectable		 2ygnA-2dhzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2dhz RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR (GEF)-LIKE 1
(Homo
sapiens) 		5 / 9 SER A  62
SER A  85
ASN A  84
ILE A  83
GLY A 110
 None
 1.47A 4fxsA-2dhzA:
undetectable		 4fxsA-2dhzA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2dhz RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR (GEF)-LIKE 1
(Homo
sapiens) 		3 / 3 SER A  62
ALA A  60
VAL A  59
 None
 0.60A 4x20C-2dhzA:
undetectable		 4x20C-2dhzA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 2dhz RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR (GEF)-LIKE 1
(Homo
sapiens) 		3 / 3 PRO A  17
LEU A  58
SER A  94
 None
 0.82A 5fsaB-2dhzA:
undetectable		 5fsaB-2dhzA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 2dhz RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR (GEF)-LIKE 1
(Homo
sapiens) 		4 / 5 LEU A  81
VAL A  77
GLU A  74
LEU A  70
 None
 1.08A 5xooB-2dhzA:
undetectable		 5xooB-2dhzA:
24.39