SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2di4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG
(Aquifex
aeolicus) 		5 / 8 ILE A 522
LEU A 543
ILE A 547
GLU A 550
VAL A 508
 None
 1.31A 1linA-2di4A:
undetectable		 1linA-2di4A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG
(Aquifex
aeolicus) 		3 / 3 LEU A 573
VAL A 576
LEU A 580
 None
 0.43A 1mz9B-2di4A:
undetectable		 1mz9B-2di4A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG
(Aquifex
aeolicus) 		4 / 4 ALA A 478
VAL A 482
ALA A 479
HIS A 418
 None
None
None
HG  A1001 (-3.1A)
 1.08A 1q23A-2di4A:
undetectable		 1q23A-2di4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG
(Aquifex
aeolicus) 		4 / 4 ALA A 478
VAL A 482
ALA A 479
HIS A 418
 None
None
None
HG  A1001 (-3.1A)
 1.16A 1q23F-2di4A:
undetectable		 1q23F-2di4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG
(Aquifex
aeolicus) 		4 / 4 ALA A 478
VAL A 482
ALA A 479
HIS A 418
 None
None
None
HG  A1001 (-3.1A)
 1.03A 1q23K-2di4A:
undetectable		 1q23K-2di4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG
(Aquifex
aeolicus) 		4 / 7 GLY A 492
ALA A 493
ASP A 496
ILE A 417
 None
None
HG  A1001 (-2.3A)
None
 0.72A 3t3cA-2di4A:
undetectable		 3t3cA-2di4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG
(Aquifex
aeolicus) 		5 / 11 GLY A 492
ALA A 493
ASP A 496
GLY A 475
ILE A 417
 None
None
HG  A1001 (-2.3A)
None
None
 0.81A 3ufnA-2di4A:
undetectable		 3ufnA-2di4A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG
(Aquifex
aeolicus) 		3 / 3 TYR A 467
GLU A 560
TYR A 559
 None
 1.01A 3ug8A-2di4A:
undetectable		 3ug8A-2di4A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG
(Aquifex
aeolicus) 		4 / 7 GLU A 480
ILE A 489
GLU A 481
TYR A 559
 None
 1.03A 4a97D-2di4A:
undetectable		 4a97D-2di4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG
(Aquifex
aeolicus) 		4 / 5 GLY A 476
GLY A 475
MET A 425
GLU A 480
 None
 1.09A 4fglC-2di4A:
undetectable		 4fglC-2di4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG
(Aquifex
aeolicus) 		3 / 3 GLU A 567
ILE A 417
ALA A 562
 None
 0.60A 4wnwB-2di4A:
1.8		 4wnwB-2di4A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG
(Aquifex
aeolicus) 		4 / 7 GLY A 492
ALA A 493
ASP A 496
ILE A 417
 None
None
HG  A1001 (-2.3A)
None
 0.67A 5kqyB-2di4A:
undetectable		 5kqyB-2di4A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG
(Aquifex
aeolicus) 		4 / 8 GLY A 492
ALA A 493
ASP A 496
ILE A 417
 None
None
HG  A1001 (-2.3A)
None
 0.67A 5kr1B-2di4A:
undetectable		 5kr1B-2di4A:
16.97