SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dis'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 2dis UNNAMED PROTEIN
PRODUCT
(Homo
sapiens) 		5 / 12 TYR A  59
ALA A  55
ILE A  40
ARG A  22
ILE A  84
 None
 1.08A 1ve3B-2disA:
undetectable		 1ve3B-2disA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2dis UNNAMED PROTEIN
PRODUCT
(Homo
sapiens) 		5 / 8 ILE A  16
ILE A  13
ILE A  77
VAL A  57
ALA A  68
 None
 1.36A 2nniA-2disA:
undetectable		 2nniA-2disA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 2dis UNNAMED PROTEIN
PRODUCT
(Homo
sapiens) 		4 / 6 VAL A  32
LEU A  79
ILE A  84
VAL A  57
 None
 0.95A 4a9kA-2disA:
undetectable		 4a9kA-2disA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 2dis UNNAMED PROTEIN
PRODUCT
(Homo
sapiens) 		5 / 9 VAL A  32
GLU A  27
ILE A  29
GLY A  35
ALA A  68
 None
 1.16A 4fwdA-2disA:
undetectable		 4fwdA-2disA:
9.67