SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dit'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DIT_P_2PPP1_1 (ALPHA-THROMBIN PEPTIDE INHIBITOR CVS995)	2dit	HIV TAT SPECIFIC FACTOR 1 VARIANT (Homo sapiens)	4 / 6	LEU A 58 ILE A 20 GLU A 46 ASP A 42	None	1.14A	1ditH-2ditA: undetectable 1ditP-2ditA: undetectable	1ditH-2ditA: 20.61 1ditP-2ditA: 23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XZX_X_T3X500_1 (THYROID HORMONE RECEPTOR BETA-1)	2dit	HIV TAT SPECIFIC FACTOR 1 VARIANT (Homo sapiens)	5 / 12	ILE A 19 ILE A 20 ALA A 96 LEU A 56 ILE A 53	None	1.23A	1xzxX-2ditA: undetectable	1xzxX-2ditA: 15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GWS_X_T3X500_1 (THYROID HORMONE RECEPTOR BETA)	2dit	HIV TAT SPECIFIC FACTOR 1 VARIANT (Homo sapiens)	5 / 12	ILE A 19 ILE A 20 ALA A 96 ALA A 77 PHE A 89	None	1.08A	3gwsX-2ditA: undetectable	3gwsX-2ditA: 14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TJ7_A_ACTA609_0 (GBAA_1210 PROTEIN)	2dit	HIV TAT SPECIFIC FACTOR 1 VARIANT (Homo sapiens)	3 / 3	LYS A 21 VAL A 66 HIS A 62	None	0.94A	3tj7A-2ditA: undetectable	3tj7A-2ditA: 14.36

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DIT_P_2PPP1_1","ALPHA-THROMBIN;PEPTIDE INHIBITOR CVS995","2dit","HIV TAT SPECIFIC FACTOR 1 VARIANT","Homo sapiens",4,"LEU A  58;ILE A  20;GLU A  46;ASP A  42","None","1.14A","1ditH-2ditA:undetectable;1ditP-2ditA:undetectable","1ditH-2ditA:20.61;1ditP-2ditA:23.26"],["1XZX_X_T3X500_1","THYROID HORMONE RECEPTOR BETA-1","2dit","HIV TAT SPECIFIC FACTOR 1 VARIANT","Homo sapiens",5,"ILE A  19;ILE A  20;ALA A  96;LEU A  56;ILE A  53","None","1.23A","1xzxX-2ditA:undetectable","1xzxX-2ditA:15.99"],["3GWS_X_T3X500_1","THYROID HORMONE RECEPTOR BETA","2dit","HIV TAT SPECIFIC FACTOR 1 VARIANT","Homo sapiens",5,"ILE A  19;ILE A  20;ALA A  96;ALA A  77;PHE A  89","None","1.08A","3gwsX-2ditA:undetectable","3gwsX-2ditA:14.86"],["3TJ7_A_ACTA609_0","GBAA_1210 PROTEIN","2dit","HIV TAT SPECIFIC FACTOR 1 VARIANT","Homo sapiens",3,"LYS A  21;VAL A  66;HIS A  62","None","0.94A","3tj7A-2ditA:undetectable","3tj7A-2ditA:14.36"]]