SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2diw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 2diw PUTATIVE RNA-BINDING
PROTEIN 16
(Homo
sapiens) 		5 / 12 LEU A 140
MET A 143
ARG A 110
ILE A 101
TRP A 126
 None
 1.41A 1ot7B-2diwA:
0.0		 1ot7B-2diwA:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 2diw PUTATIVE RNA-BINDING
PROTEIN 16
(Homo
sapiens) 		4 / 5 PRO A  29
ILE A  30
PRO A  70
TYR A  73
 None
 0.32A 3d9lA-2diwA:
23.6
3d9lY-2diwA:
undetectable		 3d9lA-2diwA:
95.10
3d9lY-2diwA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2diw PUTATIVE RNA-BINDING
PROTEIN 16
(Homo
sapiens) 		4 / 6 ILE A  38
GLU A  19
ALA A  42
ASN A  17
 None
 1.06A 3pgyA-2diwA:
undetectable
3pgyB-2diwA:
undetectable		 3pgyA-2diwA:
14.94
3pgyB-2diwA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 2diw PUTATIVE RNA-BINDING
PROTEIN 16
(Homo
sapiens) 		4 / 6 PRO A  70
GLY A  71
LEU A 108
GLU A  66
 None
 1.02A 3zqtA-2diwA:
undetectable		 3zqtA-2diwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2diw PUTATIVE RNA-BINDING
PROTEIN 16
(Homo
sapiens) 		4 / 6 VAL A 122
LEU A 123
LEU A 108
PHE A  16
 None
 0.92A 4o1zA-2diwA:
undetectable		 4o1zA-2diwA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2diw PUTATIVE RNA-BINDING
PROTEIN 16
(Homo
sapiens) 		3 / 3 PRO A 139
LEU A 140
GLN A 106
 None
 0.48A 4pevB-2diwA:
undetectable		 4pevB-2diwA:
15.17