SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dj6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_A_H4BA1003_1
(HYPOTHETICAL PROTEIN
PH0634)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		6 / 10 HIS A  15
HIS A  29
THR A  76
THR A  77
GLU A  78
GLU A 105
 HIS  A  15 ( 1.0A)
HIS  A  29 ( 1.0A)
THR  A  76 ( 0.8A)
THR  A  77 ( 0.8A)
GLU  A  78 ( 0.5A)
GLU  A 105 ( 0.6A)
 0.32A 2dttA-2dj6A:
22.2
2dttC-2dj6A:
21.8		 2dttA-2dj6A:
100.00
2dttC-2dj6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_D_H4BD1006_1
(HYPOTHETICAL PROTEIN
PH0634)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		6 / 10 HIS A  15
HIS A  29
THR A  76
THR A  77
GLU A  78
GLU A 105
 HIS  A  15 ( 1.0A)
HIS  A  29 ( 1.0A)
THR  A  76 ( 0.8A)
THR  A  77 ( 0.8A)
GLU  A  78 ( 0.5A)
GLU  A 105 ( 0.6A)
 0.56A 2dttD-2dj6A:
21.5
2dttF-2dj6A:
21.7		 2dttD-2dj6A:
100.00
2dttF-2dj6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		6 / 11 HIS A  15
HIS A  29
THR A  76
THR A  77
GLU A  78
GLU A 105
 HIS  A  15 ( 1.0A)
HIS  A  29 ( 1.0A)
THR  A  76 ( 0.8A)
THR  A  77 ( 0.8A)
GLU  A  78 ( 0.5A)
GLU  A 105 ( 0.6A)
 0.46A 2dttD-2dj6A:
21.5
2dttE-2dj6A:
20.6		 2dttD-2dj6A:
100.00
2dttE-2dj6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_F_H4BF1005_1
(HYPOTHETICAL PROTEIN
PH0634)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		5 / 9 HIS A  29
THR A  76
THR A  77
GLU A  78
GLU A 105
 HIS  A  29 ( 1.0A)
THR  A  76 ( 0.8A)
THR  A  77 ( 0.8A)
GLU  A  78 ( 0.5A)
GLU  A 105 ( 0.6A)
 0.52A 2dttE-2dj6A:
20.6
2dttF-2dj6A:
21.7		 2dttE-2dj6A:
100.00
2dttF-2dj6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		4 / 8 LEU A  63
VAL A 101
LEU A 103
VAL A  35
 LEU  A  63 ( 0.5A)
VAL  A 101 ( 0.6A)
LEU  A 103 ( 0.6A)
VAL  A  35 ( 0.6A)
 0.87A 2zujA-2dj6A:
undetectable		 2zujA-2dj6A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		4 / 7 ARG A  87
ILE A  88
LEU A 103
ARG A  66
 ARG  A  87 ( 0.6A)
ILE  A  88 ( 0.7A)
LEU  A 103 ( 0.6A)
ARG  A  66 ( 0.6A)
 0.95A 3nxuA-2dj6A:
undetectable		 3nxuA-2dj6A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		4 / 5 LEU A  63
ALA A  13
PHE A  31
ASN A  69
 LEU  A  63 ( 0.5A)
ALA  A  13 ( 0.0A)
PHE  A  31 ( 1.3A)
ASN  A  69 ( 0.6A)
 1.44A 3uq6A-2dj6A:
undetectable		 3uq6A-2dj6A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		4 / 4 LEU A  63
ALA A  13
PHE A  31
ASN A  69
 LEU  A  63 ( 0.5A)
ALA  A  13 ( 0.0A)
PHE  A  31 ( 1.3A)
ASN  A  69 ( 0.6A)
 1.49A 3vaqA-2dj6A:
undetectable		 3vaqA-2dj6A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		5 / 12 LEU A  52
VAL A  56
LEU A 103
ILE A  88
ILE A  37
 LEU  A  52 ( 0.6A)
VAL  A  56 ( 0.6A)
LEU  A 103 ( 0.6A)
ILE  A  88 ( 0.7A)
ILE  A  37 ( 0.7A)
 1.05A 4ltwA-2dj6A:
undetectable		 4ltwA-2dj6A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		3 / 3 LYS A  27
HIS A  15
HIS A  29
 HIS  A  27 ( 0.0A)
HIS  A  15 ( 1.0A)
HIS  A  29 ( 1.0A)
 1.08A 5oexA-2dj6A:
undetectable		 5oexA-2dj6A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		3 / 3 LYS A  27
HIS A  15
HIS A  29
 HIS  A  27 ( 0.0A)
HIS  A  15 ( 1.0A)
HIS  A  29 ( 1.0A)
 1.10A 5oexB-2dj6A:
undetectable		 5oexB-2dj6A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		3 / 3 LYS A  27
HIS A  15
HIS A  29
 HIS  A  27 ( 0.0A)
HIS  A  15 ( 1.0A)
HIS  A  29 ( 1.0A)
 1.07A 5oexC-2dj6A:
undetectable		 5oexC-2dj6A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		3 / 3 LYS A  27
HIS A  15
HIS A  29
 HIS  A  27 ( 0.0A)
HIS  A  15 ( 1.0A)
HIS  A  29 ( 1.0A)
 1.03A 5oexD-2dj6A:
undetectable		 5oexD-2dj6A:
16.08