SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2djz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		4 / 6 ASP A 218
LEU A 217
GLY A 202
ARG A 191
 None
 0.85A 1mt1G-2djzA:
undetectable
1mt1J-2djzA:
undetectable		 1mt1G-2djzA:
12.34
1mt1J-2djzA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		4 / 7 ARG A 191
ASP A 218
LEU A 217
GLY A 202
 None
 0.83A 1mt1H-2djzA:
0.6
1mt1K-2djzA:
undetectable		 1mt1H-2djzA:
16.60
1mt1K-2djzA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 153
VAL A 156
LEU A 160
 None
 0.24A 1mz9B-2djzA:
undetectable		 1mz9B-2djzA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		4 / 7 ARG A 191
ASP A 218
LEU A 217
GLY A 202
 None
 0.86A 1n13D-2djzA:
0.3
1n13E-2djzA:
undetectable		 1n13D-2djzA:
16.60
1n13E-2djzA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		4 / 8 ASP A 218
LEU A 217
GLY A 202
ARG A 191
 None
 0.89A 1n13A-2djzA:
undetectable
1n13F-2djzA:
0.7		 1n13A-2djzA:
12.34
1n13F-2djzA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		4 / 6 ARG A 191
ASP A 218
LEU A 217
GLY A 202
 None
 0.84A 1n13H-2djzA:
0.6
1n13K-2djzA:
undetectable		 1n13H-2djzA:
16.60
1n13K-2djzA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		4 / 7 ASP A 218
LEU A 217
GLY A 202
ARG A 191
 None
 0.86A 1n13G-2djzA:
undetectable
1n13J-2djzA:
0.6		 1n13G-2djzA:
12.34
1n13J-2djzA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		5 / 9 VAL A 182
LEU A 181
LEU A 164
GLY A  82
ALA A  83
 None
 1.21A 1pxxB-2djzA:
2.4		 1pxxB-2djzA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		5 / 10 VAL A 182
LEU A 181
LEU A 164
GLY A  82
ALA A  83
 None
 1.22A 1pxxD-2djzA:
2.3		 1pxxD-2djzA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		4 / 5 ILE A  99
ILE A  95
MET A 143
LEU A 126
 None
 0.79A 1zgyA-2djzA:
undetectable		 1zgyA-2djzA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A  14
GLY A  10
ILE A   9
ALA A  26
ILE A  37
 None
 1.01A 2b60B-2djzA:
undetectable		 2b60B-2djzA:
21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		7 / 7 ARG A  51
TRP A  53
GLU A  54
ALA A 111
ASN A 131
PRO A 137
ALA A 140
 BT5  A1301 (-4.0A)
BT5  A1301 (-3.8A)
None
BT5  A1301 ( 3.8A)
BT5  A1301 (-3.0A)
BT5  A1301 (-4.6A)
BT5  A1301 (-3.4A)
 0.57A 2ejfA-2djzA:
39.1		 2ejfA-2djzA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		4 / 6 ARG A  48
TRP A  53
ASN A 131
ALA A 111
 None
BT5  A1301 (-3.8A)
BT5  A1301 (-3.0A)
BT5  A1301 ( 3.8A)
 1.11A 2ejfB-2djzA:
40.1		 2ejfB-2djzA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		4 / 6 ARG A  51
TRP A  53
ASN A 131
ALA A 111
 BT5  A1301 (-4.0A)
BT5  A1301 (-3.8A)
BT5  A1301 (-3.0A)
BT5  A1301 ( 3.8A)
 1.25A 2ejfB-2djzA:
40.1		 2ejfB-2djzA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		6 / 6 ARG A  51
TRP A  53
GLU A  54
ASN A 131
PRO A 137
ALA A 140
 BT5  A1301 (-4.0A)
BT5  A1301 (-3.8A)
None
BT5  A1301 (-3.0A)
BT5  A1301 (-4.6A)
BT5  A1301 (-3.4A)
 0.44A 2ejfB-2djzA:
40.1		 2ejfB-2djzA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		4 / 7 ARG A  48
TRP A  53
ASN A 131
ALA A 111
 None
BT5  A1301 (-3.8A)
BT5  A1301 (-3.0A)
BT5  A1301 ( 3.8A)
 1.18A 2ejgA-2djzA:
38.4		 2ejgA-2djzA:
99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		6 / 7 ARG A  51
TRP A  53
GLU A  54
ASN A 131
PRO A 137
ALA A 140
 BT5  A1301 (-4.0A)
BT5  A1301 (-3.8A)
None
BT5  A1301 (-3.0A)
BT5  A1301 (-4.6A)
BT5  A1301 (-3.4A)
 0.50A 2ejgA-2djzA:
38.4		 2ejgA-2djzA:
99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		5 / 7 TRP A  53
GLU A  54
ASN A 131
PRO A 137
ALA A 140
 BT5  A1301 (-3.8A)
None
BT5  A1301 (-3.0A)
BT5  A1301 (-4.6A)
BT5  A1301 (-3.4A)
 0.28A 2ejgB-2djzA:
39.2		 2ejgB-2djzA:
99.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		4 / 7 ARG A 191
ASP A 218
LEU A 217
GLY A 202
 None
 0.85A 2qqcD-2djzA:
0.6
2qqcE-2djzA:
undetectable		 2qqcD-2djzA:
17.57
2qqcE-2djzA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		4 / 8 ARG A 191
ASP A 218
LEU A 217
GLY A 202
 None
 0.81A 2qqcH-2djzA:
0.6
2qqcK-2djzA:
undetectable		 2qqcH-2djzA:
17.57
2qqcK-2djzA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		4 / 8 ARG A 191
ASP A 218
LEU A 217
GLY A 202
 None
 0.84A 2qqdB-2djzA:
0.7
2qqdC-2djzA:
undetectable		 2qqdB-2djzA:
17.57
2qqdC-2djzA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		6 / 7 TRP A  53
GLU A  54
ALA A 111
ASN A 131
PRO A 137
ALA A 140
 BT5  A1301 (-3.8A)
None
BT5  A1301 ( 3.8A)
BT5  A1301 (-3.0A)
BT5  A1301 (-4.6A)
BT5  A1301 (-3.4A)
 0.10A 2zgwA-2djzA:
43.5		 2zgwA-2djzA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		6 / 6 TRP A  53
GLU A  54
ALA A 111
ASN A 131
PRO A 137
ALA A 140
 BT5  A1301 (-3.8A)
None
BT5  A1301 ( 3.8A)
BT5  A1301 (-3.0A)
BT5  A1301 (-4.6A)
BT5  A1301 (-3.4A)
 0.17A 2zgwB-2djzA:
41.2		 2zgwB-2djzA:
99.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		4 / 8 ALA A  83
VAL A  86
LEU A  90
LEU A 106
 None
 0.82A 3roxA-2djzA:
undetectable		 3roxA-2djzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		5 / 9 ALA A 113
ASP A 104
GLY A  85
ILE A  95
ILE A 112
 None
BT5  A1301 (-3.3A)
None
None
None
 0.97A 3s43A-2djzA:
undetectable		 3s43A-2djzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A 182
LEU A 181
LEU A 164
GLY A  82
ALA A  83
 None
 1.09A 4otyA-2djzA:
2.0		 4otyA-2djzA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		6 / 12 GLY A 129
ALA A 113
ASP A 104
GLY A  85
ILE A  95
ILE A 112
 BT5  A1301 (-3.7A)
None
BT5  A1301 (-3.3A)
None
None
None
 1.23A 5e5jB-2djzA:
undetectable		 5e5jB-2djzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		4 / 4 GLY A  85
ARG A 166
ASN A 163
LEU A 164
 None
 1.24A 6b58A-2djzA:
undetectable		 6b58A-2djzA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 130
VAL A  87
VAL A 115
ALA A  83
LEU A  90
 None
 1.11A 6czmA-2djzA:
2.9
6czmC-2djzA:
undetectable		 6czmA-2djzA:
22.80
6czmC-2djzA:
22.80