SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dk8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UPF_A_URFA999_1 (URACIL PHOSPHORIBOSYLTRANSF ERASE)	2dk8	DNA-DIRECTED RNA POLYMERASE III 39 KDA POLYPEPTIDE (Mus musculus)	4 / 5	ALA A 50 TYR A 71 ILE A 19 ASP A 32	None	1.15A	1upfA-2dk8A: undetectable	1upfA-2dk8A: 15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UPF_C_URFC999_1 (URACIL PHOSPHORIBOSYLTRANSF ERASE)	2dk8	DNA-DIRECTED RNA POLYMERASE III 39 KDA POLYPEPTIDE (Mus musculus)	4 / 5	ALA A 50 TYR A 71 ILE A 19 ASP A 32	None	1.17A	1upfC-2dk8A: undetectable	1upfC-2dk8A: 15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BU8_A_TF4A1379_1 (PYRUVATE DEHYDROGENASE KINASE ISOENZYME 2)	2dk8	DNA-DIRECTED RNA POLYMERASE III 39 KDA POLYPEPTIDE (Mus musculus)	5 / 8	LEU A 60 ILE A 30 ILE A 19 ARG A 18 ILE A 35	None	1.03A	2bu8A-2dk8A: undetectable	2bu8A-2dk8A: 12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_E_PCFE202_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 5A, MITOCHONDRIAL CYTOCHROME C OXIDASE SUBUNIT 1)	2dk8	DNA-DIRECTED RNA POLYMERASE III 39 KDA POLYPEPTIDE (Mus musculus)	4 / 8	TYR A 71 ILE A 35 ALA A 48 VAL A 49	None	1.03A	6hu9a-2dk8A: undetectable 6hu9e-2dk8A: undetectable	6hu9a-2dk8A: 10.43 6hu9e-2dk8A: 17.27

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1UPF_A_URFA999_1","URACIL PHOSPHORIBOSYLTRANSFERASE","2dk8","DNA-DIRECTED RNA POLYMERASE III 39 KDA POLYPEPTIDE","Mus musculus",4,"ALA A  50;TYR A  71;ILE A  19;ASP A  32","None","1.15A","1upfA-2dk8A:undetectable","1upfA-2dk8A:15.70"],["1UPF_C_URFC999_1","URACIL PHOSPHORIBOSYLTRANSFERASE","2dk8","DNA-DIRECTED RNA POLYMERASE III 39 KDA POLYPEPTIDE","Mus musculus",4,"ALA A  50;TYR A  71;ILE A  19;ASP A  32","None","1.17A","1upfC-2dk8A:undetectable","1upfC-2dk8A:15.70"],["2BU8_A_TF4A1379_1","PYRUVATE DEHYDROGENASE KINASE ISOENZYME 2","2dk8","DNA-DIRECTED RNA POLYMERASE III 39 KDA POLYPEPTIDE","Mus musculus",5,"LEU A  60;ILE A  30;ILE A  19;ARG A  18;ILE A  35","None","1.03A","2bu8A-2dk8A:undetectable","2bu8A-2dk8A:12.56"],["6HU9_E_PCFE202_0","CYTOCHROME C OXIDASE POLYPEPTIDE 5A, MITOCHONDRIAL;CYTOCHROME C OXIDASE SUBUNIT 1","2dk8","DNA-DIRECTED RNA POLYMERASE III 39 KDA POLYPEPTIDE","Mus musculus",4,"TYR A  71;ILE A  35;ALA A  48;VAL A  49","None","1.03A","6hu9a-2dk8A:undetectable;6hu9e-2dk8A:undetectable","6hu9a-2dk8A:10.43;6hu9e-2dk8A:17.27"]]