SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dkh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 12 LEU A 388
ALA A 378
GLY A 497
LEU A 372
PHE A 636
 None
 1.26A 1brpA-2dkhA:
undetectable		 1brpA-2dkhA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 8 LEU A 372
ALA A  43
GLY A  39
ILE A  61
PHE A 345
 None
FAD  A 640 (-3.0A)
FAD  A 640 (-3.3A)
None
None
 1.04A 1d4sB-2dkhA:
undetectable		 1d4sB-2dkhA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 8 ILE A 601
VAL A 559
GLY A 606
LEU A 623
 None
 0.93A 1dzmA-2dkhA:
undetectable		 1dzmA-2dkhA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 10 ASP A  75
GLY A  76
ILE A 260
ARG A 269
TYR A 271
 3HB  A 641 (-2.8A)
3HB  A 641 (-3.3A)
3HB  A 641 (-4.2A)
FAD  A 640 (-3.8A)
3HB  A 641 ( 4.0A)
 0.31A 1fohA-2dkhA:
38.4		 1fohA-2dkhA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 10 ASP A  75
GLY A  76
ILE A 260
ARG A 269
TYR A 271
 3HB  A 641 (-2.8A)
3HB  A 641 (-3.3A)
3HB  A 641 (-4.2A)
FAD  A 640 (-3.8A)
3HB  A 641 ( 4.0A)
 0.29A 1fohB-2dkhA:
38.3		 1fohB-2dkhA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 10 ASP A  75
GLY A  76
ILE A 260
ARG A 269
TYR A 271
 3HB  A 641 (-2.8A)
3HB  A 641 (-3.3A)
3HB  A 641 (-4.2A)
FAD  A 640 (-3.8A)
3HB  A 641 ( 4.0A)
 0.28A 1fohC-2dkhA:
37.5		 1fohC-2dkhA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 10 ASP A  75
GLY A  76
ILE A 260
ARG A 269
TYR A 271
 3HB  A 641 (-2.8A)
3HB  A 641 (-3.3A)
3HB  A 641 (-4.2A)
FAD  A 640 (-3.8A)
3HB  A 641 ( 4.0A)
 0.26A 1fohD-2dkhA:
37.7		 1fohD-2dkhA:
36.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 12 LEU A 454
SER A 452
SER A 635
VAL A 610
LEU A 621
 None
 1.33A 1ie9A-2dkhA:
undetectable		 1ie9A-2dkhA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 8 THR A 442
VAL A 104
ASP A 125
VAL A 123
 None
 0.88A 1iwiA-2dkhA:
undetectable		 1iwiA-2dkhA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OXR_A_AINA141_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 4 LEU A 489
GLY A 493
ASP A 547
TYR A 502
 None
 1.26A 1oxrA-2dkhA:
undetectable		 1oxrA-2dkhA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 12 ALA A 550
PHE A 552
ALA A 505
ALA A 503
LEU A 629
 None
 1.04A 1rbpA-2dkhA:
undetectable		 1rbpA-2dkhA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 9 VAL A 610
LEU A 501
PHE A 636
MET A 637
LEU A 629
 None
 1.26A 1wrkA-2dkhA:
undetectable
1wrkB-2dkhA:
undetectable		 1wrkA-2dkhA:
10.22
1wrkB-2dkhA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 7 PHE A 633
LEU A 621
PHE A 636
SER A 452
 None
 1.11A 1wrlA-2dkhA:
undetectable
1wrlB-2dkhA:
undetectable		 1wrlA-2dkhA:
10.22
1wrlB-2dkhA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 5 PHE A 633
LEU A 621
PHE A 636
SER A 452
 None
 1.25A 1wrlC-2dkhA:
undetectable		 1wrlC-2dkhA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 7 PHE A 633
LEU A 621
PHE A 636
SER A 452
 None
 1.08A 1wrlE-2dkhA:
undetectable		 1wrlE-2dkhA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 8 TYR A 202
PHE A 345
HIS A 390
LEU A 341
 None
 1.07A 1x8vA-2dkhA:
0.4		 1x8vA-2dkhA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 6 LEU A 567
LEU A 568
LEU A 518
LEU A 520
 None
 0.85A 2ab2A-2dkhA:
undetectable		 2ab2A-2dkhA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 5 LEU A 567
LEU A 568
LEU A 518
LEU A 520
 None
 0.81A 2ab2B-2dkhA:
undetectable		 2ab2B-2dkhA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		6 / 12 ALA A 350
ASP A 349
GLY A  41
GLY A  44
ILE A  37
VAL A 166
 None
FAD  A 640 (-2.9A)
FAD  A 640 (-3.6A)
None
None
FAD  A 640 (-4.1A)
 1.45A 2fxeA-2dkhA:
undetectable		 2fxeA-2dkhA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 7 THR A 442
VAL A 104
ASP A 125
VAL A 123
 None
 0.86A 2qbnA-2dkhA:
undetectable		 2qbnA-2dkhA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 6 ILE A 545
ARG A 498
PRO A 155
SER A  19
 None
 1.09A 2qd3B-2dkhA:
0.0		 2qd3B-2dkhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		3 / 3 LEU A 564
PRO A 565
LEU A 568
 None
 0.49A 2qd5B-2dkhA:
undetectable		 2qd5B-2dkhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 12 HIS A 144
ALA A  43
GLY A 205
VAL A  38
GLY A  39
 None
FAD  A 640 (-3.0A)
None
None
FAD  A 640 (-3.3A)
 1.05A 3f8wC-2dkhA:
undetectable		 3f8wC-2dkhA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 7 TYR A 392
LEU A 376
SER A 369
ASN A 371
 None
 0.96A 3lm8A-2dkhA:
undetectable
3lm8C-2dkhA:
undetectable		 3lm8A-2dkhA:
16.69
3lm8C-2dkhA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 7 TYR A 392
LEU A 376
SER A 369
ASN A 371
 None
 1.04A 3lm8B-2dkhA:
undetectable
3lm8D-2dkhA:
undetectable		 3lm8B-2dkhA:
16.69
3lm8D-2dkhA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 7 TYR A 392
LEU A 389
LEU A 376
THR A  46
 None
 1.02A 3lm8B-2dkhA:
undetectable
3lm8D-2dkhA:
undetectable		 3lm8B-2dkhA:
16.69
3lm8D-2dkhA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 12 PHE A 370
PHE A  90
ALA A  91
ILE A  77
ALA A  78
 None
 1.07A 3nxuA-2dkhA:
undetectable		 3nxuA-2dkhA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 12 PHE A 370
PHE A  90
ALA A  91
ILE A  77
ALA A  78
 None
 1.10A 3nxuB-2dkhA:
undetectable		 3nxuB-2dkhA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 12 GLN A 367
GLY A 446
GLY A 444
GLN A 360
TYR A 449
 None
 1.24A 3t7sC-2dkhA:
undetectable		 3t7sC-2dkhA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 8 VAL A 330
HIS A 390
PHE A 345
PRO A 179
 None
 1.04A 3v35A-2dkhA:
undetectable		 3v35A-2dkhA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 7 PHE A 467
VAL A 611
GLY A 490
PHE A 504
 None
 0.75A 4ejjB-2dkhA:
undetectable		 4ejjB-2dkhA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		3 / 3 ASP A 243
TYR A 246
TRP A 107
 None
 1.04A 4p7nA-2dkhA:
undetectable		 4p7nA-2dkhA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 12 VAL A 213
SER A 211
ILE A 346
ARG A 214
VAL A 171
 None
 1.39A 4rujA-2dkhA:
undetectable		 4rujA-2dkhA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 7 ILE A  37
GLU A  63
GLY A  41
GLY A  44
 None
FAD  A 640 (-2.7A)
FAD  A 640 (-3.6A)
None
 0.87A 5a06A-2dkhA:
undetectable		 5a06A-2dkhA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 7 ILE A  37
GLU A  63
GLY A  41
GLY A  44
 None
FAD  A 640 (-2.7A)
FAD  A 640 (-3.6A)
None
 0.85A 5a06C-2dkhA:
3.0		 5a06C-2dkhA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 7 ILE A  37
GLU A  63
GLY A  41
GLY A  44
 None
FAD  A 640 (-2.7A)
FAD  A 640 (-3.6A)
None
 0.86A 5a06F-2dkhA:
3.2		 5a06F-2dkhA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 5 ILE A 259
LYS A 108
ILE A 117
VAL A 300
 None
 0.94A 5jmnA-2dkhA:
undetectable		 5jmnA-2dkhA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 7 LEU A 306
ILE A 288
TRP A 314
MET A 233
 None
 1.37A 5ljcA-2dkhA:
undetectable		 5ljcA-2dkhA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 12 ILE A 260
LEU A 258
GLY A  76
GLY A 361
HIS A 135
 3HB  A 641 (-4.2A)
None
3HB  A 641 (-3.3A)
FAD  A 640 (-3.6A)
3HB  A 641 (-3.8A)
 1.09A 5nnaA-2dkhA:
undetectable		 5nnaA-2dkhA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 12 ILE A 260
LEU A 258
GLY A  76
GLY A 361
HIS A 135
 3HB  A 641 (-4.2A)
None
3HB  A 641 (-3.3A)
FAD  A 640 (-3.6A)
3HB  A 641 (-3.8A)
 1.10A 5nnaC-2dkhA:
undetectable		 5nnaC-2dkhA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 12 ILE A 260
LEU A 258
GLY A  76
GLY A 361
HIS A 135
 3HB  A 641 (-4.2A)
None
3HB  A 641 (-3.3A)
FAD  A 640 (-3.6A)
3HB  A 641 (-3.8A)
 1.06A 5nnaD-2dkhA:
undetectable		 5nnaD-2dkhA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		4 / 8 ARG A 343
ILE A  37
LEU A 372
GLY A 373
 None
 0.90A 5nooD-2dkhA:
undetectable		 5nooD-2dkhA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 12 PHE A 370
PHE A  90
ALA A  91
ILE A  77
ALA A  78
 None
 1.09A 5vc0A-2dkhA:
undetectable		 5vc0A-2dkhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FU4_A_HSMA401_1
(PROBABLE CHEMOTAXIS
TRANSDUCER)		 2dkh 3-HYDROXYBENZOATE
HYDROXYLASE
(Comamonas
testosteroni) 		5 / 9 TYR A 327
TYR A 392
GLU A 395
TYR A 449
ASP A 368
 None
 1.39A 6fu4A-2dkhA:
1.7		 6fu4A-2dkhA:
8.24