SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dkk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		3 / 3 LEU A  47
PRO A  48
LEU A  85
 None
 0.38A 1hrkA-2dkkA:
undetectable		 1hrkA-2dkkA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		4 / 8 CYH A 356
HIS A 104
LEU A  96
LEU A 238
 HEM  A 430 (-2.4A)
HEM  A 430 (-3.9A)
HEM  A 430 (-4.0A)
None
 0.82A 1hwiB-2dkkA:
undetectable		 1hwiB-2dkkA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		4 / 8 CYH A 356
HIS A 104
LEU A  96
LEU A 238
 HEM  A 430 (-2.4A)
HEM  A 430 (-3.9A)
HEM  A 430 (-4.0A)
None
 0.81A 1hwiD-2dkkA:
undetectable		 1hwiD-2dkkA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		5 / 12 ALA A 224
GLY A 226
GLU A 234
LEU A 107
ALA A 110
 None
 1.12A 1mjqC-2dkkA:
undetectable
1mjqD-2dkkA:
undetectable		 1mjqC-2dkkA:
11.97
1mjqD-2dkkA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		5 / 12 ALA A 224
GLY A 226
GLU A 234
LEU A 107
ALA A 110
 None
 1.13A 1mjqI-2dkkA:
undetectable
1mjqJ-2dkkA:
undetectable		 1mjqI-2dkkA:
11.97
1mjqJ-2dkkA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		5 / 12 LEU A 369
LEU A 368
GLN A 128
LEU A 147
LEU A 377
 None
 0.95A 1sqnB-2dkkA:
undetectable		 1sqnB-2dkkA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		3 / 3 ASP A 327
ILE A  66
VAL A 294
 None
 0.64A 2avvD-2dkkA:
undetectable		 2avvD-2dkkA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		5 / 5 LEU A 403
VAL A 160
LEU A 361
MET A 256
ARG A 126
 None
None
HEM  A 430 (-4.7A)
None
None
 1.46A 2oiqA-2dkkA:
undetectable		 2oiqA-2dkkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		4 / 4 LEU A 134
ALA A 158
VAL A 159
PRO A 156
 None
 1.23A 3gv1B-2dkkA:
undetectable		 3gv1B-2dkkA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		3 / 3 LEU A  47
PRO A  48
LEU A  85
 None
 0.46A 3w1wB-2dkkA:
undetectable		 3w1wB-2dkkA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		4 / 6 ARG A 363
ASP A 340
GLU A 265
LEU A 281
 None
 1.23A 4ax8A-2dkkA:
undetectable		 4ax8A-2dkkA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		6 / 12 LEU A 266
LEU A 260
LEU A 257
ARG A 263
ILE A 337
TRP A 391
 None
 1.29A 4f4dB-2dkkA:
undetectable		 4f4dB-2dkkA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		5 / 10 LEU A 266
LEU A 260
LEU A 257
ILE A 337
TRP A 391
 None
 1.25A 4mk4A-2dkkA:
undetectable		 4mk4A-2dkkA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		5 / 10 LEU A 377
LEU A 373
LEU A 369
ARG A 376
THR A 250
 None
 1.29A 4mk4A-2dkkA:
undetectable		 4mk4A-2dkkA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		3 / 3 TYR A 258
GLY A  26
PRO A  27
 None
 0.48A 4qwpA-2dkkA:
undetectable		 4qwpA-2dkkA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		4 / 6 PHE A 355
GLY A 358
TYR A 349
ALA A 362
 None
HEM  A 430 ( 3.7A)
HEM  A 430 (-4.6A)
HEM  A 430 ( 3.7A)
 1.14A 4yshB-2dkkA:
undetectable		 4yshB-2dkkA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		3 / 3 ASP A 327
VAL A  63
LEU A 347
 None
 0.54A 5e5jB-2dkkA:
undetectable		 5e5jB-2dkkA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		4 / 4 GLN A 365
THR A 366
LEU A 147
LEU A 152
 None
 1.14A 5m5kB-2dkkA:
undetectable		 5m5kB-2dkkA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		3 / 3 MET A  37
ASP A 335
ARG A 398
 None
 1.16A 5z6jA-2dkkA:
undetectable		 5z6jA-2dkkA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		5 / 10 VAL A 163
ALA A 119
PHE A 115
VAL A 217
THR A 120
 None
None
HEM  A 430 (-4.4A)
None
None
 1.14A 6aogA-2dkkA:
undetectable		 6aogA-2dkkA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		5 / 10 VAL A 163
ALA A 119
PHE A 115
VAL A 217
THR A 120
 None
None
HEM  A 430 (-4.4A)
None
None
 1.14A 6aogB-2dkkA:
undetectable		 6aogB-2dkkA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		3 / 3 TYR A  60
ASN A 351
LEU A 347
 None
 0.84A 6b58A-2dkkA:
undetectable		 6b58A-2dkkA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		5 / 9 ALA A 210
ALA A 224
GLY A 226
ALA A 235
GLY A 231
 None
 1.12A 6bklE-2dkkA:
undetectable
6bklF-2dkkA:
undetectable
6bklG-2dkkA:
undetectable
6bklH-2dkkA:
undetectable		 6bklE-2dkkA:
5.46
6bklF-2dkkA:
5.46
6bklG-2dkkA:
5.46
6bklH-2dkkA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 2dkk CYTOCHROME P450
(Streptomyces
coelicolor) 		5 / 12 PHE A 155
VAL A 360
ARG A 291
ILE A 181
ALA A 248
 None
None
HEM  A 430 ( 4.4A)
None
HEM  A 430 ( 3.5A)
 0.96A 6c2mA-2dkkA:
undetectable		 6c2mA-2dkkA:
12.90